Chronic eosinophilic pneumonia with persistent decreased diffusing capacity for carbon monoxide

Blanc, S.; Albertini, M.; Leroy, Sylvie; Giovannini‐Chami, Lisa

doi:10.1136/bcr-2012-008238

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…Recent studies have revealed that reduced lung CO diffusing capacity is a significant predictor of subclinical disease activity and recurrence in patients with CEP. 11 The lesions on pulmonary imaging of the 20 cases were bilateral, non-migratory with clear boundaries, and they were mainly distributed in the periphery or subpleura. The most common lesions were patchy shadows, followed by consolidation and ground glass shadows.…”

Section: Discussionmentioning

confidence: 93%

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Clinical characteristics of patients with chronic eosinophilic pneumonia in a Chinese tertiary‐care hospital: A 6‐year retrospective study

Wang

et al. 2021

Clinical Respiratory J

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Introduction: Chronic eosinophilic pneumonia (CEP) is a rare disease with unknown etiology. Due to lack of specificity of CEP symptoms, clinicians are not experienced in establishing its diagnosis. Objectives: To summarize the clinical data of CEP patients to improve the understanding of CEP and reduce misdiagnosis. Methods: Data of patients pathologically diagnosed with CEP in the PLA General Hospital between May 2013 and May 2019 were collected, and clinical manifestations, imaging characteristics, pathological features, and treatment were retrospectively analyzed.Results: Twenty patients, including 6 males and 14 females, were diagnosed with CEP. The average age was 47.0 AE 10.2 years. The main clinical manifestations were cough and dyspnea. The average duration of CEP was 15.5 AE 11.5 months. The average proportion of eosinophils in the peripheral blood was 18.9 AE 17.8%, and the average proportion of eosinophils in the bronchoalveolar lavage fluid was 41.5 AE 19.4%. The main imaging features were patchy shadows and consolidation shadows. The most common manifestations on bronchoscopic examination were congestion and edema of the bronchial mucosa. Two patients had granular protrusions of the endotracheal membrane. Histological examination indicated infiltration of numerous eosinophils. All patients improved after prednisone therapy. Conclusion: CEP onset is insidious, and clinical manifestations lack specificity. Typical imaging features are peripheral and subpleural distribution of lung infiltrates. Some patients have a normal proportion of eosinophils in the peripheral blood, but most have an increased number of eosinophils in the BALF, which contributes to CEP diagnosis. A biopsy is necessary when differential diagnosis is difficult. A systemic glucocorticoid is effective.

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Section: Discussionmentioning

confidence: 93%

“…After treatment, pulmonary function improved rapidly. Recent studies have revealed that reduced lung CO diffusing capacity is a significant predictor of subclinical disease activity and recurrence in patients with CEP 11 …”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of patients with chronic eosinophilic pneumonia in a Chinese tertiary‐care hospital: A 6‐year retrospective study

Wang

et al. 2021

Clinical Respiratory J

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“…After treatment, pulmonary function improved rapidly. Recent studies have revealed that reduced lung CO diffusivity is a signi cant predictor of disease subclinical activity and recurrence in CEP patients [11].…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of 20 Patients with Chronic Eosinophilic Pneumonia: A 6-year Retrospective Study

Xu¹,

Wang²,

Zhang³

et al. 2020

Preprint

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Abstract Background: Chronic eosinophilic pneumonia (CEP) is a rare disease and there are few systematic studies on the disease. We summarized the clinical and pathological data of CEP to improve the understanding of the disease, as well as to reduce misdiagnosis and mistreatment. Methods: The data of patients pathologically diagnosed as CEP in PLA General Hospital between May 2013 and May 2019 were collected, and the clinical manifestations, imaging characteristics, pathological features, treatment and prognosis were retrospectively analyzed. Results: There were 20 patients with CEP, including 6 males and 14 females. The average age at the time of diagnosis was 47.0 ± 10.2 (22-83) years, and the average course of disease was 15.5 ±11.5 (2-72) months. The main clinical manifestations were cough, dyspnea, expectoration, and shortness of breath, and often accompanied by fever, weight loss, and asthenia. 19 patients had elevated peripheral blood eosinophils, with the proportion of eosinophils ranging from 5.3-64.7%, and the absolute value of eosinophils ranging from 0.72-14.43×109/L. 18 patients had increased proportion of eosinophils in bronchoalveolar lavage fluid (BALF), ranging from 12-67%, with an average of 46%. The main imaging features were patchy shadows, consolidated shadows, and ground glass shadows. The histological examination of bronchial mucosal biopsy indicated eosinophilic infiltration in submucosal tissues and the pulmonary biopsy indicated a large number of eosinophils infiltration in alveolar cavity and septum as the main pathological changes of CEP. All of 20 patients were treated with glucocorticoid, and one of them relapsed during follow-up. Conclusions: The onset of CEP is insidious and the clinical manifestations are lack of specificity. Eosinophils increase in peripheral blood and BALF in most of CEP patients. The typical image is peripheral and subpleural distribution of lung infiltrates. The diagnosis of CEP depends on pathology, and glucocorticoid therapy is effective.

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Minocycline-Induced Eosinophilic Pneumonia in a Pediatric Patient

ChanMarilynn

KrakowskiAndrew

LeongCurtis

et al. 2018

Pediatric Allergy, Immunology, and Pulmonology

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Chronic eosinophilic pneumonia with persistent decreased diffusing capacity for carbon monoxide

Cited by 3 publications

References 15 publications

Clinical characteristics of patients with chronic eosinophilic pneumonia in a Chinese tertiary‐care hospital: A 6‐year retrospective study

Clinical characteristics of patients with chronic eosinophilic pneumonia in a Chinese tertiary‐care hospital: A 6‐year retrospective study

Clinical Characteristics of 20 Patients with Chronic Eosinophilic Pneumonia: A 6-year Retrospective Study

Minocycline-Induced Eosinophilic Pneumonia in a Pediatric Patient

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