Chronic exposure of juvenile rats to environmental noise impairs hippocampal cell proliferation in adulthood

Jáuregui-Huerta, Fernando; Garcı́a-Estrada, Joaquı́n; Ruvalcaba-Delgadillo, Yaveth; Trujillo, Xóchitl; Huerta, Miguel; Feria‐Velasco, Alfredo; González-Pérez, Óscar; Luquı́n, Sonia

doi:10.4103/1463-1741.82961

Cited by 32 publications

(25 citation statements)

References 36 publications

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“…For exposure to mild stress at the early stages of life, the rats were exposed to an audiogram-fitted noisy environment (kindly provided by Dr. A. Rabat). Noise is a known ubiquitous stimulus that is capable of inducing a moderate stress response (Rabat et al, 2004 ; Jauregui-Huerta et al, 2010a ; Jáuregui-Huerta et al, 2011 ). Urban audio files containing unpredictable noise events, with a duration ranging from 18 to 39 s and spaced by silent intervals ranging from 20–165 s, were randomly presented to rats for 24 h throughout the 15 days following weaning (i.e., PNDs 21–35).…”

Section: Methodsmentioning

confidence: 99%

Hippocampal cytogenesis and spatial learning in senile rats exposed to chronic variable stress: effects of previous early life exposure to mild stress

Jáuregui-Huerta

Zhang

Yañez-Delgadillo

et al. 2015

Front. Aging Neurosci.

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In this study, we exposed adult rats to chronic variable stress (CVS) and tested the hypothesis that previous early-life exposure to stress changes the manner in which older subjects respond to aversive conditions. To this end, we analyzed the cytogenic changes in the hippocampus and hippocampal-dependent spatial learning performance. The experiments were performed on 18-month-old male rats divided into four groups as follows: Control (old rats under standard laboratory conditions), Early-life stress (ELS; old rats who were exposed to environmental noise from postnatal days, PNDs 21–35), CVS + ELS (old rats exposed to a chronic stress protocol who were previously exposed to the early-life noise stress) and CVS (old rats who were exposed only to the chronic stress protocol). The Morris Water Maze (MWM) was employed to evaluate the spatial learning abilities of the rats at the end of the experiment. Immunohistochemistry against 5′Bromodeoxyuridine (BrdU) and glial fibrillar acidic protein (GFAP) was also conducted in the DG, CA1, CA2 and CA3 regions of the hippocampus. We confocally analyzed the cytogenic (BrdU-labeled cells) and astrogenic (BrdU + GFAP-labeled cells) changes produced by these conditions. Using this procedure, we found that stress diminished the total number of BrdU+ cells over the main proliferative area of the hippocampus (i.e., the dentate gyrus, DG) but increased the astrocyte phenotypes (GFAP + BrdU). The depleted BrdU+ cells were restored when the senile rats also experienced stress at the early stages of life. The MWM assessment demonstrated that stress also impairs the ability of the rats to learn the task. This impairment was not present when the stressful experience was preceded by the early-life exposure. Thus, our results support the idea that previous exposure to mild stressing agents may have beneficial effects on aged subjects.

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Section: Methodsmentioning

confidence: 99%

Hippocampal cytogenesis and spatial learning in senile rats exposed to chronic variable stress: effects of previous early life exposure to mild stress

Jáuregui-Huerta

Zhang

Yañez-Delgadillo

et al. 2015

Front. Aging Neurosci.

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“…However, the damaging effects of noise are not limited to the auditory system but rather extend to many other systems 5 . Recent studies have discussed the noise-related impairment of learning ability and cognitive performance 6 7 8 9 . Soldiers who were exposed to excessive noise levels, including explosions and blast waves, experienced severe noise-induced hearing loss (NIHL) and tinnitus 10 11 as well as cognitive deficits and memory impairment 12 .…”

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confidence: 99%

Noise induced hearing loss impairs spatial learning/memory and hippocampal neurogenesis in mice

Liu

Shen

et al. 2016

Sci Rep

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Hearing loss has been associated with cognitive decline in the elderly and is considered to be an independent risk factor for dementia. One of the most common causes for acquired sensorineural hearing loss is exposure to excessive noise, which has been found to impair learning ability and cognitive performance in human subjects and animal models. Noise exposure has also been found to depress neurogenesis in the hippocampus. However, the effect is mainly attributed to the oxidant stress of noise on the cognitive brain. In the present study, young adult CBA/CAJ mice (between 1.5 and 2 months of age) were briefly exposed a high sound level to produce moderate-to-severe hearing loss. In both the blood and hippocampus, only transient oxidative stress was observed after noise exposure. However, a deficit in spatial learning/memory was revealed 3 months after noise exposure. Moreover, the deficit was correlated with the degree of hearing loss and was associated with a decrease in neurogenesis in the hippocampus. We believe that the observed effects were likely due to hearing loss rather than the initial oxidant stress, which only lasted for a short period of time.

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“…The exposure to noise in our study had an opposite tendency of decreasing the CP ratio. This finding is reinforced by the report by Jáuregui-Huerta et al ( 2011 ) on exposure of rats to environmental noise associated with decreased cell proliferation in the hippocampal formation.…”

Section: Discussionmentioning

confidence: 55%

Can cell proliferation of umbilical cord blood cells reflect environmental exposures?

et al. 2015

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Environmental hazards were shown to have an impact on cell proliferation (CP). We investigated CP of lymphocytes in umbilical cord blood in relation to prenatal environmental exposures in a sample of 346 Arab-Bedouin women giving birth in a local hospital. Information on subjects’ addresses at pregnancy, potential household exposures and demographical status was collected in an interview during hospitalization. This population is usually featured by high rates of neonatal morbidity and multiple environmental exposures, originating from the local industrial park (IP), household hazards and frequent male smoking. A geometric mean CP ratio 2.17 (2.06; 2.29), and was high in women residing in a direction of prevailing winds from the local IP (p value = 0.094) and who gave birth during fall-winter season (p value = 0.024). Women complaining on disturbing exposure to noise had lower CP (p value = 0.015), compared to other women. CP was not indicative of neonatal morbidity. However, our findings suggest that CP of umbilical cord might be modified by environmental exposures. A long-term follow-up of the children is required to assess their developmental outcomes.

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Chronic exposure of juvenile rats to environmental noise impairs hippocampal cell proliferation in adulthood

Cited by 32 publications

References 36 publications

Hippocampal cytogenesis and spatial learning in senile rats exposed to chronic variable stress: effects of previous early life exposure to mild stress

Hippocampal cytogenesis and spatial learning in senile rats exposed to chronic variable stress: effects of previous early life exposure to mild stress

Noise induced hearing loss impairs spatial learning/memory and hippocampal neurogenesis in mice

Can cell proliferation of umbilical cord blood cells reflect environmental exposures?

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