Rossi et al. (1) show that patients suffering from cluster headache (CH) have a greater prevalence of both lifetime sustained intensive use of illicit drugs and of current intensive use of cannabis as compared to healthy controls. At first glance, these findings seem in line with the well-documented abuse of nicotine (80% smokers as compared to 35% in the general population) (2), relatively high coffee consumption and the finding that 26% of cluster patients regularly use cannabis (3). There are conflicting data regarding alcohol consumption, with clinicians and smaller studies reporting significant abuse and a recent study by Schu¨rks et al., who report the opposite (4).There are two immediate concerns that come to mind when discussing these results. One is the interpretation of the concrete findings and the other concerns the consequences of these data when considering the recent hype promoting the use of illicit drugs in CH.Regarding the first issue, it is intriguing that Rossi et al. (1) found that significant misuse of illicit drugs only holds true for male, but not for female cluster patients. One could argue that the sample size of 210 patients (48 females) is too small for proper statistics, but it is more likely that it is indeed the male cluster patients who are more prone to addictive behaviour. Or is it? Regarding another (albeit legal) drug, nicotine, no difference between male and female patients was found.