Chronic fungal sinusitis leading to disastrous cerebral aspergillosis: a case report

Popalzai, Muhammad; Kushawaha, Anurag; Mobarakai, Neville; Asrar, Rohail; Durrani, Farida

doi:10.1186/1757-1626-2-9406

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…Aspergillus species are usually isolated from these cases. 4,5 Delay in diagnosis is a typical finding across the literature; moreover, the ideal management approach is controversial and is subject to several influencing factors such as the nature of the disease, the degree of tissue invasion, and patient comorbidities. 6 In view of the paucity of reports on CGIFS, we present 7 cases of patients diagnosed with the disease and we review the pertinent literature.…”

Section: Introductionmentioning

confidence: 99%

Chronic Granulomatous Invasive Fungal Sinusitis: A Case Series and Literature Review

et al. 2020

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Chronic granulomatous invasive fungal sinusitis (CGIFS) is a peculiar disease of the paranasal sinuses due to its rarity, patient subset, and disease course. We describe 7 cases of histopathologically confirmed CGIFS with different treatment plans and varying outcomes. Of particular note was that one of these patients developed allergic fungal rhinosinusitis after complete resolution of his primary invasive disease, a finding that has never been reported in the literature. Another patient had an atypical fungal species ( Aspergillus nidulans) on fungal stain and culture, while one immunodeficient patient had a large intracerebral disease component and died after 2 months of treatment. We also present a review of the pertinent literature investigating this rare disease.

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Section: Introductionmentioning

confidence: 99%

Chronic Granulomatous Invasive Fungal Sinusitis: A Case Series and Literature Review

et al. 2020

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“…It is found that invasive cerebral aspergillosis is a complicated and quick progressive disease that cause high mortality rate up to hundred percent even with effective management. 1 Aspergillus species can invade cerebral vessels leading to different pathologies including infarction or hemorrhage leading to progressive inflammation.…”

Section: Therapeutic Interventionsmentioning

confidence: 99%

“…Acute invasive fungal sinusitis results from a rapid spread of fungi through vascular invasion into the orbit Invasive aspergillus sinusitis of this patient showed invasive complications that rarely happened in other populations based on previous researches of meningitis as seen on time line Table 1, orbital involvement, skull base erosion with intracranial extension, and infratemporal fossa extension multiple vasculitis with diffuse brain edema and hydrocephalous. 1,2 The likely pathogenesis of cerebral infarction is by direct angioinvasion and less likely compression by oedema.…”

Section: Therapeutic Interventionsmentioning

confidence: 99%

“…According to other researches, chronic invasive sinonasal aspergillosis has been documented in immunocompetent patients living in dry-air climates similar to desert Sahara and Middle Eastern countries. 1,5 Prognosis of acute invasive fungal sinusitis is often misleading, it carries a poor prognosis. Mortality rate is reported at 50%, even with aggressive surgical and medical treatment, 3,4 Relapses are common during subsequent episodes of neutropenia.…”

Section: Therapeutic Interventionsmentioning

confidence: 99%

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Aspergillus sinusitis complicated with meningitis and multiple cerebral infarctions in immunocompetent patient

Houssen

Algreeshah

2018

NSJ

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33 ‫العمر‬ ‫من‬ ‫يبلغ‬ ‫ذكر‬ ‫مريض‬ ‫حالة‬ ‫التقرير‬ ‫هذا‬ ‫في‬ ‫نستعرض‬ ‫الضوء،‬ ‫وخوف‬ ‫الرقبة،‬ ‫في‬ ‫وآالالم‬ ‫حاد،‬ ‫صداع‬ ‫من‬ ‫يعاني‬ ‫عام‬ ‫أن‬ ‫بالذكر‬ ‫اجلدير‬ ‫أيام.‬ ‫لعدة‬ ‫احلرارة‬ ‫درجة‬ ‫في‬ ‫وارتفاع‬ ‫واستفراغ،‬ ‫للجيوب‬ ‫مزمن‬ ‫التهاب‬ ‫مع‬ ‫أنفية‬ ‫لسليلة‬ ‫إزالة‬ ‫بعملية‬ ‫قام‬ ‫املريض‬ ‫للمريض‬ ‫السريري‬ ‫الفحص‬ ‫خالل‬ ‫املاضية.‬ ‫السنوات‬ ‫الثمان‬ ‫األنفية‬ ‫طبيعية‬ ‫قوى‬ ‫مع‬ 15/15 ‫جالسكو‬ ‫مقياس‬ ‫على‬ ‫الوعي‬ ‫مستوى‬ ‫كان‬ ‫املالحظة‬ ‫من‬ ‫ملزيد‬ ‫إيجابية.‬ ‫بابينسكي‬ ‫عالمة‬ ‫وكانت‬ ‫باألطراف‬ ‫الفحوصات‬ ‫جميع‬ ‫وعمل‬ ‫املستشفى‬ ‫في‬ ‫تنوميه‬ ‫مت‬ ‫أكثر،‬ ‫بشكل‬ ‫احليوية‬ ‫املضادات‬ ‫إعطاء‬ ‫في‬ ‫البدء‬ ‫من‬ ‫الرغم‬ ‫على‬ ‫الالزمة.‬ ‫وإمنا‬ ‫حالته‬ ‫في‬ ‫مباشر‬ ‫حتسن‬ ‫أي‬ ‫يظهر‬ ‫لم‬ ‫املريض‬ ‫أن‬ ‫إال‬ ‫االختبارية‬ ‫في‬ ‫واستسقاء‬ ‫بصري،‬ ‫عجز‬ ‫بسبب:‬ ‫مثير‬ ‫بشكل‬ ‫حالته‬ ‫تدهورت‬ ‫متعددة‬ ‫دماغية‬ ‫واحتشاءات‬ ‫الوعي،‬ ‫مستوى‬ ‫في‬ ‫تدني‬ ‫مع‬ ‫الدماغ‬ ‫عملية‬ ‫عمل‬ ‫مت‬ ‫اللحظة،‬ ‫تلك‬ ‫بعد‬ ‫الدماغ.‬ ‫أنحاء‬ ‫مختلف‬ ‫في‬ ‫إعطاء‬ ‫في‬ ‫االستمرار‬ ‫مع‬ ‫الدماغ‬ ‫عن‬ ‫الضغط‬ ‫إلزالة‬ ‫القحف‬ ‫قطع‬ ‫مستوى‬ ‫تدنى‬ ‫ذلك‬ ‫مع‬ ‫الفطريات.‬ ‫ومضادات‬ ‫احليوية‬ ‫املضادات‬ ‫اإلنعاش‬ ‫ينجح‬ ‫ولم‬ ‫جالسكو،‬ ‫مقياس‬ ‫على‬ 3/15 ‫إلى‬ ‫الوعي‬ ‫اجلدير‬ ‫من‬ ‫التالي.‬ ‫اليوم‬ ‫في‬ ‫وتوفى‬ ‫املريض‬ ‫احياء‬ ‫في‬ ‫الرئوي‬ ‫القلبي‬ ‫خطيرة،‬ ‫مضاعفات‬ ‫إلى‬ ‫يؤدي‬ ‫أن‬ ‫ميكن‬ ‫الرشاشيات‬ ‫داء‬ ‫أن‬ ‫لالنتباه‬ ‫والعالج.‬ ‫التشخيص‬ ‫في‬ ‫التأخر‬ ‫عدم‬ ‫من‬ ‫البد‬ ‫لذا‬ This is a case of a 33-year-old male complaining of severe headache, neck pain, photophobia, vomiting and high-grade fever of several days. He had history of nasal polyp removal and recurrent sinusitis in the last 8 years. On examination: conscious with glasco coma scale (GCS) 15/15 and normal limbs strength butwith positive Babinski sign. For further observation, he was admitted and full work-up was done. Even though full empirical antibiotics were started, there was no immediate improvement and he deteriorated dramatically developing ocular deficit, hydrocephalus and lower level of consciousness with multiple infarctions found at different areas in brain. After that point, a decompressive craniectomy was done, and multiple antibiotics and antifungal medications were prescribed. However, he deteriorated to GCS 3/15; cardiopulmonary resuscitations were not successful, as he demised next day. It shall be noted that aspergillosis can lead to difficult complications, so diagnosis and treatments should not be delayed.

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Cerebral Aspergillosis in a Diabetic Patient Leading to Cerebral Artery Occlusion and Ischemic Stroke: A Case Report and Literature Review

Shafi

Periakaruppan

et al. 2015

Journal of Stroke and Cerebrovascular Diseases

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Chronic fungal sinusitis leading to disastrous cerebral aspergillosis: a case report

Cited by 6 publications

References 9 publications

Chronic Granulomatous Invasive Fungal Sinusitis: A Case Series and Literature Review

Chronic Granulomatous Invasive Fungal Sinusitis: A Case Series and Literature Review

Aspergillus sinusitis complicated with meningitis and multiple cerebral infarctions in immunocompetent patient

Cerebral Aspergillosis in a Diabetic Patient Leading to Cerebral Artery Occlusion and Ischemic Stroke: A Case Report and Literature Review

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