Chronic coadministration of carbamazepine together with imipramine produces antidepressant-like effects in an ACTH-induced animal model of treatment–resistant depression: Involvement of 5-HT2A receptors?

Abstract

The use of carbamazepine has been reported to be an effective treatment for severe depression. We have already shown that the antidepressant-like effects of tricyclic antidepressants in the rat forced swim test (FST) are blocked by chronic treatment with adrenocorticotropic hormone (ACTH). In the present study, we examined the effect of the chronic administration of carbamazepine on the FST and the wet-dog shakes induced by

Antipsychotic, antidepressant, and cognitive-impairment properties of antipsychotics: rat profile and implications for behavioral and psychological symptoms of dementia

“…Imipramine’s effect is therefore only about 2-fold greater than that elicited by antipsychotic drugs, suggesting that the latter’s effects on mood modulation may be pharmacologically relevant. Nevertheless, higher doses of imipramine are sometimes reported to elicit larger responses so the antidepressant-like effects observed with the antipsychotics should be interpreted with caution (Kitamura et al 2008). However, it would be interesting to evaluate the activity of clozapine and other antipsychotics in the FST upon chronic treatment—their efficacy may increase with repeated administration, as is the case for reuptake inhibitors, including imipramine (Koek et al 1998).…”

Asenapine modulates mood‐related behaviors and 5‐HT1A/7 receptors‐mediated neurotransmission

“…The results of the present study show that Asenapine behaved as a potent antimanic‐like agent in the 72 h‐SD model of mania . Moreover, neither Asenapine nor the TCA imipramine presented antidepressant properties in the ACTH model of antidepressant‐resistance . At last, the electrophysiological results showed, for the first time in vivo, that Asenapine acted as a potent 5‐HT 7 receptor antagonist, a receptor known to control DRN 5‐HT neuronal firing activity …”

“…In the FST, Kitamura et al . were the first to report that chronically administered ACTH (100 μg/d, s.c.), leading to sustained increase in plasmatic corticosterone, counteracts the decrease in the immobility time caused by classical antidepressants including the TCA imipramine, desipramine and the dual serotonin and noradrenaline reuptake inhibitor milnacipran . Remarkably, similar results are obtained after repeated electroconvulsive seizures and treatment with the dual norepinephrine and dopamine reuptake inhibitor buproprion .…”

“…Actually, several groups have proposed that chronic treatment with ACTH can be a useful animal model of TCA treatment‐resistant depression . More recently, the antidepressant‐like effects of ketamine and nucleus accumbens deep‐brain stimulation have been successfully evaluated in this rodent model of TCA resistance .…”

“…Kitamura et al . proposed that animals chronically treated with ACTH can be a useful animal model of TCA treatment‐resistant depression . Another relevant model of mania is the rapid eye movement (REM) sleep deprivation (SD) model, firstly proposed by Gessa et al., that produces a transient episode of hyperactivity and insomnia, major clinical symptoms of manic episodes.…”