Chronic Gastritis

Lambert, René

doi:10.1159/000197264

Cited by 49 publications

(5 citation statements)

References 21 publications

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“…Specifically, of biopsy site is not always as clear-cut as under direct vision. AMMM a ,^sWe did not observe a number of features described in chronic gastritis by others-namely, degenerative and regenerative changes of the superficial mucosa (Whitehead et al, 1972) and fibrosis of the lamina iit EIEi | propria (Lambert, 1972). In many of our cases of PA endocrine cells have been prominent, and, in three, florid proliferations of these cells almost replaced entire gastric glands in the body and pylorus.…”

Section: Discussioncontrasting

confidence: 40%

Gastric morphology and serum gastrin levels in pernicious anaemia.

Lewin¹,

Dowling²,

Wright³

et al. 1976

Gut

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SUMMARY Mucosal biopsies from multiple sites in the stomachs of 21 patients with pernicious anaemia have been examined. The histological changes almost always involved the entire gastric mucosa, including that of the pyloric antrum. Metaplastic changes were almost universal and consisted of intestinal metaplasia in the body and antrum and pyloric metaplasia in the body. The severity of the pyloric metaplasia was such as to make the distinction between body and antrum on biopsy impossible. No relationship was found between serum gastrin activity and the histological appearances of the gastric antrum or body.The past 25 years have witnessed the introduction of techniques whose application has contributed substantially to the investigation of the nature of chronic gastritis. Peroral suction biopsy (Wood et al., 1949;Joske et al., 1955) of the body and fundus of the stomach has provided a solid histological foundation which, in conjunction with measurements of gastric secretion of acid (Bock et al., 1963) and intrinsic factor and the detection of gastric antibodies (te Velde et al., 1966;Fisher et al., 1967), has considerably extended our knowledge of the pathophysiology of the body of the stomach.In contrast, the structure and function of the gastric antrum was until recently little studied. The introduction of the fibreoptic gastroscope made possible multiple biopsying of the gastric mucosa from well-defined sites in the body and pyloric antrum (Seifert and Knoll, 1968;Konturek and Urban, 1969; Ottenjann et al., 1969a, b) Methods PATIENTSEighteen patients (14 women and four men) referred to our clinic at Stanford University Medical Center with established or suspected PA were studied. Diagnosis was established by failure to secrete detectable acid in response to a maximal dose of gastric stimulant (betazole 1-7 mg/kg body weight) and urinary excretion of less than 10% of a 0-5 Kg oral dose of 57Co B12 in a standard Schilling test, which was corrected with added gastric intrinsic factor. Supporting evidence was low serum vitamin B12 activity, low or absent gastric intrinsic factor secretion, and the presence of circulating gastric antibodies.In addition, studies are included of three patients who were referred for suspected PA but in whom the above criteria were not completely fulfilled (Table 1).

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Section: Discussioncontrasting

confidence: 40%

Gastric morphology and serum gastrin levels in pernicious anaemia.

Lewin¹,

Dowling²,

Wright³

et al. 1976

Gut

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“…The presence and distribution of acute and chronic inflammatory cells including plasma cells and eosinophils, of lymphoid follicles, and of fibrosis in the lamina propria were also determined. Gastric biopsies were evaluated for chronic gastritis according to the classical qualitative criteria (12,25) as well as quanti tatively using the mononuclear inflammatory cell counting technique described above and reported previously (16).…”

Section: Methodsmentioning

confidence: 99%

Pathological and Histomorphometric Study of the Effects of Alcohol on the Human Duodenum

Lev¹,

Thomas²,

Parl³

et al. 1980

Digestion

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Duodenal biopsies from 47 alcoholic patients and 21 nonalcoholics were examined histologically and the number of chronic inflammatory (mononuclear) cells in the lamina propria and of villus goblet cells was calculated using a cell-counting technique. The number of mononuclear cells was the same in both groups. Goblet cell hyperplasia, gastric metaplasia and changes in the villi and epithelium were found almost exclusively in the alcoholics. Mononuclear cell counts were higher in patients from both groups showing concomitant chronic gastritis. Goblet cells were more numerous in older patients; mononuclear cells in nonalcoholics showed a slight increase with age. Correlation between endoscopy and histology gave equivocal results.

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“…[6][7][8] The type of operation for benign peptic ulcer disease (gastric resection or gastroenterostomy) does not appear to affect the subsequent late development of cancer.5-9 Operations for peptic ulcer disease result in hypochlorhydria or achlorhydria and increased biliary and pancreatic reflux, and it is believed that these factors lead to chronic atrophic gastritis and intestinal metaplasia, which may then progress to carcinoma.9 10 Both of these lesions occur in up to half of patients who have had a gastrectomy" and as a marker for gastric cancer are far too frequent a finding. Morson et al" drew attention to the relevance of epithelial dysplasia as a premalignant condition and suggested a prospective study to evaluate its role as an epidemiological marker for gastric cancer.…”

mentioning

confidence: 99%

Endoscopic review of patients who have had gastric surgery.

Farrands¹,

Blake²,

Ansell³

et al. 1983

BMJ

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Seventy one patients who had had operations on their stomachs over 15 years previously were examined by endoscopy and multiple mucosal biopsy sampling. Sixty six had histologically proved gastritis (56 chronic atrophic gastritis, 10 superficial gastritis), 38 intestinal metaplasia, and 11 epithelial dysplasia. In three cases the epithelial dysplasia was severe (carcinoma in situ). One patient had an infiltrating carcinoma and another, whose biopsy appearances were reported as severe dysplasia, developed a carcinoma of the stomach eight months later.All patients having undergone gastric surgery more than five years previously should be screened endoscopically and any found to have moderate dysplasia subjected to regular endoscopic screening thereafter. Patients with severe dysplasia (carcinoma in situ) should be considered for radical surgery.

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Chronic Gastritis

Cited by 49 publications

References 21 publications

Gastric morphology and serum gastrin levels in pernicious anaemia.

Gastric morphology and serum gastrin levels in pernicious anaemia.

Pathological and Histomorphometric Study of the Effects of Alcohol on the Human Duodenum

Endoscopic review of patients who have had gastric surgery.

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