Chronic Deafness Degrades Temporal Acuity in the Electrically Stimulated Auditory Pathway

Middlebrooks, John C.

doi:10.1007/s10162-018-0679-3

Cited by 11 publications

(10 citation statements)

References 52 publications

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“…The auditory system beyond the cochlea (auditory nerve and central nervous system) may have undergone significant pathological changes due to deafness in the CI listeners (e.g., Middlebrooks, 2018; Shepherd & Hardie, 2001). For example, previous studies suggest that hearing impairment results in the loss of auditory fibers (e.g., Middlebrooks, 2018; Webster & Webster, 1981), which may lead to decreased neural synchrony to auditory stimuli. Decreased neural synchrony may be one of the mechanisms underlying the reduced ability to process temporal cues with increasing levels in CI listeners.…”

Section: Discussionmentioning

confidence: 99%

Age-Related Temporal Processing Deficits in Word Segments in Adult Cochlear-Implant Users

et al. 2019

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Aging may limit speech understanding outcomes in cochlear-implant (CI) users. Here, we examined age-related declines in auditory temporal processing as a potential mechanism that underlies speech understanding deficits associated with aging in CI users. Auditory temporal processing was assessed with a categorization task for the words dish and ditch (i.e., identify each token as the word dish or ditch) on a continuum of speech tokens with varying silence duration (0 to 60 ms) prior to the final fricative. In Experiments 1 and 2, younger CI (YCI), middle-aged CI (MCI), and older CI (OCI) users participated in the categorization task across a range of presentation levels (25 to 85 dB). Relative to YCI, OCI required longer silence durations to identify ditch and exhibited reduced ability to distinguish the words dish and ditch (shallower slopes in the categorization function). Critically, we observed age-related performance differences only at higher presentation levels. This contrasted with findings from normal-hearing listeners in Experiment 3 that demonstrated age-related performance differences independent of presentation level. In summary, aging in CI users appears to degrade the ability to utilize brief temporal cues in word identification, particularly at high levels. Age-specific CI programming may potentially improve clinical outcomes for speech understanding performance by older CI listeners.

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Section: Discussionmentioning

confidence: 99%

Age-Related Temporal Processing Deficits in Word Segments in Adult Cochlear-Implant Users

et al. 2019

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“…Assuming that the cochlear apex receives less direct stimulation than sites located close to the stimulating electrodes, consequences similar to those associated with the effect of auditory deprivation may occur, which has been shown to lead to reduced phase-locking in the IC (Vollmer et al 2005 , 2017 ). Further, reduced temporal responses in the IC seen in long-term deafened animals have been shown to be most severe at IC depths that correspond to low characteristic frequencies (Middlebrooks 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that a high-temporal-acuity brainstem pathway can be triggered when stimulation originates from apical, rather than basal, cochlear sites (Middlebrooks and Snyder 2010 ; Middlebrooks 2018 ). This study investigated the effect of stimulating more apically compared to standard methods of CI stimulation, using both the phantom-electrode mode of stimulation and pseudomonophasic anodic-first (PSA) pulse trains.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Phantom Stimulation and Pseudomonophasic Pulse Shapes on Pitch Perception by Cochlear Implant Listeners

Lamping

Deeks

Marozeau

et al. 2020

JARO

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It has been suggested that a specialized high-temporal-acuity brainstem pathway can be activated by stimulating more apically in the cochlea than is achieved by cochlear implants (CIs) when programmed with contemporary clinical settings. We performed multiple experiments to test the effect on pitch perception of phantom stimulation and asymmetric current pulses, both supposedly stimulating beyond the most apical electrode of a CI. The two stimulus types were generated using a bipolar electrode pair, composed of the most apical electrode of the array and a neighboring, more basal electrode. Experiment 1 used a pitch-ranking procedure where neural excitation was shifted apically or basally using so-called phantom stimulation. No benefit of apical phantom stimulation was found on the highest rate up to which pitch ranks increased (upper limit), nor on the slopes of the pitch-ranking function above 300 pulses per second (pps). Experiment 2 used the same procedure to study the effects of apical pseudomonophasic pulses, where the locus of excitation was manipulated by changing stimulus polarity. A benefit of apical stimulation was obtained for the slopes above 300 pps. Experiment 3 used an adaptive rate discrimination procedure and found a small but significant benefit of both types of apical stimulation. Overall, the results show some benefit for apical stimulation on temporal pitch processing at high pulse rates but reveal that the effect is smaller and more variable across listeners than suggested by previous research. The results also provide some indication that the benefit of apical stimulation may decline over time since implantation.

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“…Assuming that the cochlear apex receives less direct stimulation than sites located close to the stimulating electrodes, consequences similar to those associated with the effect of auditory deprivation may occur, which has been shown to lead to reduced phase-locking in the IC (Vollmer et al 2005(Vollmer et al , 2017. Further, reduced temporal responses in the IC seen in long-term deafened animals have been shown to be most severe at IC depths that correspond to low characteristic frequencies (Middlebrooks 2018).…”

Section: Across-subject Variability For Psa Stimulationmentioning

confidence: 99%

“…It has been suggested that a high-temporal-acuity brainstem pathway can be triggered when stimulation originates from apical, rather than basal, cochlear sites (Middlebrooks and Snyder 2010;Middlebrooks 2018). This study investigated the effect of stimulating more apically compared to standard methods of CI stimulation, using both the phantom-electrode mode of stimulation and pseudomonophasic anodic-first (PSA) pulse trains.…”

Section: Summary Of the Findingsmentioning

confidence: 99%

The effect of phantom stimulation and pseudomonophasic pulse shapes on pitch perception by cochlear implant listeners

Lamping¹,

Deeks²,

Marozeau³

et al. 2020

Preprint

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It has been suggested that a specialised high-temporal-acuity brainstem pathway can be activated by stimulating more apically in the cochlea than is achieved by cochlear implants (CIs) when programmed with contemporary clinical settings. Muliple experiments were carried out to test the effect of phantom stimulation and asymmetric current pulses, both supposedly stimulating beyond the most apical electrode of a CI, on pitch perception. The two stimulus types were generated using a bipolar electrode pair, composed of the most apical electrode of the array and a neighbouring, more basal electrode. Experiment 1 used a pitch-ranking procedure where neural excitation was shifted apically or basally using so-called phantom stimulation. No benefit of apical stimulation was found on the highest rate up to which pitch ranks increased, nor on the slopes of the pitch-ranking function above 300 pulses per second (pps). Experiment 2 used the same procedure to study the effects of asymmetric pseudomonophasic pulses, where the locus of excitation was manipulated by changing stimulus polarity. A benefit of apical stimulation was obtained only for the slopes above 300 pps. Experiment 3 used an adaptive rate discrimination procedure and a small but significant benefit of apical stimulation was found. Overall the results show some benefit for apical stimulation on temporal pitch processing at high pulse rates but reveal that the effect is rather small and highly variable across listeners. The results also provide some indication that the benefit of apical stimulation may decline over time since implantation.

show abstract

Chronic Deafness Degrades Temporal Acuity in the Electrically Stimulated Auditory Pathway

Cited by 11 publications

References 52 publications

Age-Related Temporal Processing Deficits in Word Segments in Adult Cochlear-Implant Users

Age-Related Temporal Processing Deficits in Word Segments in Adult Cochlear-Implant Users

The Effect of Phantom Stimulation and Pseudomonophasic Pulse Shapes on Pitch Perception by Cochlear Implant Listeners

The effect of phantom stimulation and pseudomonophasic pulse shapes on pitch perception by cochlear implant listeners

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