Chronic exposure to glucocorticoids induces suboptimal decision-making in mice

Cabeza, Lidia; Ramadan, Bahrie; Giustiniani, Julie; Houdayer, Christophe; Pellequer, Yann; Gabriel, Damien; Fauconnet, Sylvie; Haffen, Emmanuel; Risold, Pierre‐Yves; Fellmann, D; Belin, David; Peterschmitt, Yvan

doi:10.1016/j.euroneuro.2021.01.094

Cited by 14 publications

(21 citation statements)

References 80 publications

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“…Besides, this could also reflect psychomotor deficits reminiscent to those observed in neuropsychiatric conditions in accord with our previous preclinical (Cabeza et al, 2021) and clinical data (Bennabi et al, 2013). Thus, this result adds value to data suggesting that chronic CORT exposure yields mice especially vulnerable to action-outcome encoding and further consolidation in food reward-based tasks, in accord with our previous results on valuebased decision-making under uncertainty (Cabeza et al, 2021).…”

Section: Discussionsupporting

confidence: 90%

“…Modelling distress conditions in animals results, for instance, in disruption of fronto-striatal cognition (Uribe-Mariño et al, 2016; Hupalo et al, 2019) and compromises positive valence systems (Birnie et al, 2020) through alteration of crf signalling. In a previous study we have demonstrated that chronic CORT exposure induces suboptimal decision-making in distressed male mice (Cabeza et al 2021), and we have suggested that this alteration relates to high mPFC CRF levels. Here we demonstrated that chronic CORT also prompts reward and effort processing, and learning deficits in male mice.…”

Section: Discussionmentioning

confidence: 78%

“…The study of positive valence-based motivated behaviours in rodents is valuable for translational research in reinforcement learning, but unfortunately literature is incongruent with regards to findings concerning the CORT model. As chronic CORT administration induces a consistent negative valence phenotype (David et al, 2009a; Dieterich et al, 2019), not all aspects of hedonic appreciation, including reward valuation, are reported altered (Cabeza et al, 2021). Grounded on previous studies showing different consummatory scores in healthy mice displaying different gambling strategies (Pittaras et al, 2016), this study sought for new scientific evidence on distress-induced underappreciation of reward as a modulator of decisional strategies.…”

Section: Discussionmentioning

confidence: 99%

“…The SPT lasted four consecutive nights (one night of forced sucrose consumption and 3 nights of free choice) and was performed as previously described (Cabeza et al, 2021). The sucrose preference was calculated as the percentage of sucrose solution consumption relative to the total liquid intake, during the last session.…”

Section: Methodsmentioning

confidence: 99%

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Chronic distress in male mice impairs motivation compromising both effort and reward processing with altered anterior insular cortex and basolateral amygdala neural activation

Cabeza

Ramadan

Cramoisy

et al. 2021

Preprint

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In humans and mammals, effort-based decision-making for monetary or food rewards paradigms contribute to the study of adaptive goal-directed behaviours acquired through reinforcement learning. Chronic distress modelled by repeated exposure to glucocorticoids in rodents induces suboptimal decision-making under uncertainty by impinging on instrumental acquisition and prompting negative valence behaviours. In order to further disentangle the motivational tenets of adaptive decision-making, this study addressed the consequences of enduring distress on relevant effort and reward processing dimensions. Experimentally, appetitive and consummatory components of motivation were evaluated in adult C57BL/6JRj male mice experiencing chronic distress induced by oral corticosterone (CORT), using multiple complementary discrete behavioural tests. Behavioural data (from Novelty Supressed Feeding, operant effort-based choice, Free Feeding and Sucrose Preference tasks) collectively show that behavioural initiation, effort allocation and hedonic appreciation and valuation are altered in mice exposed to several weeks of oral CORT treatment. Additionally, data analysis from FosB immunohistochemical processing of postmortem brain samples highlight a CORT-dependent dampening of neural activation in the anterior insular cortex (aIC) and basolateral amygdala (BLA), key telencephalic brain regions involved in cue appetitive and consummatory motivational processing. Combined, these results suggest that chronic distress-induced irregular aIC and BLA neural activations with reduced effort production and attenuated reward value processing during reinforcement-based instrumental learning could result in maladaptive decision-making under uncertainty. The current study further illustrates how the stoichiometry of effort and reward processing contributes to dynamically adjust the motivational threshold triggering goal-directed behaviours in versatile environments.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Chronic distress in male mice impairs motivation compromising both effort and reward processing with altered anterior insular cortex and basolateral amygdala neural activation

Cabeza

Ramadan

Cramoisy

et al. 2021

Preprint

Self Cite

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“…Western blot for CRF of dura mater. Tissue lysates were prepared and were analyzed with western blot as previously described 55,56 . Briefly, the collected dura mater was homogenized and centrifuged for 30 min at 12,000 rpm.…”

Section: Mouse Dural Injectionmentioning

confidence: 99%

Mast cell-specific receptor/corticotropin-releasing factor axis regulates alcohol withdrawal-associated headache

Son

Zhang

Shannonhouse

et al. 2021

Preprint

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Rehabilitation from alcohol addiction or abuse is challenging due to alcohol withdrawal symptoms. Headache is a severe alcohol withdrawal symptom that frequently contributes to rehabilitation failure. Despite the need for treating alcohol withdrawal-induced headache, there is no appropriate therapeutic option available. Development of improved therapeutics will depend on obtaining a clearer understanding of alcohol withdrawal-induced headache pain mechanisms. Here, we show that the mast cell-specific receptor MrgprB2 controls development of alcohol withdrawal-induced headache. Withdrawing alcohol from alcohol-acclimated mice induces strong headache behaviors, including facial allodynia, facial pain expressions, and reduced walking movement, symptoms often observed in humans suffering from headache. Observed pain behaviors were abolished in MrgprB2-deficient mice. We observed in vivo spontaneous activation and hypersensitization of trigeminal ganglia neurons in alcohol withdrawal mice, but not in MrgprB2-deficient mice. Corticotropin-releasing factor (CRF) was increased in dura mater after alcohol withdrawal. Injection of CRF into dura mater resulted in activation of trigeminal ganglia neurons and vasodilation, which was accompanied by headache behavior. In cells, CRF evoked Ca2+ transients via MrgprB2 or human MrgprX2. The results indicate that alcohol withdrawal causes headache via mast cell degranulation in dura mater. The process is under control of MrgprB2/MrgprX2, which would appear to represent a potential target for treating alcohol withdrawal-related headache.

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Late acute stress effects on decision-making: The magnified attraction to immediate gains in the iowa gambling task

Molins,

Ben Hassen,

Serrano

2025

Behavioural Brain Research

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Chronic exposure to glucocorticoids induces suboptimal decision-making in mice

Cited by 14 publications

References 80 publications

Chronic distress in male mice impairs motivation compromising both effort and reward processing with altered anterior insular cortex and basolateral amygdala neural activation

Chronic distress in male mice impairs motivation compromising both effort and reward processing with altered anterior insular cortex and basolateral amygdala neural activation

Mast cell-specific receptor/corticotropin-releasing factor axis regulates alcohol withdrawal-associated headache

Late acute stress effects on decision-making: The magnified attraction to immediate gains in the iowa gambling task

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