Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles

Howitt, Lauren; Kuo, Ivana Y.; Ellis, Anthie; Chaston, Daniel J.; Shin, Hee‐Sup; Hansen, Pernille; Hill, Caryl E.

doi:10.1093/cvr/cvt043

Cited by 28 publications

(38 citation statements)

References 48 publications

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“…Both Ca V 3.1 and Ca V 3.2 are present in arterioles from rat cremaster muscle 64 and pharmacological evidence suggests that T-type currents contribute significantly to myogenic tone in this vascular bed 82 at physiologic pressures (75 mmHg). Furthermore, T-type channels contributed to basal tone in cremaster muscle vessels in vivo and their contribution was increased at reduced NO levels, most likely via an increase in reactive oxygen species.…”

Section: Skeletal Muscle Circulationmentioning

confidence: 99%

“…Furthermore, T-type channels contributed to basal tone in cremaster muscle vessels in vivo and their contribution was increased at reduced NO levels, most likely via an increase in reactive oxygen species. 64 Such regulation may explain differences between studies and should be considered when comparing experiments from different species, vascular beds and experimental settings. However, a role for T-type channels in the autoregulation of blood flow in skeletal muscles seems possible at pressures within the physiologic range.…”

Section: Skeletal Muscle Circulationmentioning

confidence: 99%

“…60 Thus, the exact function of Ca V 3.1 and Ca V 3.2 channels in the resistance vasculature is currently under investigation using knockout mice. 46,50,[61][62][63][64] …”

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confidence: 99%

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T-type Ca²⁺channels and autoregulation of local blood flow

et al. 2017

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L-type voltage gated Ca2C channels are considered to be the primary source of calcium influx during the myogenic response. However, many vascular beds also express T-type voltage gated Ca 2C channels. Recent studies suggest that these channels may also play a role in autoregulation. At low pressures (40-80 mmHg) T-type channels affect myogenic responses in cerebral and mesenteric vascular beds. T-type channels also seem to be involved in skeletal muscle autoregulation. This review discusses the expression and role of T-type voltage gated Ca 2C channels in the autoregulation of several different vascular beds. Lack of specific pharmacological inhibitors has been a huge challenge in the field. Now the research has been strengthened by genetically modified models such as mice lacking expression of T-type voltage gated Ca 2C channels (Ca V 3.1 and Ca V 3.2). Hopefully, these new tools will help further elucidate the role of voltage gated T-type Ca 2C channels in autoregulation and vascular function.

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Section: Skeletal Muscle Circulationmentioning

confidence: 99%

Section: Skeletal Muscle Circulationmentioning

confidence: 99%

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T-type Ca²⁺channels and autoregulation of local blood flow

et al. 2017

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“…T-type channels have their dominant contractile effect in smaller arterioles compared with larger arteries (5,46,51), which might affect the results reported for T-type channel contributions to vascular tone in different studies. Furthermore, the contribution of T-type channels to vascular contractility is regulated by NO and reactive oxygen species produced by NADPH oxidase (46).…”

Section: Do T-type Channels Affect Vascular Function?mentioning

confidence: 99%

“…Furthermore, the contribution of T-type channels to vascular contractility is regulated by NO and reactive oxygen species produced by NADPH oxidase (46). In a recent study of Ca v 3.1 and Ca v 3.2 knockout mice, T-type channels were shown to contribute significantly more to the contraction of mesenteric arteries of wild-type mice after L-NAME treatment, an effect that was attenuated in both knockout models (46). Furthermore, T-type channels were upregulated after L-NAME treatment due to increased bioavailability of reactive oxygen species.…”

Section: Do T-type Channels Affect Vascular Function?mentioning

confidence: 99%

Functional importance of T-type voltage-gated calcium channels in the cardiovascular and renal system: news from the world of knockout mice

Hansen

2015

American Journal of Physiology-Regulatory, Integrative and Comp

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Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

Tykocki

Boerman

Jackson

2017

Comprehensive Physiology

283

347

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Vascular tone of resistance arteries and arterioles determines peripheral vascular resistance, contributing to the regulation of blood pressure and blood flow to, and within the body’s tissues and organs. Ion channels in the plasma membrane and endoplasmic reticulum of vascular smooth muscle cells (SMCs) in these blood vessels importantly contribute to the regulation of intracellular Ca2+ concentration, the primary determinant of SMC contractile activity and vascular tone. Ion channels provide the main source of activator Ca2+ that determines vascular tone, and strongly contribute to setting and regulating membrane potential, which, in turn, regulates the open-state-probability of voltage gated Ca2+ channels (VGCCs), the primary source of Ca2+ in resistance artery and arteriolar SMCs. Ion channel function is also modulated by vasoconstrictors and vasodilators, contributing to all aspects of the regulation of vascular tone. This review will focus on the physiology of VGCCs, voltage-gated K+ (KV) channels, large-conductance Ca2+-activated K+ (BKCa) channels, strong-inward-rectifier K+ (KIR) channels, ATP-sensitive K+ (KATP) channels, ryanodine receptors (RyRs), inositol 1,4,5-trisphosphate receptors (IP3Rs), and a variety of transient receptor potential (TRP) channels that contribute to pressure-induced myogenic tone in resistance arteries and arterioles, the modulation of the function of these ion channels by vasoconstrictors and vasodilators, their role in the functional regulation of tissue blood flow and their dysfunction in diseases such as hypertension, obesity, and diabetes.

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Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles

Cited by 28 publications

References 48 publications

T-type Ca²⁺channels and autoregulation of local blood flow

T-type Ca²⁺channels and autoregulation of local blood flow

Functional importance of T-type voltage-gated calcium channels in the cardiovascular and renal system: news from the world of knockout mice

Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

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Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles

Cited by 28 publications

References 48 publications

T-type Ca2+channels and autoregulation of local blood flow

T-type Ca2+channels and autoregulation of local blood flow

Functional importance of T-type voltage-gated calcium channels in the cardiovascular and renal system: news from the world of knockout mice

Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles

Contact Info

Product

Resources

About

T-type Ca²⁺channels and autoregulation of local blood flow

T-type Ca²⁺channels and autoregulation of local blood flow