Chronic Experimental Hypertension in Dogs after Constriction of Brachiocephalic and Left Subclavian Arteries

Hawthorne, Edward W.; Mandal, Anil K.

doi:10.1161/01.res.11.1.153

Cited by 9 publications

(6 citation statements)

References 13 publications

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“…It is very possible the brachiocephalic artery was leaking slowly from the previous day and then burst open just before the animal died. Hawthorne and Manda [2] induced brachiocephalic rupture by simultaneous constriction of the left subclavian and brachiocephalic artery. This caused sudden death due to brachiocephalic rupture in a few of the dogs after a 4-week period.…”

Section: Discussionmentioning

confidence: 97%

“…Brachiocephalic artery rupture as a cause of death in dogs has only been reported twice before [1,2]. According to Hawthorne and Mandal, the rupture of the brachiocephalic artery was caused by intentional constriction of the subclavian and brachiocephalic arteries in order to investigate how increased blood pressure would affect the brachiocephalic artery [2].…”

Section: Discussionmentioning

confidence: 99%

“…According to Hawthorne and Mandal, the rupture of the brachiocephalic artery was caused by intentional constriction of the subclavian and brachiocephalic arteries in order to investigate how increased blood pressure would affect the brachiocephalic artery [2]. In the second case [1] the immediate cause of death was massive haemorrhage into the mediastinum.…”

Section: Discussionmentioning

confidence: 99%

“…It should be noted, however, that unlike the 3 year old dog in Arimura, Machida [1] case, our patient was only 10 months old, an age that does not lend this bitch to be an ideal candidate for degenerative changes associated with the former case. An equally compelling argument could be that, the degenerative changes in the arterial wall could have been associated with a distal constriction and hypertension as observed by Hawthorne and Mandal [2] and possibly aneurysm observed by Soylu, Harling [5] and Saito, Shiono [6] as a possible cause of rupture of the innominate artery in humans.…”

Section: Discussionmentioning

confidence: 99%

“…Brachiocephalic artery rupture is a very rare condition in dogs and has only been reported twice in literature of recent years [1,2]. Herein, is described a case of a 10 month old Boston terrier bitch that died of brachiocephalic artery rupture whose cause could not be determined.…”

Section: Introductionmentioning

confidence: 96%

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Introduction: Brachiocephalic artery rupture is a very rare and fatal condition in dogs that is likely to be missed during clinical examination and would normally be diagnosed at post mortem. The aetiology is unknown but is most likely multifactorial and associated with arterial wall degeneration leading to rupture and sudden death due to massive haemorrhage resulting in death from hypovolemic shock. Case Presentation: An intact (unspayed) Boston terrier bitch was admitted into the clinic for sudden onset lethargy. Ante-mortem differential diagnoses which included shocked lung, lung bleeding, diaphragmatic hernia, babesiosis, verminosis and internal bleeding were considered based on history, physical examination, clinical pathology and plain radiography. Conclusions: A definitive diagnosis of fatal brachiocephalic artery rupture was reached at post-mortem examination, performed pro-bono, out of interest with the owner's permission. Ante-mortem diagnosis of brachiocephalic artery rupture is still an unsolved challenge for the practising veterinarian, notwithstanding the recent advances in diagnostics. Fatal brachiocephalic rupture is a rare condition and only has been reported in dogs twice previously.

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Section: Discussionmentioning

confidence: 97%