Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington’s disease

Brain cholesterol therapy for Huntington's disease – Does it make sense?

“… 2 A meta‐analysis of all the cognitive data from studies on HD mice exposed to cholesterol‐increasing strategies in the brain also showed that, regardless of the approach type, delivery system, mouse genotype and time of administration, the cognitive performance of treated HD mice greatly improved relative to untreated HD groups. 2 , 3 As such, the concept of increasing cholesterol levels or stimulating its biosynthesis in the HD brain is well justified.…”

“…Intraperitoneal injection of cholesterol‐loaded nanoparticles, modified to cross the BBB, was found to be successful in two HD mouse models, providing long‐lasting behavioural and neuropathological benefits with no side effects. 3 Indeed, even giving it ahead of overt clinical features slowed disease onset. More recently, an intranasal delivery approach has shown great potential in mouse models of HD.…”