Chronic Ethanol Exposure During Adolescence Increases Basal Dopamine in the Nucleus Accumbens Septi During Adulthood

Badanich, Kimberly A.; Maldonado, Antoniette M.; Kirstein, Cheryl L.

doi:10.1111/j.1530-0277.2007.00370.x

Cited by 61 publications

(67 citation statements)

References 48 publications

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“…For example, the connections among rewardrelated subcortical regions, as well as the neurocircuitry connecting the prefrontal cortex and these regions, continue to develop during adolescence (see review in DoremusFitzwater et al (2010)). There is also evidence that chronic ethanol administration during adolescence may alter adult brain functioning (Badanich et al 2007;Sahr et al 2004), which in turn could increase the reward value of ethanol and consequently the risks of alcohol-related problems in adulthood. However, further studies, especially with high ethanol doses, will be required to assess the repercussions in adulthood of an ethanol-induced sensitization that developed during adolescence.…”

Section: Discussionmentioning

confidence: 98%

Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice

et al. 2011

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Section: Discussionmentioning

confidence: 98%

Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice

et al. 2011

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“…Fetal alcohol exposure clearly contributes to physical anomalies in humans 14 and animals. 17 Animal research has shown that repeated alcohol exposure during adolescence induces inflammatory cell death, 26 as well as morphologic and neurochemical changes in the brain that may persist into adulthood, 27,28 although studies have yet to explore whether adults would be less vulnerable to these effects than adolescents. Research with human adolescents indicates that severe AUD is associated with reduced hippocampal volume, 29,30 although these results should not be interpreted as necessarily being causal.…”

Section: Development Itself May Be Altered By Alcohol Exposurementioning

confidence: 99%

Underage Drinking: A Developmental Framework

et al. 2008

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A developmental framework for understanding and addressing the problem of underage alcohol consumption is presented. The first section presents the rationale for a developmental approach, including striking age-related data on patterns of onset, prevalence, and course of alcohol use and disorders in young people. The second section examines the fundamental meaning of a developmental approach to conceptualizing underage drinking. The third section delineates contemporary principles of developmental psychopathology as a guide to future research and intervention efforts. Strategic, sensitive, and effective efforts to address the problem of underage drinking will require a developmentally informed approach to research, prevention, and treatment. D EVELOPMENTAL APPROACHES TO understanding and addressing the problem of underage drinking are essential, not only because this problem occurs in a developing organism but also because accumulating evidence strongly implicates the role of development in promising theories and interventions concerning this problem. It is increasingly clear that the emergence and progression of drinking behavior are influenced by development, that underage drinking has developmental consequences, that alcohol use disorders (AUDs) are developmental in nature, and that efforts to prevent or to reduce underage drinking behavior must be developmentally informed to be strategic, sensitive, and effective. Our goals in this article are to summarize the case for a developmental perspective on underage drinking and to outline a developmental framework for underage drinking, to guide future theory, research, and practice. This framework emerged from the collaborative work of an advisory group assembled by the National Institute on Alcohol Abuse and Alcoholism in 2004 as part of the Underage Drinking Research Initiative.The framework is presented in 3 sections. In the first section, we highlight the rationale for a developmental approach, including examples of data that the advisory group members found compelling as a rationale for developmental perspectives. In the second section, we discuss general developmental principles that guided our thinking, with examples of their application to drinking behavior. In the third section, we articulate principles of contemporary developmental psychopathology as applied to the problem of underage drinking. RATIONALE FOR A DEVELOPMENTAL APPROACH TO UNDERAGE DRINKING FocusWhen the evidence on drinking behavior is examined through a developmental lens, the rationale for a developmental approach to understanding and preventing this problem comes into focus. In this section, we highlight conclusions based on the most salient data supporting a developmental approach.There Are Striking Age-Related Patterns of Alcohol Use, Problems, Abuse, and Dependence Alcohol use typically begins in the second decade of life, often in early adolescence. Although some young people begin drinking in elementary school, the first use of alcohol (defined as drinking a whole drink) typ...

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“…Multiple studies have indicated that systemic administration of EtOH during adolescence results in higher basal DA levels in the Acb (Badanich et al, 2007;Pascual et al, 2009). Comparable EtOH injections in adolescent and adult rats result in higher basal level of DA in the Acb in adolescent rats (Pascual et al, 2009).…”

Section: Adolescent Etoh Adult Mesolimbic Dopaminementioning

confidence: 99%

“…Adolescent EtOH consumption (Sahr et al, 2004), as well as peripheral EtOH injections (Badanich et al, 2007), can increase basal DA levels or DA reuptake in the Acb shell (AcbSh) during adulthood. Similar results are not produced in adult rats with comparable EtOH exposure paradigms (Pascual et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Reinforcing Properties and Neurochemical Response of Ethanol within the Posterior Ventral Tegmental Area Are Enhanced in Adulthood by Periadolescent Ethanol Consumption

Toalston

Deehan

Hauser

et al. 2014

J Pharmacol Exp Ther

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Alcohol drinking during adolescence is associated with increased alcohol drinking and alcohol dependence in adulthood. Research examining the biologic consequences of adolescent ethanol (EtOH) consumption on the response to EtOH in the neurocircuitry shown to regulate drug reinforcement is limited. The experiments were designed to determine the effects of periadolescent alcohol drinking on the reinforcing properties of EtOH within the posterior ventral tegmental area (pVTA) and the ability of EtOH microinjected into the pVTA to stimulate dopamine (DA) release in the nucleus accumbens shell (AcbSh). EtOH access (24-hour free-choice) by alcohol-preferring rats occurred during postnatal days (PND) 30-60. Animals were tested for their response to EtOH after PND 85. Intracranial self-administration techniques were performed to assess EtOH self-infusion into the pVTA. In the second experiment, rats received microinjections of EtOH into the pVTA, and dialysis samples were collected from the AcbSh. The results indicate that in rats that consumed EtOH during adolescence, the pVTA was more sensitive to the reinforcing effects of EtOH (a lower concentration of EtOH supported self-administration) and the ability of EtOH microinjected into the pVTA to stimulate DA release in the AcbSh was enhanced (sensitivity and magnitude). The data indicate that EtOH consumption during adolescence altered the mesolimbic DA system to be more sensitive and responsive to EtOH. This increase in the response to EtOH within the mesolimbic DA during adulthood could be part of biologic sequelae that are the basis for the deleterious effects of adolescent alcohol consumption on the rate of alcoholism during adulthood.

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Chronic Ethanol Exposure During Adolescence Increases Basal Dopamine in the Nucleus Accumbens Septi During Adulthood

Abstract: Together these findings suggest that changes in extracellular DA may be an underlying physiological mechanism in adolescent vulnerability to the rewarding properties of ethanol.

Cited by 61 publications

References 48 publications

Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice

Developmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice

Underage Drinking: A Developmental Framework

Reinforcing Properties and Neurochemical Response of Ethanol within the Posterior Ventral Tegmental Area Are Enhanced in Adulthood by Periadolescent Ethanol Consumption

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