Chronic fatigue: an evolutionary concept analysis

Jorgensen, Roberta A.

doi:10.1111/j.1365-2648.2008.04649.x

Cited by 58 publications

(37 citation statements)

References 70 publications

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“…The term fatigue has been used consistently in the literature to describe a state of tiredness that is clinically significant and pathological in nature [1]. It is usually defined as a condition of feeling very tired, weary or sleepy resulting from insufficient sleep, prolonged mental or physical work, extended periods of stress or anxiety.…”

Section: Introductionmentioning

confidence: 99%

Portuguese version of the Swedish Occupational Fatigue Inventory (SOFI) among assembly workers: Cultural adaptation, reliability and validity

Baptista

Carvalhais

Ramos

et al. 2017

Int J Occup Med Environ Health

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Objectives: Reliable and valid instruments are essential for understanding fatigue in occupational settings. This study analyzed the psychometric properties of the Portuguese version of the Swedish Occupational Fatigue Inventory (SOFI). Material and Methods: A cross-sectional study was conducted with 218 workers from an automotive industry involved in assembly tasks for fabrication of mechanical cables. Convergent and discriminant validity, internal consistency reliability and confirmatory factor analysis were performed. Results: Results showed adequate fit to data, yielding a 20-item, 5-factor structure (all intercorrelated): Chi 2 /df (ratio Chi 2 and degrees of freedom) = 2.530, confirmatory fit index (CFI) = 0.919, goodness of fit index (GFI) = 0.845, root mean square error of approximation (RMSEA) = 0.084. The SOFI presented an adequate internal consistency, with the sub-scales and total scale presenting good reliability values (Cronbach's α values from 0.742 to 0.903 and 0.943 respectively). Conclusions: Findings suggest that the Portuguese version of the SOFI may be a useful tool to assess fatigue and prevent work-related injuries. In future research, other instruments should be used as an external criterion to correlate with the SOFI dimensions. Int J Occup Med Environ Health 2017;30(3):407-417

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Section: Introductionmentioning

confidence: 99%

Portuguese version of the Swedish Occupational Fatigue Inventory (SOFI) among assembly workers: Cultural adaptation, reliability and validity

Baptista

Carvalhais

Ramos

et al. 2017

Int J Occup Med Environ Health

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“…For this reason, there is no standard treatment for chronic fatigue [4] and some patients with chronic fatigue, therefore, turn to complementary and alternative medicine (CAM) for treatment [5, 6]. In East Asian countries, CAM in the form of traditional herbal medicine is widely used to treat fatigue [7, 8]; the traditional herbal drug, Gongjin - dan (GJD), is generally prescribed by Korean traditional medicine physicians to treat patients with chronic fatigue in Korean traditional medicine clinics.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the anti-fatigue effects of a traditional herbal drug, Gongjin-dan, under insufficient sleep conditions: study protocol for a randomised controlled trial

Son

Kim

et al. 2016

Trials

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BackgroundMany herbal medicines are traditionally used as anti-fatigue agents in east Asian countries; however, there is a dearth of clinical evidence supporting the anti-fatigue effects of such medicines and their mechanisms. This study is a feasibility trial to assess the clinical efficacy of Gongjin-dan (GJD) and verify its mechanisms by exploring fatigue outcomes, including endocrine and immunological biomarkers in humans.Methods/DesignTo investigate the anti-fatigue effects of GJD and the mechanism underlying these effects, a randomised, double-blind, placebo-controlled crossover clinical trial was designed. Participants (24 healthy male volunteers) will be hospitalised for 4 days (3 nights), during which acute fatigue and stress conditions will be induced by sleep deprivation, and GJD or a placebo will be administered (twice daily). The primary outcome will be changes in serum cortisol levels, measured in the morning, as an objective biomarker of sleep deprivation-induced fatigue and stress. The secondary outcomes will include: the Fatigue Severity Scale; the Brief Fatigue Inventory, and the Leeds Sleep Evaluation Questionnaire scores; levels of salivary cortisol, epinephrine, norepinephrine, oxidative stress-related biomarkers, homocysteine, and immunological factors; and heart rate variability. After a washout period of more than 4 weeks, a second treatment phase will commence in which participants who were previously administered the placebo will receive the drug and vice versa, following the same treatment regime as in the first phase.DiscussionThis study protocol provides a unique opportunity to enhance our understanding of fatigue and the effects of GJD on fatigue in terms of endocrine and immunological mechanisms by validating the study design and determining feasibility. Findings from this trial will help researchers to design a pilot or definitive clinical trial of traditional herbal medicine for chronic fatigue.Trial registrationKorean National Clinical Trial Registry CRIS; KCT0001681, registered on 29 October 2015.

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“…Patients with chronic fatigue are faced with a pathogenic status regarding physical, social, and occupational well-being. 1 In particular, medically unexplained chronic fatigue, idiopathic chronic fatigue (ICF), and chronic fatigue syndrome (CFS) are agonizing illnesses due to severe impairment of quality of life and lack of effective therapies. 2 Thus, patients suffering from ICF or CFS frequently use alternative and complementary therapies.…”

Section: Introductionmentioning

confidence: 99%

Indirect Moxibustion (CV4 and CV8) Ameliorates Chronic Fatigue: A Randomized, Double-Blind, Controlled Study

Kim

Yoo

Park

et al. 2013

The Journal of Alternative and Complementary Medicine

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Objectives: The antifatigue effect of indirect moxibustion and its antioxidant properties were investigated. Subjects and design: A randomized, double-blind, controlled clinical trial was performed with 44 patients who had idiopathic chronic fatigue. The subjects were treated with a placebo or moxibustion (indirect moxibustion on CV4 and CV8 3 times per week for 4 weeks), and their fatigue severity was monitored using a self-rating numeric scale (NRS) and a visual analog scale (VAS). Serum level of reactive oxygen species and malondialdehyde (MDA), total antioxidant capacity, the activity of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase and total glutathione content, were determined before initial moxibustion therapy and after the 12th moxibustion treatment. Results: The moxibustion group had a significantly lower fatigue severity score compared to the control for both the NRS ( p < 0.05) and VAS scores ( p < 0.01). The level of serum MDA was significantly lower in the moxibustion group than in the placebo group ( p < 0.05), whereas glutathione reductase activity and total glutathione content increased significantly following moxibustion ( p < 0.05). Conclusions:The results provide clinical evidence for an antifatigue effect of indirect moxibustion at CV4 and CV8 and suggest that the effect is due to the antioxidant properties of moxibustion.

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Chronic fatigue: an evolutionary concept analysis

Abstract: Further research is needed to identify the aetiology of chronic fatigue and to address the social context of living with this disabling symptom.

Cited by 58 publications

References 70 publications

Portuguese version of the Swedish Occupational Fatigue Inventory (SOFI) among assembly workers: Cultural adaptation, reliability and validity

Portuguese version of the Swedish Occupational Fatigue Inventory (SOFI) among assembly workers: Cultural adaptation, reliability and validity

Evaluation of the anti-fatigue effects of a traditional herbal drug, Gongjin-dan, under insufficient sleep conditions: study protocol for a randomised controlled trial

Indirect Moxibustion (CV4 and CV8) Ameliorates Chronic Fatigue: A Randomized, Double-Blind, Controlled Study

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