Chronic consumption of a low calorie, high polyphenol cranberry beverage attenuates inflammation and improves glucoregulation and HDL cholesterol in healthy overweight humans: a randomized controlled trial

Abstract

Purpose We studied the health benefits of low calorie cranberry beverage consumption on glucoregulation, oxidative damage, inflammation, and lipid metabolism in overweight but otherwise healthy humans. Methods 78 overweight or obese men and women (30-70 years; BMI 27-35 kg/m 2 ) with abdominal adiposity (waist: hip > 0.8 for women and > 0.9 for men; waist: height ≥ 0.5) consumed 450 mL placebo or low calorie, high polyphenol cranberry extract beverage (CEB) daily for 8 week in a randomized, double-blind, placebo-controlled, parallel design trial. Blood and urine samples were collected after overnight fast at baseline and after 8 weeks of daily beverage consumption. Blood and urine samples were also collected during 3 oral glucose tolerance test (OGTT) challenges: (1) pre-intervention without the test beverages, (2) following a single dose of placebo or CEB at baseline (week 0), and (3) following a single dose of placebo or CEB at 8 week. Results Compared to placebo, a single CEB dose at baseline lowered endothelin-1 and elevated nitric oxide and the reduced:oxidized glutathione ratio (P < 0.05). Interferon-γ was elevated (P < 0.05) after a single CEB dose at baseline; however, after 8 week of CEB intervention, fasting C-reactive protein was lower (P < 0.05). CEB consumption for 8 week also reduced serum insulin and increased HDL cholesterol compared to placebo (P < 0.05). Conclusions An acute dose of low calorie, high polyphenol cranberry beverage improved antioxidant status, while 8 week daily consumption reduced cardiovascular disease risk factors by improving glucoregulation, downregulating inflammatory biomarkers, and increasing HDL cholesterol.

Effect of daily consumption of cranberry beverage on insulin sensitivity and modification of cardiovascular risk factors in adults with obesity: a pilot, randomised, placebo-controlled study

“…This was in line with null findings of another study by Lee et al (11) . However, null findings from these two studies were in contrast to other cranberry studies (6,7,9) . In a study conducted by Shidfar et al (9) , drinking one cup of cranberry juice daily for 12 weeks lowered fasting glucose by approximately 1•1 mmol/l (20 mg/dl) among fifty-eight men with type 2 diabetes.…”

“…Cranberries are rich in polyphenols and thus have a high antioxidant capacity, potentially providing health benefits to humans (2) . Studies with cranberry consumption over 2-12 weeks in healthy adults have demonstrated improvement in lipids, blood pressure and biomarkers of oxidative stress (3)(4)(5)(6)(7)(8) .…”

Nutrition Improvement of Elementary Students with Intervention of Tilapia Fish Flour and Sardine Fish Flour Based Biscuits

“…According to Hartog et al Culture of eating is an important factor in the process to receive new product. The new product will be more easily accepted if the product is considered to be in accordance with a strong concept of what can be eaten and technically applicable in the region [17] [18]. Similar thing is also reported by [19][20] [21], the higher a person's compliance to take part in a research program, the higher the increase for the final outcome of the intervention, and vice versa.…”

Oligosaccharides and Complex Carbohydrates: A New Paradigm for Cranberry Bioactivity

“…For example, one result of this type of bias is that cranberry complex carbohydrates are likely to be unrecognized but significant contributors to the immune-related and cardiometabolic health benefits associated with cranberry materials [3,7,14,17,309]. The fermentation of cranberry complex carbohydrates may lead to beneficial microbiota profiles and SCFA production [74,131,132] that, together, promote epithelial cell health and cholesterol lowering effects as has been observed for other dietary fibers [165,187,189,303].…”

“…Decreases in bile acid levels have been associated with the cholesterol-lowering effects of certain foods, such as oats, and with the detoxification of harmful and carcinogenic metabolites [126,187,189,304]. Investigations of other dietary fibers have indicated that fiber viscosity may influence bile acid binding and subsequent cholesterol lowering effects [189] and the high viscosity of soluble cranberry pectins [139] may therefore contribute to the bile acid binding and cholesterol lowering effects observed for cranberry materials [7,154,309].…”