Chronic Encephalomyelitis With Specific Increase in Intrathecal Mumps Antibodies

Abstract

Symptoms of severe encephalomyelitis developed in a 31-year-old man in 1967. He had a high serum antibody titre to mumps virus associated with a polymorphic cell reaction and an increased protein concentration in cerebrospinal fluid (CSF). He recovered considerably within a year and was able to resume work. In 1975 his condition deteriorated again; it improved during the following few years, but a further deterioration then occurred. In March, 1981, the complement-fixing antibody titre to mumps virus was 1/32 in the serum and 1/4 in the CSF. In November, 1981, the CSF IgG index was increased and the altered serum/CSF antibody ratio persisted. The specificity of the altered antibody ratio was confirmed by the single radial haemolysis test and an immunoassay specific for mumps virus. Antibodies against the mumps virus envelope glycoprotein, M-protein, and nucleoprotein could be demonstrated by immunoprecipitation and the antibody patterns in serum and CSF were similar. Antibodies against other microorganisms were not detected in the patient's CSF, and mumps antibodies were not found in the CSF specimens of 57 control patients. This case may be an example of a new disease-chronic mumps virus infection in the central nervous system.

Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis

“…The presentation of this case, shares features with two previously published cases of MuV-related progressive encephalitis [13,28]. Moreover, like measles SSPE and measles inclusion body encephalitis (MIBE) [29], which occurs in immunocompromised children within months of measles infection or vaccination, and unlike acute MuV encephalitis, no virus was detected in the CSF.…”

Infections in the CNS During Childhood and the Risk of Subsequent Psychotic Illness: A Cohort Study of More Than One Million Swedish Subjects

“…In their Finnish cohort, 23 of 47 patients examined 1-15 years after the disease experienced difficulties in memory and learning, focal motor or sensory signs, or loss of hearing and visual acuity. Chronic mumps virus CNS infections in humans have also occasionally been described (28,29). In addition to these effects of mumps on the nervous system, we suggest that mumps Cytomegalovirus infection was also found to confer an increased risk for the future development of nonaffective psychotic illness (risk ratio=16.6, 95% CI=4.3-65.1), although only two patients were identified in the present material.…”

Altered White Cell Count, Protein Concentration and Oligoclonal IgG Bands in the Cerebrospinal Fluid of Many Patients with Acute Psychiatric Disorders

“…This analysis requires only 50 pi of unconcentrated CSF and may be carried out within a period of 24 h using technology widely applied in research laboratories. Al though the presence of oligoclonal bands is not diagnostic for any particular medical condition, they are well estab lished in multiple sclerosis, in HSV encephalitis as well as in many chronic CNS infections [27][28][29], Naturally, it is tempting to hypothesize that in some of our patients the psychiatric symptoms detected could be elicited or precip itated by viral infections or at least be associated with a parallel immunological aberration in the CNS.…”