Chronic exercise increases SNAP-25 abundance in fast-transported proteins of rat motoneurones

Changming, Kang; Lavoie, P.‐A.; Gardiner, Phillip F.

doi:10.1097/00001756-199502000-00035

Cited by 25 publications

(18 citation statements)

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“…The mechanisms that promote these changes in motoneuron properties are not known, but may involve upregulation of neurotrophins. Changes previously noted in motoneurons of rats subjected to endurance training include increased oxidative enzyme activity,47 fast axon transport,32 and neuromuscular transmission dynamics 9, 10. Recently, evidence has been presented suggesting that 7 days of daily exercise in rats results in increased expression in spinal cord of neurotrophin‐3 (NT‐3), brain‐derived neurotrophic factor (BDNF), trkB receptors, and synapsin I 20, 21, 36.…”

Section: Discussionmentioning

confidence: 99%

“…The purpose of the present study was to determine whether motoneuron adaptations could be evoked in rats by subjecting them to a traditional endurance‐training program shown in past reports to evoke adaptations in muscle properties, motoneuron biochemical properties, and neuromuscular junctions 9, 18, 19, 30–32, 37, 45. Because endurance training involves a more intense recruitment of all motoneurons (as evidenced by more marked muscle fiber adaptations in fast muscles), but for a shorter total period of time, compared to spontaneous wheel‐running, it may be possible to distinguish the importance of total time versus intensity of motor unit use on the previously noted biophysical adaptations in hindlimb motoneurons.…”

mentioning

confidence: 98%

“…For example, there is some suggestion that motoneurons, like other neuron types, may show increased oxidative enzyme levels when subjected to increased activation 4, 28, 38, 47, 48. Increases also occur in the amount and rate of transport of proteins via fast axonal transport, in axons innervating the hindlimb muscles of endurance‐trained rats 18, 31, 32…”

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confidence: 99%

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Endurance training alters the biophysical properties of hindlimb motoneurons in rats

Beaumont

Gardiner

2002

Muscle and Nerve

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The purpose of the study was to determine the effect of daily endurance treadmill training (2 h/day, 30 m/min) on motoneuron biophysical properties. Electrophysiological properties of tibial motoneurons were measured in situ in anesthetized (ketamine/xylazine) control and trained rats using sharp glass microelectrodes. Motoneurons from trained rats had significantly hyperpolarized resting membrane potentials and spike trigger levels, and faster antidromic spike rise-times. "Fast" motoneurons (after-hyperpolarization half-decay time <20 ms) in trained rats also had a significantly larger mean cell capacitance than those in control rats, suggesting that they were larger, although this had no effect on indices of excitability (rheobase, cell input resistance). Motoneurons are thus targets for activity-induced adaptations, which may have clinical significance for the role of physical activity as a therapeutic modality in cases of neurological deficit. The specific adaptations noted, which reflect alterations in ionic conductances, may serve to offset decreases in membrane excitability that occur during sustained excitation.

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Section: Discussionmentioning

confidence: 99%

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confidence: 98%

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Endurance training alters the biophysical properties of hindlimb motoneurons in rats

Beaumont

Gardiner

2002

Muscle and Nerve

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“…After training, motoneurons can transport more axonal protein, through either forward or reverse transport, and thus improve the overall adaptability of the motor units. For example, synaptic protein SNAP25 links synaptic vesicles and presynaptic membrane and motor neuron axons transport synaptic proteins SNAP25 with high selectivity after training [38]. Other proteins, such as the enzyme malate dehydrogenase and the trophic factor calcitonin gene-related peptide, are present in higher amounts in the motoneurons.…”

Section: Effect On Cell Biochemistry/metabolismmentioning

confidence: 99%

Exercise Training Promotes Functional Recovery after Spinal Cord Injury

Wang

Deng

et al. 2016

Neural Plasticity

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The exercise training is an effective therapy for spinal cord injury which has been applied to clinic. Traditionally, the exercise training has been considered to improve spinal cord function only through enhancement, compensation, and replacement of the remaining function of nerve and muscle. Recently, accumulating evidences indicated that exercise training can improve the function in different levels from end-effector organ such as skeletal muscle to cerebral cortex through reshaping skeletal muscle structure and muscle fiber type, regulating physiological and metabolic function of motor neurons in the spinal cord and remodeling function of the cerebral cortex. We compiled published data collected in different animal models and clinical studies into a succinct review of the current state of knowledge.

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“…Degenerative processes in the central nervous system (selective loss of fast α-motor neurons) and/or peripheral nervous system, as well as inactivity and altered thyroid hormone levels, may all contribute to the observed atrophy and potential loss of fast motor units and fast fibers. Exercise has been shown to enhance fast axonal transport in rat muscle (Gharakhanlou et al 1999;Jasmin et al 1988;Kang et al 1995). In addition, there appears to be a reduced number of motor units with increased size in aging muscles (Booth et al 1994).…”

Section: Agingmentioning

confidence: 99%

Transitions of muscle fiber phenotypic profiles

Pette

Staron

2001

Histochem Cell Biol

417

196

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Skeletal muscle is a complex, versatile tissue composed of a large variety of functionally diverse fiber types. The overall properties of a muscle largely result from a combination of the individual properties of its different fiber types and their proportions. Skeletal muscle fiber types, which can be delineated according to various parameters, for example, myofibrillar protein isoforms, metabolic enzyme profiles, and structural and contractile properties, are not fixed units but are capable of responding to altered functional demands and a variety of signals by changing their phenotypic profiles. This brief review summarizes our current understanding of the delineation of fiber types, modulations of their phenotypic profiles as induced under various conditions, and potential mechanisms involved in these transitions.

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Chronic exercise increases SNAP-25 abundance in fast-transported proteins of rat motoneurones

Cited by 25 publications

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Endurance training alters the biophysical properties of hindlimb motoneurons in rats

Endurance training alters the biophysical properties of hindlimb motoneurons in rats

Exercise Training Promotes Functional Recovery after Spinal Cord Injury

Transitions of muscle fiber phenotypic profiles

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