Chronic feeding with 3% dried raw blueberries (V. corymbosum) reduces apomorphine-induced rotations and striatal dopaminergic loss in hemiparkinsonian rats

Parra-Paz, Valeria G.; Calderón-Sauri, Ashanty; Granados-Patrón, Diego; Cuevas-Carbonell, Sergio G.; García-López, Daniel; Dawn-Ojeda, Alicia; Mut-Martı́n, Mirza; Olivera‐Castillo, Leticia; Álvarez-Cervera, Fernando J.; Salgado, Humberto; Alamilla, Javier; García-Miss, María del Rosario; Vásquez-Celaya, Lizbeth; Aranda-González, Irma; Góngora-Alfaro, José L.

doi:10.1016/j.foodres.2020.110066

Cited by 8 publications

(3 citation statements)

References 54 publications

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“…Similarly, Sato et al (16) found that Montgomerym [Mont], a kind of blueberry cultivar, protects skeletal muscle loss induced by sex steroid de ciency. Study from Valeria et al (29) demonstrated that raw blueberries attenuated dopaminergic denervation and partially reversed motor disorders on rats. Inspired by previous discoveries, in this study, we tried blueberry extracts on mice undergone sciatic nerve transection and found its obvious protective effects on gastrocnemius.…”

Section: Discussionmentioning

confidence: 99%

Negative Effects of Cx43 during Denervated Skeletal Muscle Atrophy can be Attenuated by Blueberry Extracts via Regulating Akt Pathway

Huang

Zhang

You

et al. 2022

Preprint

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Background: Lack of effective treatment for alleviating the irreversible skeletal muscle atrophy caused by peripheral nerve disfunction has long been a clinical problem. For seeking therapeutic targets, several signaling pathways in muscle cells that activated by denervation have been explored. Important roles of Cx43 in other types of pathologic processes such as have been reported. Methods: Denervation mice model was created. Hematoxylin–Eosin (HE) and immunofluorescence staining were applied and analyzed. Western blot and quantitative real-time PCR (qPCR) were used. All statistical testing was performed by t test.Results: Our study investigated the negative role of Cx43 during muscle cells degeneration after denervation. Blueberry extracts was applied orally and its protective effect for denervated skeletal muscle atrophy was found in our study, and we demonstrated that Cx43/Akt pathway in denervated muscle cells was modulated by blueberry extracts. Conclusion: Negative effects of Cx43 during denervated skeletal muscle atrophy can be attenuated by blueberry extracts via regulating Akt pathway.

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Section: Discussionmentioning

confidence: 99%

Negative Effects of Cx43 during Denervated Skeletal Muscle Atrophy can be Attenuated by Blueberry Extracts via Regulating Akt Pathway

Huang

Zhang

You

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…The test was carried out 2 hours after the last i.p. injection, and asymmetry score was calculated as percent use of contralateral forelimb over total use of both forelimbs, as previously described ( Parra-Paz et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Antidepressant and Neuroprotective Effects of 3-Hydroxy Paroxetine, an Analog of Paroxetine in Rats

Hernández-Arrambide

Carrasco-Carballo

Parra

et al. 2022

International Journal of Neuropsychopharmacology

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Background Paroxetine (PX), is a widely used antidepressant with side effects such as weakness, dizziness and trouble sleeping. In search of novel compounds with better efficacy and less side effect, we synthesized 3HPX, a hydroxylated analog of PX, and compared the two in-silico for their pharmacokinetic and binding properties and in-vivo for their antidepressant and potential neuroprotective effects. Methods In-silico studies compared pharmacological properties as well as interactions of PX and 3HPX with the serotonin transporter. In-vivo studies utilized an animal model of comorbid depression-Parkinson’s disease (PD). Adult male Wistar rats were injected (sterotaxically) with lipopolysaccharide (LPS) in the striatum (unilaterally), followed by 14 days of once daily injection (i.p.) of 10 mg/kg of PX or 3HPX. Animals were tested for motor asymmetry and locomotor activity as well as indices of anhedonia and helplessness, using sucrose preference and forced swim tests, respectively. Brains of these animals were collected after the last test and tyrosine hydroxylase (TH) positive neurons in substantia nigra pars compacta (SNpc) and Iba-1 positive stained microglia in ipsilateral striatum were measured. Results In-silico findings indicated that 3HPX could bind stronger to serotonin transporter and also have a better clearance and hence less toxicity compared to PX. In-vivo results revealed a more effective reversal of immobility in the swim test, substantial increase in TH + cells in SNpc, and more ramified Iba-1 + cells by 3HPX compared to PX. Conclusion The findings suggest superior effectiveness of 3HPX as an antidepressant and neuroprotectant compared to PX and hence potential utility in PD-depression co-morbidity.

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“…1). 44,[48][49][50][51][52][53] Although unravelling the biological function continues to be a cornerstone of the development of new functional foods or ingredients, in addition to specific bioactivities, the current challenges involve the effect of gastrointestinal digestion and the absorption of bioactive compounds because these processes condition the concentration of phytochemicals in cells and, thereby, the bioactivity. Hence, this review summarizes the most relevant findings described in recent years concerning the relationship between food components and molecular pathways related to relevant pathophysiological conditions.…”

Section: Introductionmentioning

confidence: 99%

Contribution of the diverse experimental models to unravelling the biological scope of dietary (poly)phenols

et al. 2022

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The health benefits associated with (poly)phenols need to be supported by robust and insightful information on their biological effects. The use of in vitro, ex vivo, and in vivo models is crucial to demonstrate functionalities in specific targets. In this regard, bioaccessibility, bioavailability, and tissue/organ distribution need to be fully understood and established. In addition, the structure–function relationships, concerning both descriptive and mechanistic information, between specific compounds and therapeutic objectives, need to be supported by results obtained from in vivo studies. Nevertheless, these studies are not always possible or have some limitations, particularly concerning the mechanistic information explaining the health benefits provided that should be covered with complementary experimental models. Based on these premises, this review aims to overview the contribution of the separate experimental approaches to gain insights into the bioaccessibility, bioavailability, and bioactivity of (poly)phenols. To achieve this objective, recent evidence available on the linkage of healthy/functional foods with the incidence of non‐communicable pathologies is presented. The different experimental approaches provide complementary information that allows advances to be applied to the knowledge gained on the functional properties and mechanistic facts responsible for the health attributions of polyphenols. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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Chronic feeding with 3% dried raw blueberries (V. corymbosum) reduces apomorphine-induced rotations and striatal dopaminergic loss in hemiparkinsonian rats

Cited by 8 publications

References 54 publications

Negative Effects of Cx43 during Denervated Skeletal Muscle Atrophy can be Attenuated by Blueberry Extracts via Regulating Akt Pathway

Negative Effects of Cx43 during Denervated Skeletal Muscle Atrophy can be Attenuated by Blueberry Extracts via Regulating Akt Pathway

Antidepressant and Neuroprotective Effects of 3-Hydroxy Paroxetine, an Analog of Paroxetine in Rats

Contribution of the diverse experimental models to unravelling the biological scope of dietary (poly)phenols

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