Chronic exposure to lead and cadmium pollution results in genomic instability in a model biomonitor species (Apodemus flavicollis Melchior, 1834)

Mitkovska, Vesela; Dimitrov, Hristo; Chassovnikarova, Tsenka

doi:10.1016/j.ecoenv.2020.110413

Cited by 11 publications

(1 citation statement)

References 67 publications

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“…However, heavy metal pollution can greatly affect microorganism morphology and cellular metabolism, leading to a decrease in biodiversity and Pb and Cd [11,12]. Cd was classified as a class I carcinogen by the International Agency for Research on Cancer [29]. The World Health Organization has listed Pb and Cd among the 10 most harmful toxic substances to human health, ranking them second and seventh, respectively [12,30].…”

Section: Introductionmentioning

confidence: 99%

Effects of Multiple-Metal-Compound Contamination on the Soil Microbial Community in Typical Karst Tea Plantations

Huang,

Wang,

et al. 2023

Forests

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In this study, the effects of pollution levels and heavy metal pollution on soil microbial diversity in karst tea plantations are reported. Four tea plantations from plateau hills, under forests, by lakesides and on steep slopes in the South China karst were used as research regions. Soil samples were taken from these tea plantations, the soil heavy metals Cd, Cr, Pb, Zn, Ni and Cu were tested using inductively coupled plasma-mass spectrometry, and Hg and As were tested via atomic fluorescence spectrometry. The soil microbes were analyzed via high-throughput sequencing technology. Heavy metal pollution was evaluated via the single factor index and pollution load index, and the correlation between soil heavy metals and the microbial community was analyzed via SPSS 18.0 and Canoco 5.0 software. The results showed that the studied tea plantation soils were greatly polluted by the heavy metals, Cd and Hg, to a low to moderate degree. The comprehensive pollution of multiple heavy metals occurred only in lakeside tea plantations, in which pollution reached a low degree. It is also suggested that Hg and Cd were the major contributors, followed by Cu. The soil microbial diversity in soil samples from lakeside tea plantations was the highest; however, the discrepancy in its dominant species composition was also the highest. When the pollution load index was close to 0.6, the microbial diversity decreased sharply. Afterward, the diversity and heterogeneity generally gently increased, and the dominant composition was more obvious. These results reveal that the impact of heavy metal pollution on soil microbial diversity was not very distinct, but the impact on the dominant microbial community composition was obvious. In addition, the heavy metals, Cd, Hg and Cu, were the key factors that impacted the soil microbial community composition.

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Section: Introductionmentioning

confidence: 99%

Effects of Multiple-Metal-Compound Contamination on the Soil Microbial Community in Typical Karst Tea Plantations

Huang,

Wang,

et al. 2023

Forests

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How Divalent Cations Interact with the Internal Channel Site of Guanine Quadruplexes

et al. 2021

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The formation of guanine quadruplexes (GQ) in DNA is crucial in telomere homeostasis and regulation of gene expression. Pollution metals can interfere with these DNA superstructures upon coordination. In this work, we study the affinity of the internal GQ channel site towards alkaline earth metal (Mg2+, Ca2+, Sr2+, and Ba2+), and (post‐)transition metal (Zn2+, Cd2+, Hg2+, and Pb2+) cations using density functional theory computations. We find that divalent cations generally bind to the GQ cavity with a higher affinity than conventional monovalent cations (e. g. K+). Importantly, we establish the nature of the cation‐GQ interaction and highlight the relationship between ionic and nuclear charge, and the electrostatic and covalent interactions. The covalent interaction strength plays an important role in the cation affinity and can be traced back to the relative stabilization of cations’ unoccupied atomic orbitals. Overall, our findings contribute to a deeper understanding of how pollution metals could induce genomic instability.

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How Divalent Cations Interact with the Internal Channel Site of Guanine Quadruplexes

et al. 2021

View full text Add to dashboard Cite

The formation of guanine quadruplexes (GQ) in DNA is crucial in telomere homeostasis and regulation of gene expression. Pollution metals can interfere with these DNA superstructures upon coordination. In this work, we study the affinity of the internal GQ channel site towards alkaline earth metal (Mg 2 + , Ca 2 + , Sr 2 + , and Ba 2 + ), and (post-)transition metal (Zn 2 + , Cd 2 + , Hg 2 + , and Pb 2 + ) cations using density functional theory computations. We find that divalent cations generally bind to the GQ cavity with a higher affinity than conventional monovalent cations (e. g. K + ). Importantly, we establish the nature of the cation-GQ interaction and highlight the relationship between ionic and nuclear charge, and the electrostatic and covalent interactions. The covalent interaction strength plays an important role in the cation affinity and can be traced back to the relative stabilization of cations' unoccupied atomic orbitals. Overall, our findings contribute to a deeper understanding of how pollution metals could induce genomic instability.

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Chronic exposure to lead and cadmium pollution results in genomic instability in a model biomonitor species (Apodemus flavicollis Melchior, 1834)

Cited by 11 publications

References 67 publications

Effects of Multiple-Metal-Compound Contamination on the Soil Microbial Community in Typical Karst Tea Plantations

Effects of Multiple-Metal-Compound Contamination on the Soil Microbial Community in Typical Karst Tea Plantations

How Divalent Cations Interact with the Internal Channel Site of Guanine Quadruplexes

How Divalent Cations Interact with the Internal Channel Site of Guanine Quadruplexes

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