Chronic Exogenous Exophiala Dermatitidis Endophthalmitis

Clamp, Michael F.; Jumper, J. Michael; Ku, Christine W.; McDonald, H. Richard; Johnson, Robert N.; Fu, Arthur D.; Lujan, Brandon J.; Cunningham, Emmett T.

doi:10.1097/icb.0000000000000097

Cited by 11 publications

(9 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…) and a patient with chronic exogenous endophthalmitis caused by this agent were also described (Clamp et al. ). Two case reports of patients with keratitis caused by E. jeanselmei have been published, one in a patient after ocular trauma with onion (Al‐hedaitht & Al‐Kaff ; Ben‐Simon et al.…”

Section: Discussionmentioning

confidence: 98%

Exophiala phaeomuriformis keratitis in a subarctic climate region: a case report

Vicente

Domellöf

Byström

2017

Acta Ophthalmologica

View full text Add to dashboard Cite

This is the first described case of keratitis caused by E. phaeomuriformis in a subarctic region, the first in Europe and, to our knowledge, the second reported case in the literature. It is important to remember that superficial corneal brown-pigmented infiltrates should raise the suspicion of an unusual fungal infection even in this climate. This is particularly important in patients with ocular surface disease treated with steroids and antibiotics for a long time.

show abstract

Section: Discussionmentioning

confidence: 98%

Exophiala phaeomuriformis keratitis in a subarctic climate region: a case report

Vicente

Domellöf

Byström

2017

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…There is no tendency for certain species of Exophiala to have a higher affinity towards certain parts of the eye. However, E. jeanselmei and E. dermatitidis have higher affinities to the human eye than the other species do [3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Interestingly, in the past 5 years, E. phaeomuriformis has been reported as a causative strain of eye infections.…”

Section: Discussionmentioning

confidence: 99%

“…Of the eye infections caused by the Exophiala species, we found 19 case reports in the English literature, which identified the species of the causative strains. At present, four species, namely E. dermatitidis, E. jeanselmei, E. phaeomuriformis, and E. werneckii, have been reported to be the causative species of eye infections [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Orbital abscess caused by Exophiala dermatitidis following posterior subtenon injection of triamcinolone acetonide: a case report and a review of literature related to Exophiala eye infections

et al. 2020

View full text Add to dashboard Cite

Background: Subtenon injection of triamcinolone acetonide (STTA) has been widely adopted in the clinical setting of ophthalmology and its infectious complications are rare. However, orbital abscess following STTA has been reported in seven cases. Furthermore, although eye infections due to Exophiala species are uncommon, there have been 19 cases to date. E. jeanselmei, E. phaeomuriformis, E. werneckii, and E. dermatitidis have been reported to cause human eye infections; however, to the best of our knowledge, orbital abscess caused by E. dermatitidis has not yet been reported. We describe the first documented case of fungal orbital abscess caused by E. dermatitidis following STTA. We also review the related literature of orbital abscess following STTA, as well as eye infections caused by the four Exophiala species. Case presentation: The patient was a 69-year-old Japanese woman with diabetic mellitus. She had a macular oedema in her right eye, which occurred secondary to branch retinal vein occlusion. An orbital abscess caused by E. dermatitidis occurred 4 months after the second STTA for the macular oedema, which was successfully treated by a surgical debridement and systemic administration of voriconazole. Conclusions: Our findings in the patient and from our literature survey caution ophthalmologists to the fact that STTA can cause fungal orbital infections, especially in diabetic patients. Furthermore, surgical treatment is one of the most important risk factors.

show abstract

“…and amphotericin B eye drops (0.15% (w/v) eight times a day). A failed therapeutic approach and consequent enucleation of the blind eyes were reported in the cases of Margo et al [14] and Clamp et al [17].…”

Section: Discussionmentioning

confidence: 97%

“…Most cases occur after a penetrating injury or post eye surgery [6]. Though the presented case is the fourth documented case of endophthalmitis caused by E. dermatitidis across the globe according to a deep search of the available literature (Table 1) [7][8][9][10][11][12][13][14][15][16][17][18], it is unique, as it is the first report with a successful treatment outcome. Human ocular infection due to E. dermatitidis has not been documented in India before.…”

Section: Introductionmentioning

confidence: 99%

Exophiala dermatitidis Endophthalmitis: Case Report and Literature Review

et al. 2018

View full text Add to dashboard Cite

We report a case of a 59-year-old male patient with a postoperative fungal infection of the left eye. A dark-pigmented yeast, Exophiala dermatitidis (previously known as Wangiella dermatitidis), was identified from the culture of the biopsy taken from the posterior capsule. The infection was successfully eradicated by a combination of surgical and medical (i.e., voriconazole and fluconazole) treatment. This is the first report of successfully treated E. dermatitidis endophthalmitis, which demonstrates that a prompt and aggressive antifungal therapy combined with surgical intervention is necessary to prevent vision loss in cases of endophthalmitis due to Exophiala species. Beside the case description, we also aim to provide a literature review of previously reported eye infections caused by Exophiala species in order to help the future diagnosis and management of the disease.

show abstract

Chronic Exogenous Exophiala Dermatitidis Endophthalmitis

Abstract: Although rare, Exophiala species can cause exogenous endophthalmitis. Chronic endophthalmitis should be suspected in patients who develop persistent intraocular inflammation after infectious keratitis.

Cited by 11 publications

References 11 publications

Exophiala phaeomuriformis keratitis in a subarctic climate region: a case report

Exophiala phaeomuriformis keratitis in a subarctic climate region: a case report

Orbital abscess caused by Exophiala dermatitidis following posterior subtenon injection of triamcinolone acetonide: a case report and a review of literature related to Exophiala eye infections

Exophiala dermatitidis Endophthalmitis: Case Report and Literature Review

Contact Info

Product

Resources

About