Chronic exposure to imidacloprid induces inflammation and oxidative stress in the liver &amp; central nervous system of rats

Düzgüner, Vesile; Erdoğan, Suat

doi:10.1016/j.pestbp.2012.06.011

Cited by 146 publications

(97 citation statements)

References 56 publications

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“…Other results of Duzguner and Erdogan [45] have shown an increase in lipid peroxidation, but neither SOD nor CAT activities were affected in the liver of rats following chronic exposure to IMI. An earlier study of Wang et al [46] was observed a significant increase in MDA levels, while the SOD activity was significantly induced and CAT activity was inhibited at most exposure intervals of IMI in earthworm Eisenia fetida.…”

Section: Discussionmentioning

confidence: 60%

Imidacloprid enhances liver damage in Wistar rats: Biochemical, oxidative damage and histological assessment

Chakroun¹,

Grissa²,

Ezzi³

et al. 2017

JCLM

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Section: Discussionmentioning

confidence: 60%

Imidacloprid enhances liver damage in Wistar rats: Biochemical, oxidative damage and histological assessment

Chakroun¹,

Grissa²,

Ezzi³

et al. 2017

JCLM

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“…Human exposure to neonicotinoids is very limited (12.8–350 ng/ml in the urine of farm workers, with or without protection) [28], [29], our study indicated that, at exposure levels, IMI and ACE do not show adverse effects on mouse sperm functions and early embryo development in vitro (data not shown). However, recent animal studies showed that IMI and ACE could cause oxidative stress in body [5], [26], and even chronic exposure of IMI with a low concentration could result in oxidative stress in tissues [30], which warned that low level of neonicotinoid exposure in a long period may also exert impacts on reproduction of human, especially for professional populations.…”

Section: Discussionmentioning

confidence: 99%

Reproductive Effects of Two Neonicotinoid Insecticides on Mouse Sperm Function and Early Embryonic Development In Vitro

Huang

et al. 2013

PLoS ONE

100

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Acetamiprid (ACE) and imidacloprid (IMI) are two major members in the family of neonicotinoid pesticides, which are synthesized with a higher selectivity to insects. The present study determined and compared in vitro effects of ACE, IMI and nicotine on mammalian reproduction by using an integrated testing strategy for reproductive toxicology, which covered sperm quality, sperm penetration into oocytes and preimplantation embryonic development. Direct chemical exposure (500 µM or 5 mM) on spermatozoa during capacitation was performed, and in vitro fertilization (IVF) process, zygotes and 2-cell embryos were respectively incubated with chemical-supplemented medium until blastocyst formation to evaluate the reproductive toxicity of these chemicals and monitor the stages mainly affected. Generally, treatment of 500 µM or 5 mM chemicals for 30 min did not change sperm motility and DNA integrity significantly but the fertilization ability in in vitro fertilization (IVF) process, indicating that IVF process could detect and distinguish subtle effect of spermatozoa exposed to different chemicals. Culture experiment in the presence of chemicals in medium showed that fertilization process and zygotes are adversely affected by direct exposure of chemicals (P<0.05), in an order of nicotine>IMI>ACE, whereas developmental progression of 2-cell stage embryos was similar to controls (P>0.05). These findings unveiled the hazardous effects of neonicotinoid pesticides exposure on mammalian sperm fertilization ability as well as embryonic development, raising the concerns that neonicotinoid pesticides may pose reproductive risks on human reproductive health, especially in professional populations.

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“…Pestisitlerin oluşturduğu serbest oksijen radikalleri, LPO ve birçok oksidatif mekanizmayı uyararak dokuda hasar oluşturur (4,13,36,39). Pestisitlere maruz kalan dokularda, reaktif oksijen türleri antioksidan enzimlere bağlanarak, bu enzimlerin düzeylerinde azalmaya, hatta enzim aktivitelerinde inhibisyona neden olmaktadır (15,40). Cyprinus carpio (sazan balığı), karbamatlı insektisitlerden 50 µg/L karbofuran'a maruz bırakıldıktan 7 ve 30 gün sonra, beyinde MDA düzeyi artmış, karaciğerde ise 30 gün sonra CAT aktivitesi azalmıştır (41).…”

Section: Biyokimyasal Analizlerunclassified

Asetamiprid ve d-Tübokürarin'in Kurbağa Sinir Dokusu Üzerine Etkilerinin İncelenmesi (I: Oksidatif Potansiyel)

Çamlica¹,

Bediz²,

Yalın³

2016

Marmara Pharmaceutical Journal

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Chronic exposure to imidacloprid induces inflammation and oxidative stress in the liver & central nervous system of rats

Cited by 146 publications

References 56 publications

Imidacloprid enhances liver damage in Wistar rats: Biochemical, oxidative damage and histological assessment

Imidacloprid enhances liver damage in Wistar rats: Biochemical, oxidative damage and histological assessment

Reproductive Effects of Two Neonicotinoid Insecticides on Mouse Sperm Function and Early Embryonic Development In Vitro

Asetamiprid ve d-Tübokürarin'in Kurbağa Sinir Dokusu Üzerine Etkilerinin İncelenmesi (I: Oksidatif Potansiyel)

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