Chronic fatigue syndrome and multiple sclerosis have reduced craniospinal compliance and dilated pressurized bridging cortical veins

Bateman, Grant A; Bateman, Alexander R

doi:10.1016/j.mehy.2023.111243

Cited by 1 publication

(1 citation statement)

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“…It has been suggested the reason fatigued individuals, such as those with chronic fatigue syndrome, complain of non-restorative sleep is both that the refreshing part of nonrapid eye movement sleep is altered, with a decrease in parasympathetic activity 71 and the glymphatic clearance system is impaired 72 . Indeed, in chronic fatigue syndrome/ myalgic encephalitis, there is also anecdotal evidence of venous outflow dilatation, which could impair glymphatic outflow 73 . In space missions, there is a reduction in sleep time, reduced slow-wave sleep and changes in the architecture of the sleep 74 .…”

Section: Similarities Between Sans and Syringomyeliamentioning

confidence: 99%

A perspective on the evidence for glymphatic obstruction in spaceflight associated neuro-ocular syndrome and fatigue

Bateman,

Bateman

2024

npj Microgravity

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Spaceflight associated neuro-ocular syndrome (SANS) alters the vision of astronauts during long-duration spaceflights. Previously, the current authors have discussed the similarities and differences between SANS and idiopathic intracranial hypertension to try to elucidate a possible pathophysiology. Recently, a theory has been advanced that SANS may occur secondary to failure of the glymphatic system caused by venous dilatation within the brain and optic nerves. There is recent evidence to suggest glymphatic obstruction occurs in childhood hydrocephalus, multiple sclerosis and syringomyelia due to venous outflow dilatation similar to that proposed in SANS. The purpose of the current paper is to discuss the similarities and differences between the known CSF and venous pathophysiology in SANS with these other terrestrial diseases, to see if they can shed any further light on the underlying cause of this microgravity-induced disease.

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