Chronic exposure to 2.9 mT, 40 Hz magnetic field reduces melatonin concentrations in humans

Karasek, M; Woldańska-Okońska, Marta; Czernicki, Jan; Żylińska, Krystyna; Świętosławski, Jacek

doi:10.1111/j.1600-079x.1998.tb00393.x

Cited by 36 publications

(28 citation statements)

References 31 publications

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“…Support for this hypothesis was found in pinealectomy and constant-light studies, which indicate that eliminating the endogenous nOCturnalmelatonin signal enhances mammary tumorigenesis in female rats (5). Some studies have suggested inhibition of melatonin production in humans mediated by~F exposure (6)(7)(8)(9)(10)(11), while others have not (12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Population-Based Case-Control Study of Occupational Exposure to Electromagnetic Fields and Breast Cancer

Wijngaarden

Nylander‐French

Millikan

et al. 2001

Annals of Epidemiology

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PURPOSE: This population-based case-control study examined occupational exposure to electromagnetic fields in relation to female breast cancer incidence among 843 breast cancer cases and 773 controls. METIIODS: Exposure was classified based on work in the two longest-held jobs. and indices of cumu1at ive exposure to magnetic fields based on a measurement survey. , RESULTS: Female breast cancer was not associated with employment as an office or industrial worker. For the total study population, cumulative exposure ove~the entire career, and in the past 0-10 and 10-20 years generally showed odds mtios (ORs) close to the null Moderately elevated risks were found for intermediate but not high levels of cumulative exposure accumulated 20 or more yean; ago (OR == 1.5i 95% CI ::::1.1-2.0). Associations were stronger for premenopausal women (OR = 1.7; 95% CI = 1.1-2.7) in the past 10-20 years, and those with estrogen-receptor positive (ER +) breast tumorS (OR = 2.06; 95% CI 0:: 1.1-4.0). No consistent dose-response patterns were observed.CONCLUSIONS: These findings give little support to the hypothesiS that electromagnetic fields cause cancer of the female breast.Ann Epidemio! 2oql;

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Section: Introductionmentioning

confidence: 99%

Population-Based Case-Control Study of Occupational Exposure to Electromagnetic Fields and Breast Cancer

Wijngaarden

Nylander‐French

Millikan

et al. 2001

Annals of Epidemiology

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“…In a recent study, Karasek et al [1998] showed that 40 Hz daytime MF exposure induced a significant depression in nocturnal melatonin rise of patients with low back pain syndrome, regardless of time of exposure (10:00 or 18:00 hr). It is the first study to show that daytime MF exposure can influence night-time production of melatonin in controlled conditions.…”

Section: Discussionmentioning

confidence: 99%

“…However, it could be interesting to consider this known interindividual difference observed in healthy subjects [Bergiannaki et al, 1995], according to the divergent results related to this issue [Graham et al, 1996;Karasek et al, 1998;Wood et al, 1998]. …”

Section: Discussionmentioning

confidence: 99%

Daytime 50 Hz magnetic field exposure and plasma melatonin and urinary 6‐sulfatoxymelatonin concentration profiles in humans

Crasson

Beckers

Péqueux

et al. 2001

Journal of Pineal Research

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Concern about the health effects of extremely low frequency (ELF) magnetic fields (MF) has been raised by epidemiological studies indicating an association between certain cancers and living near power lines or working in high electric field environments. Alterations in pineal function have been proposed as a mechanism through which power‐frequency MFs may interact with living organisms. A double blind laboratory study was performed to evaluate daytime exposure effects of 100 μT root mean square (rms) 50 Hz MF. Three head exposure sessions of 30 min each were performed: sham, continuous, and intermittent (15 s on/off cycles) MFs were presented to each subject in early or late afternoon (13:30 or 16:30 hr). Twenty‐one healthy male volunteers (20–27 yr old) participated in these 3‐weekly experimental conditions. Blood samples were drawn for serum melatonin measurement, hourly at night (from 20:00 to 07:00 hr) under controlled environmental conditions. Urinary excretion of 6‐sulfatoxymelatonin (aMT6s), the main melatonin metabolite, was measured for a 17 hr period, by means of urine samples taken at 19:00 hr (14:00–19:00 hr “afternoon period”), 23:00 hr (19:00–23:00 hr “evening period”), and 07:00 hr, day 2 (23:00–07:00 hr day 2 “night‐time period”). There were no significant differences in either plasma melatonin or in aMT6s excretion profiles in the three experimental conditions. However, a tendency for a smaller increase of night‐time urinary aMT6s after continuous MF exposure was found (P=0.08) particularly in men with the lower excretion rate of aMT6s (“Low Group”) (P=0.07). We conclude that this study does not indicate that daytime acute MF exposure influences either melatonin secretion or aMT6s excretion. Inter‐individual differences in pineal production of melatonin, however, have to be taken into account in further studies.

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“…Although EMFinduced suppression on nocturnal melatonin secretion has been reported in occupational and residential studies [15,16,17,18,19,20], in the majority of laboratory-based exposure studies [21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39], EMF did not exert a distinct influence on melatonin or 6-hydroxymelatonin concentrations[see 40] (Table 1). According to Karasek et al [28,40], discrepancies in the results may depend on different experimental paradigms, including differences in certain characteristics of the applied magnetic fields, such as field induction, frequency, duration of exposure, timing of exposure, applied vector, etc.…”

Section: Electromagnetic Fields and Melatoninmentioning

confidence: 99%

Electromagnetic Fields and Human Endocrine System

Karasek

Woldańska-Okońska

2004

The Scientific World JOURNAL

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Extremely low frequency electromagnetic fields (ELF EMF) are commonly present in daily life all over the world. Moreover, EMF are used in the physiotherapy of many diseases because of their beneficial effects. There is widespread public concern that EMF may have potential consequences for human health.Although experimental animal studies indicate that EMF may influence secretion of some hormones, the data on the effects of EMF on human endocrine system are scarce. Most of the results concentrate on influence of EMF on secretion of melatonin. In this review, the data on the influence of EMF on human endocrine system are briefly presented and discussed.KEYWORDS: electromagnetic fields, endocrine system, hormones DOMAINS: microscopy, medicine, endocrinology, sport medicine and physiotherapy. INTRODUCTIONExtremely low frequency electromagnetic fields (ELF EMF) are commonly present in daily life all over the world. They are associated with the use of electric power applied in residential and occupational environments. Wherever electricity is generated, transmitted, or used, electric and magnetic fields are created due to the presence of motion of electric charges. They are emitted by power lines, electrical panels, transformers, and service wires, but also by such household appliances as televisions, electric blankets, hair driers, etc. [1]. Moreover, electromagnetic fields (EMF) are used in the physiotherapy of many diseases (e.g., low back pain syndrome, migraine and vasomotoric headaches, multiple sclerosis, degenerative processes of the bones and joints, rheumatoid arthritis) because of their beneficial effects (e.g., improvement of soft tissue regeneration processes, vasodilatory action, acceleration of bone adhesion formation, anti-inflammatory and analgesic action) [2,3].There is widespread public concern that EMF may have potential consequences for human health [1,4,5], especially associated with increased risk for cancer and childhood leukemia [5]. 23 Karasek and Woldanska-Okonska: EMFs and hormones TheScientificWorldJOURNAL (2004) 4(S2), 23-28 Additionally some attention has also been paid to other possible health hazards, such as interference with cardiac pacemakers[6], Alzheimer's disease [7], and adverse pregnancy outcome [8].Although there is still scientific controversy concerning that problem, it seems to be a growing consensus that human health hazard associated with exposure to EMF is either very small or restricted to small subgroups. A Working Group organized by the National Institute of Environmental Health Services concluded in a report published in 1998, on the basis of almost 900 publications, that: "None of the evidence for adverse health effects seen after exposure to ELF EMF achieved a degree of evidence exceeding 'inadequate' (for humans) or 'weak' (for experimental animals)" [1].Studies on the effects of EMF in humans concentrate mainly on power line frequency fields or fields used in mobile phones. The influence of ELF EMF used in physiotherapy on the endocrine system was rarely exa...

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Chronic exposure to 2.9 mT, 40 Hz magnetic field reduces melatonin concentrations in humans

Cited by 36 publications

References 31 publications

Population-Based Case-Control Study of Occupational Exposure to Electromagnetic Fields and Breast Cancer

Population-Based Case-Control Study of Occupational Exposure to Electromagnetic Fields and Breast Cancer

Daytime 50 Hz magnetic field exposure and plasma melatonin and urinary 6‐sulfatoxymelatonin concentration profiles in humans

Electromagnetic Fields and Human Endocrine System

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