Chronic ethanol consumption alters cardiovascular functions in conscious rats

Antihypertensive and antioxidant effects of Allanblackia floribunda Oliv. (Clusiaceae) aqueous extract in alcohol- and sucrose-induced hypertensive rats

“…Ethanol treatment did not affect the heart rate in our experiment. Similar results were observed by Resstel et al (2005) who obtained no change in the resting heart rate of rats treated with 3. Effect of Allanblackia floribunda on tissues SOD levels of alcohol (A)-or sucrose (B)-induced hypertensive rats after 8 weeks of treatment.…”

“…The main factors contributing to the development of hypertension is the high consumption of salt, alcohol and sugar that have been obviously shown to induce cardiovascular dysfunction (Resstel et al, 2005;Kasdallah-Grissa et al, 2006;Johnson et al, 2007). It was demonstrated that intracellular Ca 2+ in a vascular smooth muscle cell preparation, even in the presence of Ca 2+ channel blockade, increases with ethanol (Vasdev et al, 1991).…”

Ethanol Consumption Enhances Endothelin-1-Induced Contraction in the Isolated Rat Carotid

“…Rats from the isocaloric group received a solution containing an isocaloric amount of sucrose (290.5 g/l) instead of ethanol. Rats in the ethanol group received 20% (v/v) ethanol in their drinking water (Resstel et al, 2006;. To avoid a considerable loss of animals, the ethanoltreated group was submitted to a brief and gradual adaptation period.…”

“…Epidemiological and clinical studies have established a positive relationship between long-term ingestion of ethanol and the development of hypertension (Resstel et al, 2006), brain ischemia, and stroke-like events (Altura et al, 1983;Gill et al, 1991;Kitohara et al, 1995). Ethanol consumption results in atrophy of cerebral areas that may be related to a reduction in cerebral blood flow (Melgaard et al, 1990;Oishi et al, 1999).…”

Efeitos do estresse crônico sobre as respostas cardiovasculares e ventilatórias ativadas pelo quimiorreflexo e barorreflexo em ratos

“…Vários estudos na literatura demonstram que uma das formas de avaliar a sensibilidade barorreflexa é através da quantificação da resposta reflexa de FC frente às variações de PA desencadeadas por drogas vasoativas (Crestani et al, 2006, Resstel et al, 2006b, Crestani et al, 2010a, Engi et al, 2012. No entanto, neste estudo a sensibilidade do barorreflexo também foi avaliada no domínio do tempo por meio do método da sequência.…”