Chronic Familial Hyperbilirubinemia

Coinheritance of Rotor Syndrome, G‐6‐PD Deficiency, and Heterozygous β Thalassemia: A Possible Genetic Interaction

“…The coinheritance of Rotor syndrome with potentially hemolytic disorders could explain the tendency to develop more pronounced bilirubinemia earlier in life. Indeed, in one patient with Rotor syndrome and in three of his children, two of whom also had hyperbilirubinemia and elevated bromosulfophthalein retention, occult hemolysis resulting from shortened red blood cell life spans have been described, although not attributed to a recognized inherited disorder (16). Moreover, Harada et al (17) described three brothers with G‐6‐PD deficiency, hemolysis, moderately prolonged bromosulfophthalein retention, mild transaminase abnormalities, and elevated direct bilirubin component.…”