Chronic exposure to tetracyclines and subsequent diagnosis for non‐melanoma skin cancer in a large Midwestern U.S. patient population

Vakharia, Paras P.; Nardone, Beatrice; Schlosser, Bethanee J.; Lee, D.; Serrano, Linda; West, Dennis P.

doi:10.1111/jdv.14399

Cited by 8 publications

(4 citation statements)

References 10 publications

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“…Lastly, the causal link between some risk factors and NMSC has been debated. Some evidence suggests a possible increased risk of NMSC in patients that are chronically exposed to certain photoreactive medications such as tetracycline, although further studies are needed to investigate these relationships [ 56 ]. Additionally, there are reported cases of NMSC occurring in the tattooed areas of the skin, but direct association between tattoos and skin cancers has not been established.…”

Section: Brief Overview Of Etiology Risk Factors and Stagingmentioning

confidence: 99%

Updates on the Management of Non-Melanoma Skin Cancer (NMSC)

et al. 2017

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Non-melanoma skin cancers (NMSCs) are the most common malignancy worldwide, of which 99% are basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of skin. NMSCs are generally considered a curable diseases, yet they currently pose an increasing global healthcare problem due to rising incidence. This has led to a shift in emphasis on prevention of NMSCs with development of various skin cancer prevention programs worldwide. This article aims to summarize the most recent changes and advances made in NMSC management with a focus on prevention, screening, diagnosis, and staging.

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Section: Brief Overview Of Etiology Risk Factors and Stagingmentioning

confidence: 99%

Updates on the Management of Non-Melanoma Skin Cancer (NMSC)

et al. 2017

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“…The pathogenesis of ESCC is not clarified and is currently a matter of debate [18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

“…The patient immune system must also be taken into account. Immunodeficiency induced by drugs or other diseases, such as hematologic disorders, may explain the propensity for the development of cancer, inducing a generalized 'field of cancerization' that can induce a Koebner phenomenon and the development of new cutaneous cancers in the site of surgery [17,[21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Eruptive non-melanoma skin cancers/squamous atypia following skin surgery. Report of two new cases, concise review of the literature with special emphasis on treatment options

Chessa

Picciola

Filippi

et al. 2022

Dermatol Pract Concept

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Multiple eruptive cutaneous non-melanoma skin cancers(NMSCs) have been reported to arise at the sites of skin surgery, including the area affected by the primary tumour and split thickness skin graft(STSG) donor and recipient sites. The aim of this study is to make a critical revision of the literature, analysing the clinical, histological features and outcomes of eruptive NMSCs after cutaneous surgery. Up to August 2021, according to our systematic review of the literature, we have collected 18 published articles and a total of 33 patients, including our two cases. The results of this review highlight five red flags that clinicians should consider: (i) lower and upper limbs represent the cutaneous site with the highest risk, representing 82.35% of the cases in the literature; (ii) the median time to onset of eruptive NMSCs that is approximately 6 weeks; (iii) primary NMSCs were completely excised with free margins on histologic examination in all cases of the literature, and therefore the eruptive NMSCs reported could not be considered recurrences; (iv) any surgical technique involves a risk to promote eruptive NMSCs; (v) treatment of eruptive NMSCs includes surgery or combined surgical and medical treatment. However, eruptive NMSCs recurrences are a real medical challenge and have always been treated combining surgical and medical treatment, with complete resolution in about one third of patients. In conclusion, even though the pathogenesis remains unclear, this review highlights 5 red flags which could support clinicians in the diagnosis and management of eruptive of NMSCs after skin surgery.

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“…2,3 Whilst phototoxicity is an attractive hypothesis, TCN, as noted also by the authors, do possess anti-inflammatory properties. 1 An excellent review on doxycycline was recently published, 4 highlighting its immunomodulating properties as well as those of tetracycline, including TNF-a inhibition. In the light of TNF-a and other anti-inflammatory effects of TCN, 1,4 might it not be possible that immunomodulating (immunosuppressive?)…”

mentioning

confidence: 99%