2001
DOI: 10.1080/003655101753267964
|View full text |Cite
|
Sign up to set email alerts
|

Chronic cobalt exposure affects antioxidants and ATP production in rat myocardium

Abstract: Chronic cobalt exposure is characterized by severe cardiac insufficiency. Since the mechanisms of cobalt toxicity are not yet clear, we analysed the effects of chronic cobalt exposure on antioxidant enzyme activities and myocardial mitochondrial ATP production rate in a rat model. One group of rats was fed a conventional diet and another a cobalt supplemented diet for 24 weeks. The manganese-superoxide dismutase activity was markedly reduced in the cobalt rats (18+/-4.7 U/mg protein) compared to the control ra… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
15
1

Year Published

2004
2004
2021
2021

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 33 publications
(17 citation statements)
references
References 26 publications
1
15
1
Order By: Relevance
“…For example, the canine model of cobalt-induced cardiomyopathy required a daily intravenous dose of 5 mg/kg cobalt sulfate in conjunction with a low-protein, lowthiamine diet (30). Chronic cobalt exposure (6 mo) resulted in a marked decrease in the activity of manganese superoxide dismutase (a major antioxidant enzyme) as well as in mitochondrial ATP production in rat myocardium (9). Cobaltinduced heart failure occurred only with a 110 mg/kg cumulative dose of cobalt sulfate (i.e., the daily intravenous injection continued for Ͼ3 wk).…”
Section: Discussionmentioning
confidence: 99%
“…For example, the canine model of cobalt-induced cardiomyopathy required a daily intravenous dose of 5 mg/kg cobalt sulfate in conjunction with a low-protein, lowthiamine diet (30). Chronic cobalt exposure (6 mo) resulted in a marked decrease in the activity of manganese superoxide dismutase (a major antioxidant enzyme) as well as in mitochondrial ATP production in rat myocardium (9). Cobaltinduced heart failure occurred only with a 110 mg/kg cumulative dose of cobalt sulfate (i.e., the daily intravenous injection continued for Ͼ3 wk).…”
Section: Discussionmentioning
confidence: 99%
“…Further the glucose levels, although significantly reduced, were still in the hyperglycemic range. Cobalt has been reported to have toxic effects when given in higher concentrations (Clyne et al 2001), thus making its effects controversial. In this study, we report the effects of cobalt on the markers of diabetes in rats injected with streptozotocin (STZ), a pancreatic bcell toxin.…”
Section: Introductionmentioning
confidence: 99%
“…The aim and objective of our present study was to assess the concentrations of As, Cd, Co, Ni, and Pb in the biological samples (blood and urine) of myocardial infarction (MI) patients at different stages (first, second, and third attacks) of both genders and correlated with control subjects of matched age group (45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60) years. The variation in levels of understudy TEs was evaluated with related to severity of MI at different stages.…”
mentioning
confidence: 99%