Chronic exposure of Brown (Hydra oligactis) and green Hydra (Hydra viridissima) to environmentally relevant concentrations of pharmaceuticals

Lee, Abigail H.; Fraz, Shamaila; Purohit, Ushma; Campos, Ana Regina Nascimento; Wilson, Joanna Y.

doi:10.1016/j.scitotenv.2020.139232

Cited by 10 publications

(7 citation statements)

References 58 publications

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“…For instance, for CAP, no effective concentrations could be delivered when assessing its effects on zebrafish, whilst the same happens in 5-FU with the green microalgae. Despite that, the sublethal endpoints tested for H. viridissima were sensitive and informative of potential cellular, individual, and population disruptive levels of these cytostatics (Lee et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Assessing the risks of capecitabine and its active metabolite 5-fluorouracil to freshwater biota

Venâncio

Monteiro

Lopes

et al. 2023

Environ Sci Pollut Res

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Capecitabine (CAP, prodrug) and 5-fluorouracil (5-FU, its active metabolite) are two of the most prominent cytostatics, for which no clear picture can be drawn regarding potential concentrations of effect for freshwater biota, with CAP being grouped in the least studied cytostatic, whereas 5-FU has been classified as of no and of high environmental risk. Accordingly, the present work aimed to assess the ecotoxicity of CAP and 5-FU in three freshwater species, which included a 72-h assay with the producer Raphidocelis subcapitata; a 96-h assay with the invertebrate secondary consumer Hydra viridissima; and a 96-h assay with embryos of the vertebrate secondary consumer Danio rerio. The following endpoints were monitored: yield and population growth rate for the algae; mortality, morphological alterations, and post-exposure feeding rates for the cnidarian; and mortality, hatching, and malformations for the fish. Overall, organisms’ sensitivity to CAP decreased in the following order: R. subcapitata > H. viridissima > D. rerio, whereas for 5-FU, it decreased in the following order: H. viridissima > D. rerio > R. subcapitata. For CAP, no median lethal effective concentrations (LC/EC50) were possible to compute for D. rerio, with no significant mortality or malformations registered in embryos exposed at concentrations up to 800 mg L−1. For R. subcapitata, the EC50s were 0.077 and 0.63 mg L−1 for yield and growth rate, respectively, and for H. viridissima, the EC50,30 min for feeding was 22.0 mg L−1. For 5-FU, no EC50s could be computed for R. subcapitata, whilst the EC50s for H. viridissima mortality and feeding were 55.4 and 67.9 mg L−1, respectively, and for D. rerio, the LC50,96 h and EC50,96 h (hatching and abnormalities) were 4546, 4100, and 2459 mg L−1, respectively. Assuming similar modes of action for both compounds and their co-occurrence, the combined risk quotient of the two chemicals was determined to be 7.97, which represents a risk for freshwater biota. Anticipating the increased consumption of these compounds and cancer development trends worldwide, these impacts may be further aggravated.

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Section: Discussionmentioning

confidence: 99%

Assessing the risks of capecitabine and its active metabolite 5-fluorouracil to freshwater biota

Venâncio

Monteiro

Lopes

et al. 2023

Environ Sci Pollut Res

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“…Hydra vulgaris Pallas 1766 (conocida también como H. attenuata) (Anthoathecata: Hydridae) se ha utilizado para evaluar la toxicidad de numerosos contaminantes (MacKinley et al, 2019) como desreguladores endocrinos, nanomateriales, compuestos metálicos, efluentes industriales, agua potable y agua cruda Trottier et al, 1997;Díaz et al, 2004;Quinn et al, 2012;Murphy & Quinn, 2018;Espinosa, 2018;Barrera et al, 2019;Auclair et al, 2020). Mientras que Hydra viridissima Pallas 1766 es preferida en evaluaciones de fármacos, nanomateriales y mezclas de contaminantes (Tökölyi et al, 2014;Prouse et al, 2015;Venâncio et al, 2020;Lee et al, 2020).…”

Section: Introductionunclassified

“…Este trabajo evaluó la sensibilidad de H. vulgaris a la toxicidad al NaCl comparativamente con H. viridissima, la última posee una asociación mutualista con el alga simbionte Chlorella vulgaris Beijerinck 1890 (Kawaida et al, 2013;Kobayakawa, 2017), con el propósito de identificar respuestas diferenciadas a los estresores ambientales a nivel de género (Lee et al, 2020). Se obtuvo información sobre la tasa de crecimiento (como medida del crecimiento de la población) y las concentraciones: efectiva media (CE 50 ) y letal media (CL 50 ) como respuesta a concentraciones crecientes de NaCl con valoración por cambios morfológicos de tentáculos y columnella.…”

Section: Introductionunclassified

Comparación ecotoxicológica al Cloruro de Sodio en Hydra vulgaris e Hydra viridissima

Barrera Herrera,

Espinosa Ramírez

2023

Rev. colomb. biotecnol.

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El aumento de la salinidad en los ecosistemas de agua dulce genera preocupación sobre los efectos adversos que puede provocar sobre las especies dulceacuícolas y el suelo. Las concentraciones óptimas de iones de sodio y calcio para que las especies del género Hydra tengan condiciones fisiológicas adecuadas son relativamente bajas. Este trabajo se enfocó en comparar la sensibilidad de H. vulgaris e H. viridissima frente al cloruro de sodio (NaCl). Las especies fueron mantenidas bajo condiciones de fotoperiodo, iluminación y temperatura controladas. Se obtuvieron las tasas de crecimiento y en ensayos de toxicidad aguda se calcularon las CE50 (Concentración efectiva media) y CL50 (Concentración letal media) como indicadores de la sensibilidad al NaCl. H. vulgaris fue más sensible al NaCl dado que la CL50-96h fue de 1,0 g/l NaCl (entre 0,8 – 1,2 g/l como intervalo de confianza al 95%), mientras que H. viridissima presentó una CL50-96h promedio de 2,6 g/l (entre 2,0 – 3,3 g/l como intervalo de confianza del 95%). Se considera que esta última fue más tolerante al NaCl, probablemente por la relación simbiótica con la microalga Chlorella vulgaris, ya que podría generar un efecto protector. Se espera que comprender el comportamiento de estos biomodelos respecto al aumento de la salinización permita la evaluación temprana de riesgos ecológicos en ecosistemas acuáticos tropicales.

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“…The innovation in modern technology improved the analytical capabilities, which manifested the wide range of pharmaceuticals in the environment. Wastewater has long-term effects on the ecological health of human beings, such as acute and chronic effects (13), behavioral changes (14), and reproductive damage (15). Current studies indicate that pharmaceuticals have also affected aquatic life.…”

Section: Introductionmentioning

confidence: 99%

Impact Of Irrigation Water On the Quality Attributes of Selected Indigenous Plants

Ullah

Shahbaz

ASLAM

2022

Journal of the Turkish Chemical Society Section A: Chemistry

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The present study was carried out to study the effects of irrigation water on the quality attributes of mango, banana, and mulberry collected from the nearby orchards located in peri-urban areas of Sahiwal (Pakistan). Due to freshwater scarcity in peri-urban areas, wastewater is used as a source of irrigation for orchards, which consequently increases heavy metal accumulation in the soil, leaves, and fruits. The physio-chemical attributes and accumulation of heavy metals were analyzed in different soil layers and fruit cultivars. Among the heavy metals, copper, lead, chromium, and cadmium contents were found to be in greater amounts in the effluent sample than in freshwater samples, according to WHO. Heavy metals such as copper, lead, and chromium were found to be in higher concentrations in soil and effluent samples. The concentration levels of copper in mango and mulberry were 0.005 and 0.002 mg/kg, respectively. The concentration levels of lead in banana and mulberry were 0.231 and 1.248 mg/kg, and the concentration of chromium in banana was found to be 1.203 mg/kg, which is higher than the allowed limit given by WHO. The interaction among the sources of irrigation and fruit cultivars was significant for copper accumulation in different soil layers, lead, and copper accumulation in fruit cultivars. The irrigation water quality index (WQI) of all effluent samples ranged from 63.5 to 63.57, which, according to WHO, can be used for irrigation purposes as it is nondrinkable water.

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Chronic exposure of Brown (Hydra oligactis) and green Hydra (Hydra viridissima) to environmentally relevant concentrations of pharmaceuticals

Cited by 10 publications

References 58 publications

Assessing the risks of capecitabine and its active metabolite 5-fluorouracil to freshwater biota

Assessing the risks of capecitabine and its active metabolite 5-fluorouracil to freshwater biota

Comparación ecotoxicológica al Cloruro de Sodio en Hydra vulgaris e Hydra viridissima

Impact Of Irrigation Water On the Quality Attributes of Selected Indigenous Plants

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