Chronic exposure to UV-aged microplastics induces neurotoxicity by affecting dopamine, glutamate, and serotonin neurotransmission in Caenorhabditis elegans

Chen, Haibo; Hua, Xin; Yang, Yue; Wang, Chen; Jin, Lide; Dong, Chenyin; Chang, Zhaofeng; Ding, Ping; Xiang, Ming; Li, Hui; Yu, Yunjiang

doi:10.1016/j.jhazmat.2021.126482

Cited by 72 publications

(22 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, adult zebrafish exposed to tetrabromobisphenol had a significantly decreased serotonin content, and overt neurotoxicity was evident in the larval offspring . Similarly, exposure to UV-aged microplastics leads to neurotoxicity in Caenorhabditis elegans by modulating glutamate, serotonin, and dopamine levels …”

Section: Resultsmentioning

confidence: 99%

“…53 Similarly, exposure to UV-aged microplastics leads to neurotoxicity in Caenorhabditis elegans by modulating glutamate, serotonin, and dopamine levels. 54 Alterations of neurotransmitter levels in the brain have a range of impacts on biotic physiology and behavior. For example, DOPAC is a metabolite of the neurotransmitter dopamine, is a sensitive indicator of neuronal function, and can be used as an indicator of central nervous system (CNS) disorders.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Polystyrene Nanoplastics Toxicity to Zebrafish: Dysregulation of the Brain–Intestine–Microbiota Axis

et al. 2022

Self Cite

View full text Add to dashboard Cite

In animal species, the brain–gut axis is a complex bidirectional network between the gastrointestinal (GI) tract and the central nervous system (CNS) consisting of numerous microbial, immune, neuronal, and hormonal pathways that profoundly impact organism development and health. Although nanoplastics (NPs) have been shown to cause intestinal and neural toxicity in fish, the role of the neurotransmitter and intestinal microbiota interactions in the underlying mechanism of toxicity, particularly at environmentally relevant contaminant concentrations, remains unknown. Here, the effect of 44 nm polystyrene nanoplastics (PS-NPs) on the brain–intestine–microbe axis and embryo–larval development in zebrafish (Danio rerio) was investigated. Exposure to 1, 10, and 100 μg/L PS-NPs for 30 days inhibited growth and adversely affected inflammatory responses and intestinal permeability. Targeted metabolomics analysis revealed an alteration of 42 metabolites involved in neurotransmission. The content of 3,4-dihydroxyphenylacetic acid (DOPAC; dopamine metabolite formed by monoamine oxidase activity) was significantly decreased in a dose-dependent manner after PS-NP exposure. Changes in the 14 metabolites correlated with changes to 3 microbial groups, including Proteobacteria, Firmicutes, and Bacteroidetes, as compared to the control group. A significant relationship between Firmicutes and homovanillic acid (0.466, Pearson correlation coefficient) was evident. Eight altered metabolites (l-glutamine (Gln), 5-hydroxyindoleacetic acid (5-HIAA), serotonin, 5-hydroxytryptophan (5-HTP), l-cysteine (Cys), l-glutamic acid (Glu), norepinephrine (NE), and l-tryptophan (l-Trp)) had a negative relationship with Proteobacteria although histamine (His) and acetylcholine chloride (ACh chloride) levels were positively correlated with Proteobacteria. An Associated Network analysis showed that Firmicutes and Bacteroidetes were highly correlated (0.969). Furthermore, PS-NPs accumulated in the gastrointestinal tract of offspring and impaired development of F1 (2 h post-fertilization) embryos, including reduced spontaneous movements, hatching rate, and length. This demonstration of transgenerational deficits is of particular concern. These findings suggest that PS-NPs cause intestinal inflammation, growth inhibition, and restricted development of zebrafish, which are strongly linked to the disrupted regulation within the brain–intestine–microbiota axis. Our study provides insights into how xenobiotics can disrupt the regulation of brain–intestine–microbiota and suggests that these end points should be taken into account when assessing environmental health risks of PS-NPs to aquatic organisms.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Polystyrene Nanoplastics Toxicity to Zebrafish: Dysregulation of the Brain–Intestine–Microbiota Axis

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…This was also associated with decreased mitochondria function and increased oxidative stress ( Liu et al, 2020c ), suggesting dopaminergic specific toxicity upon PS-MP exposure. The exposure to UV-aged PS-MPs caused more severe dopaminergic defects than virgin MPs, probably due to the leaching of toxic materials ( Chen et al, 2021a ). Interestingly, PS-NP exposure in C. elegans causes significant increase in the expression level of intestinal dop-1 , a gene encoding for a dopamine receptor ( Qu et al, 2020a ), further supporting the idea of MP-driven interference with the dopaminergic system in nematodes.…”

Section: The Effects Of Microplastics and Nanoplastics On Reproductiv...mentioning

confidence: 99%

Microplastics and Their Impact on Reproduction—Can we Learn From the C. elegans Model?

et al. 2022

View full text Add to dashboard Cite

Biologically active environmental pollutants have significant impact on ecosystems, wildlife, and human health. Microplastic (MP) and nanoplastic (NP) particles are pollutants that are present in the terrestrial and aquatic ecosystems at virtually every level of the food chain. Moreover, recently, airborne microplastic particles have been shown to reach and potentially damage respiratory systems. Microplastics and nanoplastics have been shown to cause increased oxidative stress, inflammation, altered metabolism leading to cellular damage, which ultimately affects tissue and organismal homeostasis in numerous animal species and human cells. However, the full impact of these plastic particles on living organisms is not completely understood. The ability of MPs/NPs to carry contaminants, toxic chemicals, pesticides, and bioactive compounds, such as endocrine disrupting chemicals, present an additional risk to animal and human health. This review will discusses the current knowledge on pathways by which microplastic and nanoplastic particles impact reproduction and reproductive behaviors from the level of the whole organism down to plastics-induced cellular defects, while also identifying gaps in current knowledge regarding mechanisms of action. Furthermore, we suggest that the nematode Caenorhabditis elegans provides an advantageous high-throughput model system for determining the effect of plastic particles on animal reproduction, using reproductive behavioral end points and cellular readouts.

show abstract

“…Nevertheless, MPs exposed to ultraviolet radiation for a long time have a stronger toxic effect on organisms. Compared with raw PS-MPs, long-term exposure to photoaged PS-MPs solution at low concentration (1 μg/L) resulted in stronger neurotoxicity to nematodes, which is due to the neurotoxicity of aged PS-MPs by affecting the neurotransmission of dopamine, glutamate and serotonin [ 90 ]. The photoaged PP and PS further reduced the enzyme activity of the microorganisms in the soil, so the photoaged MPs would more significantly affect the environmental function of the soil [ 91 ].…”

Section: Environmental Risks Of Mps After Photoagingmentioning

confidence: 99%

Non-Negligible Effects of UV Irradiation on Transformation and Environmental Risks of Microplastics in the Water Environment

Cheng

Zhang

Liu

et al. 2021

JoX

View full text Add to dashboard Cite

Microplastics (MPs) are ubiquitous in environmental media, and their harmful effects on MPs on the ecosystem have attracted more and more attention. Once released into the environment, MPs can trigger oxidative degradation through ultraviolet (UV) to cause photoaging. Photoaging significantly affects the properties of MPs, which leads to changing their environmental behaviors and increasing environmental risks. In this review, the generation of MPs under UV irradiation and the influence of environmental factors on the photoaging of MPs were discussed. Photoaging of MPs is an important process affecting the migration, transformation and interaction of pollutants in water and soil. In order to fully predict the fate and environmental interaction of MPs, more researches are needed in the future to explore the photoaging behavior of different types of MPs under natural environmental conditions.

show abstract

Chronic exposure to UV-aged microplastics induces neurotoxicity by affecting dopamine, glutamate, and serotonin neurotransmission in Caenorhabditis elegans

Cited by 72 publications

References 57 publications

Polystyrene Nanoplastics Toxicity to Zebrafish: Dysregulation of the Brain–Intestine–Microbiota Axis

Polystyrene Nanoplastics Toxicity to Zebrafish: Dysregulation of the Brain–Intestine–Microbiota Axis

Microplastics and Their Impact on Reproduction—Can we Learn From the C. elegans Model?

Non-Negligible Effects of UV Irradiation on Transformation and Environmental Risks of Microplastics in the Water Environment

Contact Info

Product

Resources

About