Chronic effects of imipramine and lithium on 5-HT receptor subtypes in rat frontal cortex, hippocampus and choroid plexus: Quantitative receptor autoradiographic analysis.

Mizuta, Tadashi; Segawa, Tomoomi

doi:10.1254/jjp.50.315

Cited by 37 publications

(6 citation statements)

References 24 publications

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“…29 We found that 2-week imipramine administration had no effect on 5-HT 1A receptor mRNA expression in the hippocampus, consistent with Lopez et al 29 However, long-term treatment with all three agents significantly decreased 5-HT 1A receptor mRNA expression in CA1 of the hippocampus. Other studies have shown small decreases 41,42 in 5-HT 1A receptor number after long-term antidepressant administration. The mechanisms responsible for the delayed decrease in 5-HT 1A receptor mRNA expression after daily treatment with Hypericum extract, and hypericin, and imipramine are unknown.…”

Section: Experiments 1-chronic Administration Effectsmentioning

confidence: 81%

St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats

Butterweck

Winterhoff²,

Herkenham

2001

Mol Psychiatry

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Clinical studies demonstrate that the antidepressant efficacy of St John's wort (Hypericum) is comparable to that of tricyclic antidepressants such as imipramine. Onset of efficacy of these drugs occurs after several weeks of treatment. Therefore, we used in situ hybridization histochemistry to examine in rats the effects of short-term (2 weeks) and long-term (8 weeks) However, imipramine appears to be more effective in blocking stress effects on the HPA axis than the plant extract. Molecular Psychiatry (2001) 6, 547-564.

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Section: Experiments 1-chronic Administration Effectsmentioning

confidence: 81%

St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats

Butterweck

Winterhoff²,

Herkenham

2001

Mol Psychiatry

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“…We revealed recently that the down-regulation of the 5-HT~ receptors in rat hippocampus induced by lithium treatment is ascribed chiefly to the decrease in the 5-HT1A subtypes (Odagaki etal., 1990), although Mizuta and Segawa (1989) reported that the 5-HT1 c sites were also involved in the downregulation of the 5-HT1 receptors. No alterations in the inhibition of forskolinstimulated adenylate cyclase activity by 5-HT after the chronic lithium treatment were apparently aganist expectation from the binding data.…”

Section: Discussionmentioning

confidence: 99%

No alterations in the 5-HT1A-mediated inhibition of forskolin-stimulated adenylate cyclase activity in the hippocampal membranes from rats chronically treated with lithium or antidepressants

Odagaki

Koyama

Yamashita

1991

J. Neural Transmission

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In order to determine the relevance of 5-HT1A-related signal transduction in the mode of action of lithium and antidepressants, the effects of long-term treatment with these drugs on the 5-HT1A-mediated inhibition of forskolin-stimulated adenylate cyclase activity were investigated in the rat hippocampal membranes. Chronic administration of antidepressants altered neither the [3H]8-hydroxy-2-(di-n-propylamino)tetralin [( 3H]8-OH-DPAT) binding sites nor the inhibition of forskolin-stimulated adenylate cyclase activity by 5-HT. Long-term treatment with lithium did not affect the inhibitory effect of 5-HT on the forskolin-stimulated adenylate cyclase activity, either. Neither the stimulation by forskolin nor the inhibition by guanyl-5'-ylimidodiphosphate (Gpp(NH)p) of adenylate cyclase activity was not influenced by lithium treatment, suggesting that lithium has no effects on the components of adenylate cyclase system distal to the 5-HT1A receptors. These results indicate that the 5-HT1A-mediated neural transmission has not such an important relevance in the mechanisms of action of lithium or antidepressants.

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“…Previously we reported that repeated treatment with ECS increased [3H]8-hydroxy-2-(di-n-propylamino)tetraline ([3H]8-OH-DPAT) binding sites in the rat hippo campus, and it did not relate to the presynaptic serotoner gic neuron activity [4], It is still controversial now the 5-HT) a receptors are modulated, namely up-or down-regu lated in specific brain regions after antidepressant treat ment [4][5][6][7][8]. It is difficult to examine changes of binding sites in specific brain region in details by ligand binding analysis using membrane preparation.…”

Section: Introductionmentioning

confidence: 99%

Increase in Serotonin 1A Receptors in the Dentate Gyrus as Revealed by Autoradiographic Analysis Following Repeated Electroconvulsive Shock But Not Imipramine Treatment

Hayakawa

Shimizu²,

Nishida³

et al. 1994

Neuropsychobiology

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The effects of repeated treatment with electroconvulsive shock (ECS) and imipramine on [³H]8-OH-DPAT binding to serotonin_1A (5-HT_1A) receptors in the rat brain were studied by quantitative autoradiographic analysis. A large number of binding sites for [³H]8-OH-DPAT were observed in the hippocampus, especially the dentate gyrus, CA₁+CA₂ field, dorsal raphe nucleus and septum. Repeated treatment with ECS, but not repeated imipramine treatment, significantly increased [³H]8-OH-DPAT binding sites in the dentate gyrus. These results suggest that the increase in [³H]8-OH-DPAT binding sites in the dentate gyrus may be important in ECS therapy for depressive illness.

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Chronic effects of imipramine and lithium on 5-HT receptor subtypes in rat frontal cortex, hippocampus and choroid plexus: Quantitative receptor autoradiographic analysis.

Cited by 37 publications

References 24 publications

St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats

St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats

No alterations in the 5-HT1A-mediated inhibition of forskolin-stimulated adenylate cyclase activity in the hippocampal membranes from rats chronically treated with lithium or antidepressants

Increase in Serotonin 1A Receptors in the Dentate Gyrus as Revealed by Autoradiographic Analysis Following Repeated Electroconvulsive Shock But Not Imipramine Treatment

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