2023
DOI: 10.1016/j.isci.2023.107580
|View full text |Cite
|
Sign up to set email alerts
|

Chronic HDM exposure shows time-of-day and sex-based differences in inflammatory response associated with lung circadian clock disruption

Ashokkumar Srinivasan,
Allan Giri,
Santhosh Kumar Duraisamy
et al.
Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
2
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 7 publications
(2 citation statements)
references
References 62 publications
0
2
0
Order By: Relevance
“…In the current experiment, we chose to evaluate the pharmacological effects of Bronchom in female mice, on the basis of a previously published comprehensive study, which solely characterized the development of HDM induced-chronic airway inflammation and airway remodeling in mice (8). Furthermore, previously reported studies have established that female mice are more prone for the development of chronic asthma, subsequent to challenge with HDM, largely due to Th2 cytokine release and humoral response, resulting in higher numbers of eosinophils and more responsiveness to methacholine, when compared to male animals (22,23). The test article, Bronchom demonstrated promising efficacy by reducing the development of HDM-induced functional, cytological, histopathological, biochemical and molecular alterations.…”
Section: Discussionmentioning
confidence: 99%
“…In the current experiment, we chose to evaluate the pharmacological effects of Bronchom in female mice, on the basis of a previously published comprehensive study, which solely characterized the development of HDM induced-chronic airway inflammation and airway remodeling in mice (8). Furthermore, previously reported studies have established that female mice are more prone for the development of chronic asthma, subsequent to challenge with HDM, largely due to Th2 cytokine release and humoral response, resulting in higher numbers of eosinophils and more responsiveness to methacholine, when compared to male animals (22,23). The test article, Bronchom demonstrated promising efficacy by reducing the development of HDM-induced functional, cytological, histopathological, biochemical and molecular alterations.…”
Section: Discussionmentioning
confidence: 99%
“…The above‐mentioned findings corroborate with lung function parameters that showed significantly reduced lung function at ZT0 versus ZT12 BLM group for time‐of‐day response. Existing studies from the circadian clock in lung injury models conduct exposures and functional measurements at the same time to determine time‐of‐day response (e.g., ZT0 vs. ZT12) (Durrington et al, 2020 ; Hwang et al, 2014 ; Srinivasan et al, 2023 ; Wang et al, 2023 ). Hence, we followed a similar experimental design for the BLM‐induced lung injury model to measure lung function changes post‐BLM challenge at ZT0 or ZT12.…”
Section: Discussionmentioning
confidence: 99%