Chronic fluoxetine treatment enhances sympathetic activities associated with abnormality of baroreflex function in conscious normal rats

Hong, Ling-Zong; Huang, Keh‐Feng; Hung, Shao-Wen; Kuo, Li-Te

doi:10.1016/j.ejphar.2017.06.021

Cited by 14 publications

(6 citation statements)

References 34 publications

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“…7 These cardiovascular effects would be the central effects of FLX on the brain's serotonergic system. 32 In conclusion, the present study provides evidence in our perception of the cardiac and hepatic adverse effects of FLX. Further studies are required to understand the underlying mechanisms of the observed impairments following FLX treatment.…”

Section: Discussionsupporting

confidence: 59%

Cardiac and hepatic side effects of fluoxetine in male and female adolescent rats

Babaaeyan,

Sakhaie,

Sadegzadeh

et al. 2023

Fundamemntal Clinical Pharma

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BackgroundFluoxetine (FLX) is widely prescribed as an antidepressant medicine in the juvenile population.ObjectivesAlthough some adverse effects of FLX have been reported in adults, the present study aimed to investigate the side effects of FLX treatment during adolescence on the cardiac and hepatic systems.MethodsMale and female rats were gavaged with FLX (5 mg/kg/day) on postnatal days (PND) 21 to PND 60. Following treatment, blood samples were collected and hepatic enzymes were evaluated. The specimens of the liver and heart of animals were subjected to histopathological assessment.ResultsFluoxetine significantly raised serum alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in males, whereas the aspartate aminotransferase (AST) level increased in both male and female animals. In the histopathological study, hepatic plates were more seriously affected, and the sinusoids were irregular in adolescent male rats. Degenerative changes were observed especially in the first and second hepatic zones of FLX‐treated male rats. Signs of inflammation and accumulation of lymphoid groups were frequently observed in the portal triad of the hepatic lobules. These alterations were more severe in male livers. Minimum or nearly normal changes were observed in female liver slides. In addition, the histological assessment indicated that treatment with FLX during adolescence also increased the heart's weight and the wall thickness of the right and left ventricles (hypertrophy) in male and especially female animals.ConclusionOur findings may provide new insights into the cardiac and hepatic adverse effects of FLX.

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Section: Discussionsupporting

confidence: 59%

Cardiac and hepatic side effects of fluoxetine in male and female adolescent rats

Babaaeyan,

Sakhaie,

Sadegzadeh

et al. 2023

Fundamemntal Clinical Pharma

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“…Overall, ALA stabilized mood and emotions as well as reward functions and augmented the anxiety, aggression, improved memory functions. FLX also signi cantly elevated 5HT, DA, and NE levels but very high levels of NE had a detrimental effect on cardiovascular function (Hong et al, 2017). Therefore, it can be hypothesized that behaviour de cits associated with CUMS are alleviated by ALA by increasing DA, 5-HT, and NE to an optimum level due to its strong antioxidant and neuroprotective effects.…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Modulation of CUMS Induced Behaviour Deficits in Rats by Alpha Lipoic Acid: Possible Involvement of Dopaminergic and Serotonergic Neurotransmission

Akotkar

Urmila

Patil

et al. 2022

Preprint

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Purpose: Stress is an important factor having a high impact on psychological development which alters emotion, cognition and related behavioural outputs. Alpha lipoic acid (ALA) is a potent neuroprotectant and antioxidant; however, it has not been studied in clinically relevant, chronic unpredictable mild stress (CUMS) induced behaviour deficits model in rats as well as its mechanism of action is unclear. Hence, the purpose of this study was to determine its antidepressant activity in CUMS induced depression-like behaviour and to understand its mechanism of action using brain monoamine estimations and molecular docking study.Methods: The Wistar rats were divided into 6 groups. Group I vehicle control (without stress), Group II- CUMS, Group III- fluoxetine (FLX) (50 mg/kg), Group IV, V, and VI were treated with ALA (50, 100, 200 mg/kg, p.o.) respectively. All the groups, except I, were subjected to CUMS along with the treatments which were given orally from day 1 to day 42. The behavioural parameters like sucrose preference test (SPT), Morris water maze (MWM), resident intruder test (RIT), marble-burying test (MBT) were performed on day 0, day 21, and day 42 and forced swim test (FST) on day 42 only. Animals were sacrificed at the end of the study; the brain homogenate was prepared and used for the antioxidant, histopathology and monoamine estimations.Results: When compared with CUMS group, ALA (50, 100, 200) treatment displays improved behavioural parameters, increased GSH, SOD, catalase and reduced MDA, NO. Concentrations of monoamines (5-HT, DA, NE) were also found to be restored in brain homogenate. Histopathological results indicated the protection of CA3 neurons in the hippocampus. Computational molecular docking revealed strong binding of ALA on the 5HT3 receptor. Conclusion: Consequently, the study demonstrates that ALA might be exhibiting antidepressant effects in part by restoring monoamines as well as may be modulating the 5HT3 receptor.

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“… 85 Fluoxetine Pharmaceutical Golub et al [ 229 ]: provoked greater dendritic spine synapse density in prefrontal cortex of monkeys. Hong et al [ 230 ]: induced predominant sympatho-excitation and depressed parasympathetic activity leading to mild hypertension, tachycardia, and impairment of baroreflex function. Sprowles et al [ 131 ]: Differential effects of perinatal exposure to antidepressants on learning and memory, acoustic startle, anxiety, and open-field activity in rats.…”

Section: Resultsmentioning

confidence: 99%

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

Séralini

Jungers

2021

Toxicology Reports

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Chronic fluoxetine treatment enhances sympathetic activities associated with abnormality of baroreflex function in conscious normal rats

Cited by 14 publications

References 34 publications

Cardiac and hepatic side effects of fluoxetine in male and female adolescent rats

Cardiac and hepatic side effects of fluoxetine in male and female adolescent rats

WITHDRAWN: Modulation of CUMS Induced Behaviour Deficits in Rats by Alpha Lipoic Acid: Possible Involvement of Dopaminergic and Serotonergic Neurotransmission

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

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