Chronic fatigue syndrome in patients with macrophagic myofasciitis

Authier, François‐Jérôme; Sauvat, Stéphane; Julien, Claude; Drogou, Irène; Coquet, Michèle; Gherardi, Romain K.

doi:10.1002/art.10740

Cited by 58 publications

(40 citation statements)

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“…A low-dose helical CT was first performed for anatomical correlation and attenuation correction with the following parameters: x-ray tube tension of 120 kV, current of 80-100 mAs, rotation time 0.5 s, pitch 0.938, and slice thickness 2 mm. Images were reconstructed using line of response-row action maximum likelihood algorithm (two iterations, 28 subsets, postfilter 5.1 mm), with and without CT attenuation correction (matrix size of 512×512, voxel size 4×4×4 mm 3 ). Visual analysis of FDG PET/CT images (Fig.…”

Section: Case Reportmentioning

confidence: 99%

“…Dimensions of the resulting voxels were 2×2×2 mm 3 . Images were smoothed using a Gaussian filter (FWHM 10 mm) to blur individual variations in anatomy and to increase the signal-to-noise ratio.…”

Section: Case Reportmentioning

confidence: 99%

“…Clinical manifestations associated with MMF typically include arthromyalgias, chronic fatigue, and a cognitive dysfunction, occurring several months or years after the last vaccine injection combining impaired verbal long-term memory, dysexecutive syndrome, and more rarely an alteration of dichotic listening [3][4][5][6]. Only a very limited number of functional studies using the Single-Photon Emission Computed Tomography (SPECT) technique have investigated these cognitive disorders.…”

Section: Introductionmentioning

confidence: 99%

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FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis

Gucht¹,

Aoun-Sebaiti

Kauv

et al. 2015

Nucl Med Mol Imaging

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Brain Positron Emission Tomography/Computed Tomography with 18 F-fluorodeoxyglucose (FDG PET/CT) was performed in a 44-year-old woman with marked cognitive impairment, diffuse myalgias, sensory, memory and visual disorders, and chronic fatigue, presenting with histopathological features of macrophagic myofasciitis (MMF) at deltoid muscle biopsy. Cerebromedullary Magnetic Resonance Imaging (MRI), electromyography, ophthalmic examination, and cerebrospinal fluid analysis were normal. Visual analysis of FDG PET/CT images showed an atypical pattern of hypometabolism, involving symmetrically the occipital cortex, temporal lobes, and limbic system (including in particular amygdalo-hippocampal complexes), and the cerebellum. Posterior cingulate cortex and parietal areas were preserved. This pattern was confirmed by a voxel-based procedure using Statistical Parametric Mapping (SPM12) that compared a patient's images to normal reference samples from six healthy subjects with adjustment to age obtained using the same PET/CT camera. These results provide a glucose metabolism substrate for cognitive complaints in patients with long-lasting aluminium hydroxide-induced MMF.

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Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis

Gucht¹,

Aoun-Sebaiti

Kauv

et al. 2015

Nucl Med Mol Imaging

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“…However, as other effective medical compounds, vaccines may occasionally cause adverse effects. In particular, a condition manifesting by the combination of myalgia, arthralgia, chronic fatigue, cognitive dysfunction, dysautonomia and autoimmunity has been temporally linked to aluminium adjuvant-containing vaccine administration, called Macrophagic Myofasciitis (MMF) Authier et al, 2003;Exley et al, 2009;Rosenblum et al, 2011;Santiago et al, 2014;Brinth et al, 2015;Palmieri et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity

et al. 2017

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Nonlinear dose-response of aluminium hydroxide adjuvant particles: selective low dose neurotoxicity.Toxicology http://dx.doi.org/10.1016/j.tox. 2016.11.018 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. An unusual neuro-toxicological pattern limited to a low dose of Alhydrogel ® was observed.Neurobehavioural changes, including decreased activity levels and altered anxiety-like behaviour, were observed compared to controls in animals exposed to 200 µg Al/kg but not at 400 and 800 µg Al/kg. Consistently, microglial number appeared increased in the ventral forebrain of the 200 µg Al/kg group. Cerebral Al levels were selectively increased in animals exposed to the lowest dose, while muscle granulomas had almost completely disappeared at 6 months in these animals.We conclude that Alhydrogel® injected at low dose in mouse muscle may selectively induce long-term Al cerebral accumulation and neurotoxic effects. To explain this unexpected result, an avenue that could be explored in the future relates to the adjuvant size since the injected suspensions corresponding to the lowest dose, but not to the highest doses, exclusively contained small agglomerates in the bacteria-size range known to favour capture and, presumably, transportation by monocyte-lineage cells. In any event, the view that Alhydrogel® neurotoxicity obeys "the dose makes the poison" rule of classical chemical toxicity appears overly simplistic.

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“…Indeed, chronic pain, chronic fatigue states, and depressive syndromes are known to impair intellectual or cognitive performance. The prevalence of cognitive complaints ranged from 20% to 68% (4,(7)(8)(9)(10). MMF-associated cognitive dysfunction resembles that observed after chronic exposure to aluminum and in patients infected with hepatitis C virus or HIV (7).…”

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confidence: 90%

Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

Gucht¹,

Sebaiti²,

Guedj³

et al. 2016

J Nucl Med

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The aim of this study was to characterize brain metabolic abnormalities in patients with macrophagic myofascitis (MMF) and the relationship with cognitive dysfunction through the use of PET with 18 F-FDG. Methods: 18 F-FDG PET brain imaging and a comprehensive battery of neuropsychological tests were performed in 100 consecutive MMF patients (age [mean 6 SD], 45.9 6 12 y; 74% women). Images were analyzed with statistical parametric mapping (SPM12). Through the use of analysis of covariance, all 18 F-FDG PET brain images of MMF patients were compared with those of a reference population of 44 healthy subjects similar in age (45.4 6 16 y; P 5 0.87) and sex (73% women; P 5 0.88). The neuropsychological assessment identified 4 categories of patients: those with no significant cognitive impairment (n 5 42), those with frontal subcortical (FSC) dysfunction (n 5 29), those with Papez circuit dysfunction (n 5 22), and those with callosal disconnection (n 5 7). Results: In comparison with healthy subjects, the whole population of patients with MMF exhibited a spatial pattern of cerebral glucose hypometabolism (P , 0.001) involving the occipital lobes, temporal lobes, limbic system, cerebellum, and frontoparietal cortices, as shown by analysis of covariance. The subgroup of patients with FSC dysfunction exhibited a larger extent of involved areas (35,223 voxels vs. 13,680 voxels in the subgroup with Papez circuit dysfunction and 5,453 voxels in patients without cognitive impairment). Nonsignificant results were obtained for the last subgroup because of its small population size. Conclusion: Our study identified a peculiar spatial pattern of cerebral glucose hypometabolism that was most marked in MMF patients with FSC dysfunction. Further studies are needed to determine whether this pattern could represent a diagnostic biomarker of MMF in patients with chronic fatigue syndrome and cognitive dysfunction.

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Chronic fatigue syndrome in patients with macrophagic myofasciitis

Cited by 58 publications

References 10 publications

FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis

FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis

Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity

Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

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Chronic fatigue syndrome in patients with macrophagic myofasciitis

Cited by 58 publications

References 10 publications

FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis

FDG-PET/CT Brain Findings in a Patient With Macrophagic Myofasciitis

Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity

Brain 18F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

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Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis