Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver

Mitsui, Ikki; Ohtsuki, Shigeaki; Uchida, Kazuyuki

doi:10.3390/ani11113324

Cited by 6 publications

(6 citation statements)

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“…This has also been a reported gallbladder neoplasm in humans 27 . Although gallbladder adenomas were reported in a separate study, 28 this is only the second published case containing an ultrasonographic description in the veterinary literature 17 …”

Section: Discussionmentioning

confidence: 72%

“…26 This has also been a reported gallbladder neoplasm in humans. 27 Although gallbladder adenomas were reported in a separate study, 28 this is only the second published case containing an ultrasonographic description in the veterinary literature. 17 This is the first published report of gastrointestinal stromal tumor (GIST) metastasis to the gallbladder in dogs.…”

Section: Discussionmentioning

confidence: 83%

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Ultrasonographic Appearance of Gallbladder Neoplasia in 14 Dogs and 1 Cat

MacLeod¹,

Reichle²,

Szabo³

et al. 2023

Vet Radiology Ultrasound

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Ultrasonography is the most commonly used diagnostic imaging tool for gallbladder disease in veterinary medicine. Primary gallbladder neoplasia is an uncommon finding with variable prognosis for which no studies have been published describing their ultrasonographic appearance and diagnosis. This retrospective, multicenter, case series study examines the ultrasonographic appearance of gallbladder neoplasia with histologically or cytologically confirmed diagnoses. A total of 14 dogs and 1 cat were analyzed. All discrete masses were sessile in shape and varied in size, echogenicity, location, and gallbladder wall thickening. All studies with images showing Doppler interrogation exhibited vascularity. Cholecystoliths were an uncommon finding, being present in only one case in this study, unlike in humans. The final diagnosis of the gallbladder neoplasia was neuroendocrine carcinoma (8), leiomyoma (3), lymphoma (1), gastrointestinal stromal tumor (1), extrahepatic cholangiocellular carcinoma (1), and adenoma (1). Findings from this study indicate that primary gallbladder neoplasms have variable sonographic appearances and cytologic and histologic diagnoses.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 83%

Ultrasonographic Appearance of Gallbladder Neoplasia in 14 Dogs and 1 Cat

MacLeod¹,

Reichle²,

Szabo³

et al. 2023

Vet Radiology Ultrasound

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“…The criteria for examination are listed in Supplementary Table S1. Gallbladder mucosal inflammation was graded histologically based on the published criteria [11]: severe, mild, or no inflammation. Mucocele was characterized histologically by abundant, amorphous, amphophilic, thick gelatinous material expanding the gallbladder lumen and adhered to the hyperplastic mucosa.…”

Section: Histopathologymentioning

confidence: 99%

“…Gallbladder wall total thickness (GWTT) was measured on the whole-slide images, prepared by a virtual slide scanner (NanoZoomer S210, Hamamatsu Photonics K.K., Shizuoka, Japan). GWTT measurement was defined as the distance between mucosal and serosal surfaces, avoiding extreme thickness or thinness in each specimen [11].…”

Section: Histopathologymentioning

confidence: 99%

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Canine Gallbladder Erosion/Ulcer and Hemocholecyst: Clinicopathological Characteristics of 14 Cases

Mitsui,

Uchida

2023

Animals

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(1) Background: Gallbladder mucosal erosion and/or ulceration are illnesses associated with unexpected gallbladder intra-cystic bleeding (hemocholecyst), an under-reported problem in dogs. (2) Methods: Clinicopathological characteristics of 14 dogs with gallbladder erosion/ulcer were investigated in this single-center retrospective study using clinical data and archived gallbladder tissues of client-owned dogs. (3) Results: Canine gallbladder erosion/ulcer tends to occur in older, neutered dogs of various breeds. Vomiting, lethargy, and anorexia are common. Concurrent gallbladder rupture occurred in 5/14 cases (35.7%), while rupture was absent in 6/14 cases (42.8%) and undetermined in 3/14 (21.4%) cases. Histologically, the gallbladder wall was markedly thickened due to mucosal hyperplasia, inflammatory infiltrates, fibrosis, edema, hemorrhage, and smooth muscle hyperplasia/hypertrophy. Twelve out of fourteen cases (85.7%) had concurrent cholecystitis of varying severity. Bacteria were detected by Giemsa or Warthin–Starry stain in 8/14 (57.1%) cases. Bacterial rods immunoreactive to the anti-Helicobacter antibody were present in one case. Mucosal epithelial cells of the gallbladder erosion/ulcer cohort were immunopositive for the cyclooxygenases COX-1 or COX-2 in only 5/14 (35.7%) cases. In contrast, COX-1 and COX-2 were more frequently expressed in a reference pool of cases of gallbladder mucocele (n = 5) and chronic cholecystitis (n = 5). COX-1 was expressed in 9/10 cases (90.0%) of gallbladder mucocele and chronic cholecystitis and in 10/10 cases (100%) for COX-2. (4) Conclusions: Canine gallbladder erosion/ulcer is an under-reported condition which requires active clinical intervention. Based on the clinicopathological information reported in this study in addition to the COX-1 and COX-2 IHC results, we suggest that canine gallbladder erosion/ulcer may be related to decreased cytoprotection physiologically provided by arachidonic acid, but which is decreased or absent due to reduced COX expression because of yet undetermined etiologies.

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Ultrasound description of the coelomic cavity of the axolotl (Ambystoma mexicanum) in a clinically healthy population: a pilot study

Vieu,

Le Poul,

Tur

et al. 2024

Sci Rep

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Axolotls (Ambystoma mexicanum) are extensively studied for their relevance in human medical research. Despite being critically endangered in the wild, they have gained popularity as household pets. Although they have been kept in captivity for over a century, detailed descriptions of their coelomic organ anatomy remain limited. Also, this species exhibits significant variations compared to other amphibians. Ultrasound is a non-invasive and painless medical imaging technique, ideally suited for investigating internal organs or structures. This study focused on describing the ultrasound appearance of the axolotl coelomic cavity. It details the identification, localization and parenchymal description of major organs in 28 neotenic axolotls using ultrasound frequencies ranging from 7 to 15 MHz. The accuracy of the results was validated by comparing ultrasound findings with necropsy results from one male and one female axolotl. The heart, lung surface, liver and reproductive tracts were visualized. Measurements, along with confidence intervals, were calculated for the spleen, kidneys, testicles, gastric wall, gallbladder, and pylorus. Occasional detection of hyperechoic millimetric particles in the gallbladder or ascites was noted. However, visualization of the pancreas and bladder was not possible. This research outcomes involve the development of a comprehensive atlas comprising images obtained throughout the study. Additionally, the experiment established a reproducible and readily accessible protocol for conducting anatomy-morphological assessments in axolotl medicine. This protocol stands as a crucial preliminary stage before advancing to lesion identification.

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Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver

Cited by 6 publications

References 50 publications

Ultrasonographic Appearance of Gallbladder Neoplasia in 14 Dogs and 1 Cat

Ultrasonographic Appearance of Gallbladder Neoplasia in 14 Dogs and 1 Cat

Canine Gallbladder Erosion/Ulcer and Hemocholecyst: Clinicopathological Characteristics of 14 Cases

Ultrasound description of the coelomic cavity of the axolotl (Ambystoma mexicanum) in a clinically healthy population: a pilot study

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