Chronic Fatigue Syndrome at Age 16 Years

Collin, Simon M.; Norris, Tom; Nuevo, Roberto; Tilling, Kate; Joinson, Carol; Sterne, Jonathan A C; Crawley, Esther

doi:10.1542/peds.2015-3434

Cited by 33 publications

(38 citation statements)

References 43 publications

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“…Age 16 years: Our method for defining CFS at age 16 years has been described previously 15. Briefly, a classification of CFS/ME was based on both parental and child-reported data.…”

Section: Methodsmentioning

confidence: 99%

Obesity in adolescents with chronic fatigue syndrome: an observational study

et al. 2016

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ObjectiveIdentify the prevalence of obesity in patients with chronic fatigue syndrome (CFS) compared with healthy adolescents, and those identified with CFS in a population cohort.DesignCross-sectional analysis of multiple imputed data.SettingData from UK paediatric CFS/myalgic encephalomyelitis (CFS/ME) services compared with data collected at two time points in the Avon Longitudinal Study of Parents and Children (ALSPAC).Patients1685 adolescents who attended a CFS/ME specialist service between 2004 and 2014 and 13 978 adolescents aged approximately 13 years and 16 years participating in the ALSPAC study.Main outcome measuresBody mass index (BMI) (kg/m2), sex-specific and age-specific BMI Z-scores (relative to the International Obesity Task Force cut-offs) and prevalence of obesity (%).ResultsAdolescents who had attended specialist CFS/ME services had a higher prevalence of obesity (age 13 years: 9.28%; age 16 years: 16.43%) compared with both adolescents classified as CFS/ME in ALSPAC (age 13 years: 3.72%; age 16 years: 5.46%) and those non-CFS in ALSPAC (age 13 years: 4.18%; age 16 years: 4.46%). The increased odds of obesity in those who attended specialist services (relative to non-CFS in ALSPAC) was apparent at both 13 years (OR: 2.31 (1.54 to 3.48)) and 16 years, with a greater likelihood observed at 16 years (OR: 4.07 (2.04 to 8.11)).ConclusionsWe observed an increased prevalence of obesity in adolescents who were affected severely enough to be referred to a specialist CFS/ME service. Further longitudinal research is required in order to identify the temporal relationship between the two conditions.

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“…Age 16 years: Our method for defining CFS at age 16 years has been described previously 15. Briefly, a classification of CFS/ME was based on both parental and child-reported data.…”

Section: Methodsmentioning

confidence: 99%

Obesity in adolescents with chronic fatigue syndrome: an observational study

et al. 2016

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“…30–32 Indeed in this cohort, 16-year-old females had a similarly increased risk (OR 1.64 (1.00 to 2.70)) 18. However, this is different to 13 year olds and primary school children where the prevalence has been observed to be equal in males and females 1…”

Section: Discussionmentioning

confidence: 63%

“…Our method for defining CDF at age 16 years has been described previously 18. Briefly, a classification of CDF was based on both parental and child-reported data.…”

Section: Methodsmentioning

confidence: 99%

Natural course of chronic fatigue syndrome/myalgic encephalomyelitis in adolescents

et al. 2017

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ObjectiveLittle is known about persistence of or recovery from chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in adolescents. Previous studies have small sample sizes, short follow-up or have focused on fatigue rather than CFS/ME or, equivalently, chronic fatigue, which is disabling. This work aimed to describe the epidemiology and natural course of CFS/ME in adolescents aged 13–18 years.DesignLongitudinal follow-up of adolescents enrolled in the Avon Longitudinal Study of Parents and Children.SettingAvon, UK.ParticipantsWe identified adolescents who had disabling fatigue of >6 months duration without a known cause at ages 13, 16 and 18 years. We use the term ‘chronic disabling fatigue’ (CDF) because CFS/ME was not verified by clinical diagnosis. We used multiple imputation to obtain unbiased estimates of prevalence and persistence.ResultsThe estimated prevalence of CDF was 1.47% (95% CI 1.05% to 1.89%) at age 13, 2.22% (1.67% to 2.78%) at age 16 and 2.99% (2.24% to 3.75%) at age 18. Among adolescents with CDF of 6 months duration at 13 years 75.3% (64.0% to 86.6%) were not classified as such at age 16. Similar change was observed between 16 and 18 years (75.0% (62.8% to 87.2%)). Of those with CDF at age 13, 8.02% (0.61% to 15.4%) presented with CDF throughout the duration of adolescence.ConclusionsThe prevalence of CDF lasting 6 months or longer (a proxy for clinically diagnosed CFS/ME) increases from 13 to 18 years. However, persistent CDF is rare in adolescents, with approximately 75% recovering after 2–3 years.

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“…Over the last few decades, an alarming rise in the number of patients presenting with chronic pain or chronic fatigue has been observed in clinical practice [16,17]. In addition to markers of genetic predisposition, research into the etiology of CDAF may need to include the impact of the environmental factors, such as atmospheric pollutants, food preservatives, hormonal disruptors, agricultural pesticides, pharmaceutical excipients, and possible vaccine adjuvants, as potential activators of the immune system.…”

Section: Future Directionmentioning

confidence: 99%

Chronic Fatigue Syndrome: From Chronic Fatigue to More Specific Syndromes

Blitshteyn

Chopra

2018

Eur Neurol

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In the last decade, a group of chronic disorders associated with fatigue (CDAF) emerged as the leading cause of chronic fatigue, chronic pain, and functional impairment, all of which have been often labeled in clinical practice as chronic fatigue syndrome (CFS) or fibromyalgia. While these chronic disorders arise from various pathophysiologic mechanisms, a shared autoimmune or immune-mediated etiology could shift the focus from symptomatic treatment of fatigue and pain to targeted immunomodulatory and biological therapy. A clinical paradigm shift is necessary to reevaluate CFS and fibromyalgia diagnoses and its relationship to the CDAF entities, which would ultimately lead to a change in diagnostic and therapeutic algorithm for patients with chronic fatigue and chronic pain. Rather than uniformly apply the diagnoses of CFS or fibromyalgia to any patient presenting with unexplained chronic fatigue or chronic pain, it may be more beneficial and therapeutically effective to stratify these patients into more specific diagnoses in the CDAF group.

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Chronic Fatigue Syndrome at Age 16 Years

Abstract: BACKGROUND: In the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort, chronic disabling fatigue lasting ≥6 months affected 1.3% of 13-year-olds, was equally common in boys and girls, and became more prevalent with increasing family adversity.

Cited by 33 publications

References 43 publications

Obesity in adolescents with chronic fatigue syndrome: an observational study

Obesity in adolescents with chronic fatigue syndrome: an observational study

Natural course of chronic fatigue syndrome/myalgic encephalomyelitis in adolescents

Chronic Fatigue Syndrome: From Chronic Fatigue to More Specific Syndromes

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