Chronic graft-versus-host disease: clinical presentation of multiple lesions of lichenoid and atrophic pattern

Abstract

Graft-versus-host disease is observed mainly in recipients of hematopoietic cell transplantation and is expressed by cutaneous or systemic signals and symptoms. Graft-versus-host disease is clinically classified as acute or chronic. Chronic Graft-versus-host disease occurs in up to 70% of hematopoietic cell transplanted patients and its clinical manifestations have important impact on morbidity and quality of life. The authors report an expressive cutaneous, oral and adnexal involvement in a patient with chronic Graft-versus-host disease with multiple lesions of lichenoid and atrophic pattern.

Disorders of Hair

“…Sclerotic lesions in chronic GVHD can appear on any body site and in the case of involvement of scalp, and the result is scarring alopecia (Tekin et al 2005). • Clinical feature: This form of scarring alopecia is often presents with firm, hyperpigmented, hypopigmented, or skin-colored plaques with sparse and fragile hairs (Vasconcelos et al 2013). • Pathological manifestation: There is a reduction in the number of a hair follicles, concentric perifollicular fibrosis with lymphocytic infiltrate, vacuolization of the basal layer of the epidermis, and fibrous scarring tracts (Basilio et al 2015).…”

“…• Pathological manifestation: There is a reduction in the number of a hair follicles, concentric perifollicular fibrosis with lymphocytic infiltrate, vacuolization of the basal layer of the epidermis, and fibrous scarring tracts (Basilio et al 2015). • Prognosis and treatment: Oral corticosteroids and immunosupressive agents are the first line of therapy for cutaneous manifestations of chronic GVHD (Vasconcelos et al 2013). PUVA therapy, in addition to mentioned treatments, can give good results (Tekin et al 2005).…”