Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin

Smigic, Jelena; Sabo, Tibor J.; Vranic, Aleksandra; Živković, Vladimir; Srejović, Ivan; Turnic, Tamara Nikolic; Milosavljevic, Isidora; Poljarević, Jelena; Krivokapic, Milos; Bolevich, Sergey; Jakovljević, Vladimir

doi:10.1007/s11010-019-03533-8

Cited by 4 publications

(4 citation statements)

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“…Since the activated caspase-3 is one of the main executors, through the activation of DNA-ase, for both intrinsic and extrinsic apoptotic pathways [23] we decided to evaluate its activity in the present model of CP-induced lung tissue damage. The application of CP caused an increase in the activity of caspase-3 and DNA-ases which agrees with the proapoptotic activity of this chemotherapeutic agent [8]. Also, CP application has previously been found to cause capase-3 cleavage inducing apoptosis and cell damage in kidneys [24], testes [25], and sensory neurons [26].…”

Section: Discussionmentioning

confidence: 54%

“…The mechanisms associated with CP cell damage include oxidative capacities depletion, ROS formation, DNA damage, stimulation of inflammatory response in certain tissues, mitochondrial dysfunction, and induction of apoptosis [5, 7]. Previous studies showed that CP covalently binds 5–10% of DNA, while 75–85% of the drug interacts with non-DNA molecules such as glutathione [8].…”

Section: Introductionmentioning

confidence: 99%

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Lycopene and Caffeic Acid Phenethyl Ester Affect Caspase-3 Activity, but Do Not Alter the NO Pathway in Lung Tissue Damage Induced by Cisplatin

et al. 2021

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Introduction: Antioxidants such as lycopene (LCP) and caffeic acid phenethyl ester (CAPE) represent ideal molecules for the treatment of different reactive oxygen species (ROS) associated disorders. Cisplatin is a chemotherapeutic agent, causing an increase in ROS and DNA damage, with numerous side effects, which include lung toxicity. In the presents study, we evaluated and mutually compared the potential of LCP and CAPE in preventing cisplatin-induced rat lung damage. Methods: The study was done using pathohistological analysis and a panel of biochemical parameters that reflect lung oxidative tissue damage, inflammation, and apoptosis. Results: The obtained results suggest that cisplatin (10 mg/kg) causes significant disturbances in the lung tissue morphology, followed by an increase in lipid peroxidization and protein modification. Also, a pronounced inflammatory response and cell apoptosis cascade activation was noted. Both LCP and CAPE were able to mitigate the changes, to a different extent, in oxidative damage and apoptosis progression induced by cisplatin. However, they both had limited effect on inflammation since they only prevented an increase in myeloperoxidase activity but had not been able to prevent the NO generation. Conclusion: It is hard to be exact in saying whether LCP or CAPE is better in preventing cisplatin-induced lung damage since they obviously possess different mechanisms of action.

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Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Lycopene and Caffeic Acid Phenethyl Ester Affect Caspase-3 Activity, but Do Not Alter the NO Pathway in Lung Tissue Damage Induced by Cisplatin

et al. 2021

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“…Cisplatin [cis-diamminedichloroplatin (II)] (CP), is a DNA alkylating chemotherapeutic agent containing platinum and it is widely used in the treatment of various types of tumors involving head and neck, lung, bladder, testicle, cervix, and also lymphomas and childhood solid tumors [1][2][3] . It can cause serious side effects such as nephrotoxicity, ototoxicity and cardiovascular complications [2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

“…There are limitations to the use of CP due to its acute and cumulative cardiotoxic effects 2 . The most common side effects include pericarditis, myocarditis, arrhythmia, hypertension, heart failure and rarely ones include coronary ischemia, heart tamponade and endomyocardial fibrosis [1][2] . It has been reported that natural antioxidants can protect cells against oxidative damage 4 .…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective effect of all-trans retinoic acid on cisplatin induced cardiotoxicity in rats

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Yücel

et al. 2021

Cukurova Medical Journal

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ÖzPurpose: Cisplatin (CP) is an antineoplastic agent widely used in the treatment of various tumors. Retinoic acid has potent antioxidant effects. In this study, it is aimed to reveal the effects of all-trans retinoic acid (ATRA) on CP induced cardiotoxicity. Materials and Methods: In the study, wistar albino rats were used. Control group received single daily doses of 1 ml/kg saline and ATRA group received single daily doses of ATRA(7,5mg/kg/day) intraperitoneally (i.p.) for 10 days. ATRA+CP group received a single dose of CP(7mg/kg) i.p. on the fourth day of the 10 days of ATRA (7,5mg/kg/day) i.p. treatment. The rats in the CP group received only a single dose of cisplatin(7mg/kg) i.p. given on the 4th of 10 days of treatment. After treatment, the groups were compared based on cardiac histopathology findings. Results: Necrosis, cytoplasmic vacuolization, congestion, hemorrhage and edema were more common in the CP group than the control group). Necrosis and cytoplasmic vacuolization in the all-trans retinoic acid + cisplatin group was observed statistically significantly less frequently than the CP group. Conclusion:This study confirmed that cisplatin therapy had destructive effects on heart tissue, and showed that alltrans retinoic acid treatment could histopathologically prevent cisplatin-induced cardiotoxicity. Amaç: Cisplatin, pek çok farklı tümör tedavisinde kullanılan etkili bir antineoplastik ajandır. Retinoik asit güçlü antioksidan etkilere sahiptir. Bu çalışmanın amacı, all-trans retinoik asidin (ATRA) cisplatin kaynaklı kardiyotoksisite üzerine etkilerini araştırmaktır. Gereç ve Yöntem: Çalışmada wistar albino ratlar kullanıldı. Kontrol grubundaki ratlara 10 gün boyunca günlük 1 ml/kg salin intraperitoneal (i.p.) olarak verildi ve ATRA grubundaki ratlara 10 gün boyunca tek doz (7,5 mg/kg/gün) ATRA i.p. verildi. ATRA + CP grubundaki ratlara 10 gün boyunca tek doz (7,5 mg/kg/gün) ATRA i.p. ve tedavinin dördüncü gününde tek doz CP (7mg/kg) i.p. verildi. CP grubundaki ratlara ise 10 günlük tedavinin dördüncü gününde tek doz CP (7mg/kg) i.p. verildi. Tedaviden sonra gruplar kardiyak histopatoloji bulgularına göre karşılaştırıldı. Bulgular: Nekroz, sitoplazmik vakuolizasyon, konjesyon, kanama ve ödem cisplatin grubunda kontrol grubuna göre daha yaygındı. All-trans retinoik asid + cisplatin grubunda nekroz ve sitoplazmik vakuolizasyon, CP grubundan istatistiksel olarak anlamlı olarak daha az gözlendi. Sonuç: Bu çalışma cisplatin tedavisinin kalp dokusu üzerinde yıkıcı etkileri olduğunu doğruladı ve all-trans retinoik asid tedavisinin histopatolojik olarak cisplatine bağlı kardiyotoksisiteyi önleyebildiğini gösterdi.

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Exercise and pyridostigmine prevents gastric emptying delay and increase blood pressure and cisplatin-induced baroreflex sensitivity in rats

et al. 2021

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Chronic effects of platinum(IV) complex and its diamine ligand on rat heart function: comparison with cisplatin

Cited by 4 publications

References 38 publications

Lycopene and Caffeic Acid Phenethyl Ester Affect Caspase-3 Activity, but Do Not Alter the NO Pathway in Lung Tissue Damage Induced by Cisplatin

Lycopene and Caffeic Acid Phenethyl Ester Affect Caspase-3 Activity, but Do Not Alter the NO Pathway in Lung Tissue Damage Induced by Cisplatin

Cardioprotective effect of all-trans retinoic acid on cisplatin induced cardiotoxicity in rats

Exercise and pyridostigmine prevents gastric emptying delay and increase blood pressure and cisplatin-induced baroreflex sensitivity in rats

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