Chronic Familial Mediterranean Fever with Development of Secondary Amyloidosis

Abstract

A 20-year-old Turkish male presented with fever, abdominal pain, and systemic lethargy. His clinical history revealed symptoms to be self-limiting but reoccurring over the past six months. Blood and urine specimens collected indicated renal amyloidosis. A kidney CT image indicated kidney inflammation. He was diagnosed with Familial Mediterranean Fever with the development of secondary amyloidosis and treated with colchicine.

Secondary (AA) Amyloidosis with Development of Nephrotic Syndrome

“…Plasma fibrinogen facilitates erythrocyte aggregation; this increases blood viscosity and elevates ESR. 19 Chemistry tests also indicated decreased serum albumin and increased creatinine. Because the patient's kidneys were damaged, large amounts of albumin protein escaped the blood and entered into the urine, this explains why the patient had on August 5 2020 http://hwmaint.clsjournal.ascls.org/ Downloaded from proteinuria.…”

“…7 These illnesses included arthritis, Crohn's disease, ankylosing spondylitis, Familial Mediterranean Fever, chronic infections and certain types of cancer. 7,19 Treatments tailored to the individual disease included biologics like anti-TNF drugs, anti-IL-1 drugs, corticosteroids, colchicine and antibiotics. 7,19 With better management of the known underlining inflammatory conditions, fewer cases of secondary amyloidosis developed, and for those with the disease, prognosis was improved.…”