Chronic Fatigue Syndrome and the Central Nervous System

Chen, R; Liang, FX; Moriya, Junji; Yamakawa, J; Sumino, Hiroyuki; Kanda, Tsugiyasu; Takahashi, Takashi

doi:10.1177/147323000803600501

Cited by 48 publications

(42 citation statements)

References 45 publications

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“…Although, at least numerically, performance declined more for patients than controls across the three test runs 3 , there was no interaction between factors.…”

Section: Smooth Pursuitmentioning

confidence: 79%

“…ME/CFS affects many individuals and its prevalence has been estimated to be between 0.2 and 0.4% of the population [1]. The illness also has widespread physiological impact and has been shown to affect the immune system [2] , the central nervous system [3] , and the cardiovascular system [4]. 1 There are a variety of case definitions for ME/CFS [7] and the most widely used for research is the 1994 Center for Disease Control and Prevention (CDC) definition [8].…”

Section: Introductionmentioning

confidence: 99%

“…This would correspond to motor disturbances in ME/CFS reported by [5] and ME/CFS related central nervous system dysfunction cf. [3]. Establishing the characteristics of eye movement problems in ME/CFS is therefore important because doing so may: (1) provide further understanding of the symptoms related to ME/CFS; (2) provide insights into pathophysiological impacts of the condition and (3) provide an objective measure that could be used in its diagnosis and, in particular, provide a means by which it may be distinguished from other conditions.…”

Section: Introductionmentioning

confidence: 99%

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Characterising eye movement dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome

Badham

Hutchinson

2013

Graefes Arch Clin Exp Ophthalmol

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Background People who suffer from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) often report that their eye movements are sluggish and that they have difficulties tracking moving objects. However, descriptions of these visual problems are based solely on patients' self-reports of their subjective visual experiences and there is a distinct lack of empirical evidence to objectively verify their claims. This paper presents the first experimental research to objectively examine eye movements in those suffering from ME/CFS.Methods Patients were assessed for ME/CFS symptoms and were compared to age, gender and education matched controls for their ability to generate saccades and smooth pursuit eye movements.Results Patients and controls exhibited similar error rates and saccade latencies (response times) on prosaccade and antisaccade tasks. Patients showed relatively intact ability to accurately fixate the target (prosaccades) but were impaired when required to focus accurately in a specific position opposite the target (antisaccades). Patients were most markedly impaired when required to direct their gaze as closely as possible to a smoothly moving target (smooth pursuit).Conclusions It is hypothesised that the effects of ME/CFS can be overcome briefly for completion of saccades, but that continuous pursuit activity (accurately tracking a moving object) even for a short time period highlights dysfunctional eye movement behaviour in ME/CFS patients. Future smooth pursuit research may elucidate and improve diagnosis of ME/CFS.

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“…Although, at least numerically, performance declined more for patients than controls across the three test runs 3 , there was no interaction between factors.…”

Section: Smooth Pursuitmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterising eye movement dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome

Badham

Hutchinson

2013

Graefes Arch Clin Exp Ophthalmol

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“…In ME/CFS brain activity is significantly more diffuse (Chen et al 2008), possibly as a compensation mechanism (Lange et al 2005).…”

mentioning

confidence: 99%

“…Moreover, a correlation between neurological abnormalities and neurocognitive functioning has been established (Lange et al 2005 ;Chen et al 2008).…”

mentioning

confidence: 99%

Letter to the Editor: Plausible explanations for neurocognitive deficits in ME/CFS, aggravation of neurocognitive impairment induced by exertion

Twisk¹,

Arnoldus²,

Maes³

2010

Psychol. Med.

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Volumetric differences in hippocampal subfields and associations with clinical measures in myalgic encephalomyelitis/chronic fatigue syndrome

Thapaliya

Staines

Marshall‐Gradisnik

et al. 2022

J of Neuroscience Research

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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients suffer from a cognitive and memory dysfunction. Because the hippocampus plays a key role in both cognition and memory, we tested for volumetric differences in the subfields of the hippocampus in ME/CFS. We estimated hippocampal subfield volumes for 25 ME/CFS patients who met Fukuda criteria only (ME/CFS Fukuda ), 18 ME/CFS patients who met the stricter ICC criteria (ME/CFS ICC ), and 25 healthy controls (HC). Group comparisons with HC detected extensive differences in subfield volumes in ME/CFS ICC but not in ME/ CFS Fukuda . ME/CFS ICC patients had significantly larger volume in the left subiculum head (p < 0.001), left presubiculum head (p = 0.0020), and left fimbria (p = 0.004). Correlations of hippocampus subfield volumes with clinical measures were stronger in ME/CFS ICC than in ME/CFS Fukuda patients. In ME/CFS Fukuda patients, we detected positive correlations between fatigue and hippocampus subfield volumes and a negative correlation between sleep disturbance score and the right CA1 body volume. In ME/CFS ICC patients, we detected a strong negative relationship between fatigue and left hippocampus tail volume.Strong negative relationships were also detected between pain and SF36 physical scores and two hippocampal subfield volumes (left: GC-ML-DG head and CA4 head). Our study demonstrated that volumetric differences in hippocampal subfields have strong statistical inference for patients meeting the ME/CFS ICC case definition and confirms hippocampal involvement in the cognitive and memory problems of ME/CFS ICC patients.

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Chronic Fatigue Syndrome and the Central Nervous System

Cited by 48 publications

References 45 publications

Characterising eye movement dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome

Characterising eye movement dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome

Letter to the Editor: Plausible explanations for neurocognitive deficits in ME/CFS, aggravation of neurocognitive impairment induced by exertion

Volumetric differences in hippocampal subfields and associations with clinical measures in myalgic encephalomyelitis/chronic fatigue syndrome

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