Chronic escitalopram treatment restores spatial learning, monoamine levels, and hippocampal long-term potentiation in an animal model of depression

Bhagya, V.; Srikumar, B.N.; Raju, T.R.; Rao, B.S. Shankaranarayana

doi:10.1007/s00213-010-2054-x

Cited by 60 publications

(48 citation statements)

References 102 publications

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“…However, neither citalopram (10 or 200 nM) nor R-citalopram (5 or 100 nM) has a significant effect at matching concentrations. The potentiation of NMDA currents by escitalopram is also in line with a recent study on long-term potentiation (LTP), in which hippocampal LTP deficits induced by neonatal clomipramine manipulation were restored after 2 weeks of escitalopram treatment (Bhagya et al 2011). Additional studies to confirm these results will be valuable, since a possible excitatory effect of escitalopram on dopaminergic and NMDA receptor-mediated neurotransmission may have bearing on cognition (Schilstrom et al 2011).…”

Section: Neuronal Activities and Neuroadaptationsupporting

confidence: 64%

Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action

Zhong¹,

Haddjeri

Sanchéz

2011

Psychopharmacology

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Section: Neuronal Activities and Neuroadaptationsupporting

confidence: 64%

Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action

Zhong¹,

Haddjeri

Sanchéz

2011

Psychopharmacology

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“…A standard curve was generated via the preparation of 1 mg/mL stock solutions of standard 5-HT, norepinephrine (NE), and dopamine (DA), which were diluted to a concentration of 100 ng/mL of injection solution. Sample concentrations were determined using an external standard calibration curve and expressed as ng/g of tissue wet weight (Bhagya et al, 2011).…”

Section: Detection Of Monoamine Neurotransmitter Levelsmentioning

confidence: 99%

Involvement of norepinephrine and serotonin system in antidepressant-like effects of hederagenin in the rat model of unpredictable chronic mild stress-induced depression

Liang

Huang

Wang

et al. 2014

Pharmaceutical Biology

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Objective: This study compared the antidepressant ability of FAE with that of HG in mice and further investigated the antidepressant-like effects and potential mechanisms of HG in rats subjected to unpredictable chronic mild stress (UCMS). Materials and methods: Mice received FAE (50 mg/kg) and HG (20 mg/kg) once a day via intragastric administration (i.g.) for 3 weeks. The anxiolytic and antidepressant activities of FAE and HG were compared using elevated plus maze (EPM) and behavioral despair tests including tail suspension test (TST) and forced swimming test (FST), respectively. Antidepressant effects of HG (5 mg/kg) were assessed using the UCMS depressive rat model. Moreover, the levels of monoamine neurotransmitters and relevant gene expression in UCMS rats' hippocampi were determined through high-performance liquid chromatography with electrochemical detection and real-time polymerase chain reaction techniques. Results: The results of our preliminary screening test suggest that HG at 20 mg/kg, while not FAE at 50 mg/kg, significantly decreased the immobility in both TST and FST compared with the vehicle group when administered chronically; however, there were no significant differences observed between the HG and the FAE group. Chronic administration of HG failed to significantly reverse the altered crossing and rearing behavioral performance, time spent in the open arm and closed entries in the EPM, even if they showed an increased tendency, but HG significantly increased the percent of sucrose preference in the sucrose preference test (SPT) and decreased the immobility time in the FST. HG showed that significant increases of norepinephrine and serotonin levels and exhibited a tendency to increase the expression of 5-hydroxytryptamine (serotonin) 1A receptor mRNA, and to significantly decrease the expression of the mRNA for the serotonin transporter (5-HTT). However, there were no significant differences in the expression of the brain-derived neurotrophic factor. Conclusion: These findings confirm the antidepressant-like effects of HG in a behavioral despair test and UCMS rat model, which may be associated with monoamine neurotransmitters and 5-HTT mRNA expression.

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“…[411121517] Rats were placed on the central platform and allowed to obtain reward within 5 min duration, and trail was terminated immediately after all four baits had been consumed or when 5 min had passed. Each rat was given two trails per day.…”

Section: Methodsmentioning

confidence: 99%

Neuroprotective effect of Celastrus paniculatus on chronic stress-induced cognitive impairment

2016

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Objective:Several studies report that chronic stress results in impaired spatial learning and working memory and enhanced anxiety-like behavior. However, not many studies have looked into the possible ways of reversing stress-induced deficits. Celastrus paniculatus (CP), a traditional ayurvedic herbal medicine, was used to treat cognitive deficits in mentally retarded children. CP oil has been reported to have neuroprotective and antioxidant activities. However, the effects of CP oil on chronic stress-induced cognitive deficits are unclear. In the present study, we intended to analyze the neuroprotective effects of CP oil on stress-associated cognitive dysfunctions.Materials and Methods:Chronic stress was induced by subjecting rats to restrainers for 6 h a day for 21 days. CP oil (400, 600 mg/kg) or vehicle was administered intraperitoneally (i.p.) after stress protocol once a day over the next 14 days. Groups used in the present study: normal control, stress, stress + vehicle, stress + CP oil at 2 different doses (400 and 600 mg/kg, i.p.). After the drug treatment, open field and elevated plus maze (EPM) were used to analyze anxiety-like behavior, and partially baited radial arm maze (RAM) and T-maze were used to evaluate spatial learning and memory capabilities. Analysis has been done using two-way ANOVA followed by Bonferroni's post hoc test and one-way ANOVA followed by Tukey's post hoc test.Results:Stressed rats showed enhanced anxiety-like behavior in EPM (P < 0.001) and impaired performance in RAM (P < 0.001) and T-maze tasks (P < 0.001) compared to normal animals. In contrast, CP oil treatment to these rats improved their performance in both RAM (P < 0.001) and T-maze (P < 0.001). In addition, CP oil significantly reduced stress-induced anxiety behavior (P < 0.001).Conclusion:Chronic treatment with CP oil is to improve cognitive abilities in chronically stressed rats. The current study provides a novel perspective on beneficial effect of herbal therapy on stress-induced cognitive dysfunctions.

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Chronic escitalopram treatment restores spatial learning, monoamine levels, and hippocampal long-term potentiation in an animal model of depression

Cited by 60 publications

References 102 publications

Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action

Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action

Involvement of norepinephrine and serotonin system in antidepressant-like effects of hederagenin in the rat model of unpredictable chronic mild stress-induced depression

Neuroprotective effect of Celastrus paniculatus on chronic stress-induced cognitive impairment

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