Chronic Gastritis Associated with <i>Helicobacter pylori</i> in Mexican Children: Histopathological Patterns

Jaramillo-Rodríguez, Yolanda; Nares-Cisneros, Jesús; Martínez-Ordaz, Verónica Araceli; Velasco-Rodríguez, Víctor Manuel; Márquez, Francisco Carlos López; Manriquez-Covarrubias, Luis

doi:10.2350/09-12-0754-oa.1

Cited by 13 publications

(14 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When assessing the topographic distribution of the inflammation, we noticed a significant predominance of pangastritis (p = 0.04). Our observation contrasts with most of the previous reports that point out that histopathological changes are primarily limited to the antral mucosa [27].…”

Section: Discussioncontrasting

confidence: 99%

Helicobacter pylori Gastritis in Children—The Link between Endoscopy and Histology

Domșa

Lupușoru

Gheban

et al. 2020

JCM

View full text Add to dashboard Cite

Background: The management of Helicobacter pylori (H. pylori) infection raises important challenges, still being the most common chronic infection worldwide in all age groups. In high-prevalence regions, paediatric patients need a specific focus, as the acquisition of the infection takes place in childhood. The objective of this study was to analyze the endoscopic and histopathologic changes of the gastric mucosa in H. pylori infected children. Material and Methods: A retrospective study was performed on consecutive paediatric patients, ranging from 0 to 18 years of age, who underwent an upper gastrointestinal endoscopy (UGE) for a period of 5 years, regardless of their symptomatology. Endoscopy reports and histological slides were reviewed and clinical, endoscopic, and histologic data were recorded. Results: A total of 248 patients were included in the study, 82 (33.06%) of them being H. pylori infected. There was no difference in age and symptoms between the infected and noninfected group. A significant association was found between the H. pylori infection and histopathological parameters such as acute and chronic inflammatory infiltrate. The bacterial load influences the intensity of inflammation (p < 0.001). The chronic inflammation was predominant, only 23.2% of the patients displayed acute inflammation (p < 0.0001). The topographic distribution of inflammation was dominated by pangastritis (p = 0.04) with 58.6% of the patients presenting similar degrees of inflammation both in the antrum and corpus. Conclusion: Endoscopic features such as nodularity of the antral mucosa (p < 0.05) along with histological findings as lymphoid follicles (p < 0.05) are suggestive of H. pylori infection. However, the concordance between the endoscopic and histological diagnosis is still far from perfect (Cohen’s k coefficient = 0.42), maintaining the need for an invasive approach in children.

show abstract

Section: Discussioncontrasting

confidence: 99%

Helicobacter pylori Gastritis in Children—The Link between Endoscopy and Histology

Domșa

Lupușoru

Gheban

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…Generally, the patients in the present study had a low prevalence of chronic atrophic gastritis, and no patients had severe chronic atrophic gastritis or intestinal metaplasia. Researchers from different countries have reported a varied incidence of gastric atrophy (0-72%) and intestinal metaplasia ( 0-21% ) in children (11,(25)(26)(27)(28). Genetic and environmental factors other than H. pylori infection may explain the striking differences.…”

Section: Discussionmentioning

confidence: 99%

Association between <i>Helicobacter pylori</i> Infection and Pathological Changes in the Gastric Mucosa in Chinese Children

Wang

et al. 2014

Intern. Med.

View full text Add to dashboard Cite

Objective H. pylori infection in children has a high prevalence worldwide. The disease can cause progressive gastric mucosal inflammation, as verified in animal models. However, data from large-scale clinical studies are limited. Methods We examined 1,634 Chinese children with upper gastrointestinal discomfort using endoscopy. The clinical and pathological data of the patients were analyzed. Results A total of 524 (32.1%) patients were infected with H. pylori, and the prevalence of H. pylori infection increased with age. The H. pylori-infected patients exhibited a significantly higher prevalence of active inflammation (26.9% vs. 4.1%), lymphoid follicle formation (18.5% vs. 4.6%) and marked lymphocyte infiltration (19.7% vs. 5.6%). The H. pylori-infected patients also exhibited a significantly higher prevalence of moderate to marked chronic superficial gastritis (41.9% vs. 9.2%) and moderate chronic atrophic gastritis (21.7% vs. 2.6%) than the uninfected patients (p<0.01). Conclusion H. pylori infection is associated with the degree of gastric mucosal inflammation and the severity of different types of chronic gastritis.

show abstract

“…This is notable considering that IM and atrophy are relatively rare in other reported studies of pediatric gastritis 6,21, 22 . As CDX2 is expressed early in the IM progression pathway, ectopic antral CDX2 probably reflects pathologic changes leading to IM 3 .…”

Section: Discussionmentioning

confidence: 64%

Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican children with Helicobacter pylori–positive and Helicobacter pylori–negative gastritis

Villarreal-Calderon

Luévano-González

Aragón-Flores

et al. 2014

Annals of Diagnostic Pathology

View full text Add to dashboard Cite

Chronic inflammation and infection are major risk factors for gastric carcinogenesis in adults. As chronic gastritis is common in Mexican children, diagnosis of Helicobacter pylori and other causes of gastritis are critical for the identification of children who would benefit from closer surveillance. Antral biopsies from 82 Mexican children (mean age 8.3±4.8y) with chronic gastritis (36 H. pylori +, 46 H. pylori -) were examined for gastritis activity, atrophy, intestinal metaplasia, and immunohistochemical expression of gastric carcinogenesis biomarkers CDX2, ephrin type-B receptor 4, matrix metalloproteinase 3 (MMP3), macrophage migration inhibitory factor (MIF), p53, β-catenin, and E-cadherin. Atrophy was diagnosed in 7/82 (9%) and intestinal metaplasia in 5/82 (6%) by routine histology, while 6 (7%) additional children (3 H. pylori +) exhibited aberrant CDX2 expression without intestinal metaplasia. Significant positive correlations were seen between EphB4, MMP3, and MIF (p<0.0001). Atrophy and follicular pathology were more frequent in H. pylori + biopsies (p<0.0001), while intestinal metaplasia and CDX2 expression showed no significant correlation with H. pylori status. Antral biopsies demonstrating atrophy, intestinal metaplasia, and/or aberrant CDX2 expression were seen in 21.95 % (18/82) of the children, potentially identifying those who would benefit from closer surveillance and preventive dietary strategies. Biomarkers CDX2, EphB4, MMP3, and MIF may be useful in the work-up of pediatric gastritis.

show abstract

Chronic Gastritis Associated with Helicobacter pylori in Mexican Children: Histopathological Patterns

Cited by 13 publications

References 31 publications

Helicobacter pylori Gastritis in Children—The Link between Endoscopy and Histology

Helicobacter pylori Gastritis in Children—The Link between Endoscopy and Histology

Association between <i>Helicobacter pylori</i> Infection and Pathological Changes in the Gastric Mucosa in Chinese Children

Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican children with Helicobacter pylori–positive and Helicobacter pylori–negative gastritis

Contact Info

Product

Resources

About