Chronic Cigarette Smoking Alters Circulating Sex Hormones and Neuroactive Steroids in Premenopausal Women

Dušková, Michaela; Šimůnková, Kateřina; Hill, Martin; Velíková, Marta; Kubátová, Jana; Kancheva, Lyudmila; Kazihnitková, Hana; Hruskovicova, Hana; Pospíšilová, Hana; Rácz, B.; Salátová, M; Cirmanová, Veronika; Králíková, Eva; Stárka, L; Pařı́zek, Antonı́n

doi:10.33549/physiolres.932164

Cited by 35 publications

(16 citation statements)

References 44 publications

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“…This effect is closely related to the effect of CS on sex hormones and seems to vary by menopausal status. Smokers have higher progesterone (Duskova et al, ), higher testosterone (Cupisti et al, ; Duskova et al, ), and lower estrogen levels (Duskova et al, ; Gu et al, ). The mediating effect of smoking on sex hormones and the subsequent risk of chronic disease, including both cancer and cardiovascular health problems, have attracted growing interest from researchers in recent decades (Benson, Green, Pirie, & Beral, ).…”

Section: Discussionmentioning

confidence: 99%

Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population

Almutairi

Alhadeq

Almeer

et al. 2019

Molec Gen & Gen Med

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Background Thymine‐DNA glycosylase (TDG) is an essential DNA‐repair enzyme which works in both epigenetic regulation and genome maintenance. It is also responsible for efficient correction of multiple endogenous DNA lesions which occur commonly in mammalian genomes. Research of genetic variants such as SNPs, resulting in disease, is predicted to yield clinical advancements through the identification of sensitive genetic markers and the development of disease prevention and therapy. To that end, the main objective of the present study is to identify the possible interactions between cigarette smoking and the rs4135050 variant of the TDG gene, situated in the intron position, among Saudi individuals. Methods TDG rs4135050 (A/T) was investigated by genotyping 239, and 235 blood specimens were obtained from nonsmokers and smokers of cigarette respectively. Results T allele frequency was found which showed a significant protective effect on Saudi male smokers (OR = 0.64, p = 0.0187) compared to nonsmoking subjects, but not in female smokers. Furthermore, smokers aged less than 29 years, the AT and AT+TT genotypes decreased more than four times the risk of initiation of smoking related‐diseases compare to the ancestral AA homozygous genotype. Paradoxically, the AT (OR = 3.88, p = 0.0169) and AT+TT (OR = 2.86, p = 0.0420) genotypes were present at a higher frequency in smoking patients aged more than 29 years as compared to nonsmokers at the same ages. Conclusion Depending on the gender and age of patients, TDG rs4135050 may provide a novel biomarker for the early diagnosis and prevention of several diseases caused by cigarette smoking.

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Section: Discussionmentioning

confidence: 99%

Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population

Almutairi

Alhadeq

Almeer

et al. 2019

Molec Gen & Gen Med

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“…In physiological pregnancies, there are differences in the levels of steroid hormones in the pregnant woman depending on the sex of the fetus, and there are differences in the steroids of newborns depending on its sex, though the data from the literature are not consistent (Kuijper et al 2013). At the same time, changes in the production of steroid hormones induced by smoking are different for women and men (Dušková et al 2012, Jandíková et al 2015, Jandíková et al 2017, and this has been demonstrated in experimental models of prenatal nicotine exposure (Cross et al 2016). This highlights the necessity for analyzing changes in smoking women during pregnancy separately depending on the sex of her child.…”

Section: Introductionmentioning

confidence: 99%

Changes to Fetal Steroidogenesis Caused by Maternal Smoking

Adamcová

Kolátorová²,

Chlupáčová³

et al. 2017

Physiol Res

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Smoking during pregnancy presents health risks for both the mother and her child. In this study we followed changes in the production of steroid hormones in pregnant smokers. We focused on changes in steroidogenesis in the blood of mothers in their 37th week of pregnancy and in mixed cord blood from their newborns. The study included 88 healthy women with physiological pregnancies (17 active smokers and 71 non-smokers). We separately analyzed hormonal changes associated with smoking according to the sex of newborns. In women with male fetuses, we found higher levels of serum cortisone, dehydroepiandrosterone (DHEA), 7α-OH-DHEA, 17-OH pregnenolone, testosterone, and androstenedione in smokers at the 37th week compared to non-smokers. In women with female fetuses, we found lower serum levels of 7β-OH-DHEA and higher androstenedione in smokers at the 37th week. We found significantly higher levels of testosterone in newborn males of smokers and higher levels of 7α-OH-DHEA in female newborns of smokers. Smoking during pregnancy induces changes in the production of steroids in both the mother and her child. These changes are different for different fetal sexes, with more pronounced changes in mothers carrying male newborns as well as in the newborn males themselves.

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“…These changes are largely due to the potent sympathomimetic effects of nicotine [ 2 ]. Smoking is known to alter hormone levels in both sexes [ 3 , 4 ]. An increase in adrenocorticotropic hormone (ACTH), cortisol, aldosterone, angiotensin converting enzyme and catecholamine levels have been described [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

No difference in hypertension prevalence in smokers, former smokers and non-smokers after adjusting for body mass index and age: a cross-sectional study from the Czech Republic, 2010

Pánková¹,

Králíková²,

Fraser³

et al. 2015

Tob. Induced Dis.

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BackgroundSeveral hypotheses suggest a temporary increase in blood pressure following smoking cessation. This may be the result of endocrine changes (e.g. alteration in adrenocorticotropic hormone and cortisol levels in post-cessation period) and/or post-cessation weight gain. Our aim was to identify factors that may be associated with the diagnosis of hypertension after quitting smoking.MethodsIn 2010, we conducted a cross-sectional survey in a sample of 2065 Czech adults, chosen by quota selection and representative according to age, gender, education, region of residence and the size of settlement, aged 18 to 94 years. We examined the association between age, gender, body mass index, smoking status, and education with the hypertension diagnosis in their personal history. Data were compiled and weighed by age categories. Statistical significance was measured by Pearson Chi-square test at the level of significance 95 %.ResultsDiagnosis of hypertension was reported in 461 (22 %) subjects, with no difference by gender. Based on univariate analysis, former smokers were more likely than non-smokers to be diagnosed for hypertension (OR 1.450 (1.110-1.900), p = 0.006). However, after adjusting for body mass index and age, the occurrence of hypertension diagnosis did not differ among non-smokers, smokers and former smokers (OR 0.760 for smokers, p = 0.082 and OR 1.020 for former smokers, p = 0.915).ConclusionWe did not find any differences in hypertension diagnosis prevalence according to smoking status.

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Chronic Cigarette Smoking Alters Circulating Sex Hormones and Neuroactive Steroids in Premenopausal Women

Cited by 35 publications

References 44 publications

Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population

Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population

Changes to Fetal Steroidogenesis Caused by Maternal Smoking

No difference in hypertension prevalence in smokers, former smokers and non-smokers after adjusting for body mass index and age: a cross-sectional study from the Czech Republic, 2010

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