Chronic Heat Stress Inhibits Immune Responses to H5N1 Vaccination through Regulating CD4+CD25+Foxp3+Tregs

Meng, Di; Hu, Yanxin; Xiao, Cheng; Wei, Tangting; Zou, Qiang; Wang, Ming

doi:10.1155/2013/160859

Cited by 21 publications

(15 citation statements)

References 24 publications

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“…Influenza virus is an enveloped virus of the Orthomyxoviridae family, which has a unique capacity for genetic variation that is based in two molecular features of the virus family [ 1 ]. Because of the high degree of virus variability, cellular responses directed in particular against more conserved internal proteins have been investigated, involving CD4 + T cells and CD8 + T cells that are able to recognize epitopes shared by several subtypes [ 2 , 3 ]. In cellular responses, IFN- γ producing cells can favor viral elimination from nasal tissues, and more generally, IFN- γ plays a critical role in cell-mediated immunity, stimulating NK cells and macrophages activity.…”

Section: Introductionmentioning

confidence: 99%

Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma

Chu

Zhang

et al. 2015

BioMed Research International

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Baicalin (BA) is a flavonoid compound purified from Scutellaria baicalensis Georgi and has been shown to possess a potent inhibitory activity against viruses. However, the role of BA in anti-influenza virus has not been extensively studied, and the immunological mechanism of BA in antiviral activity remains unknown. Here, we observed that BA could protect mice from infection by influenza virus A/PR/8/34 (H1N1), associated with increasing IFN-γ production, but presented no effects in IFN-γ or IFN-γ receptor deficient mice. Further study indicated that BA could inhibit A/PR/8/34 replication through IFN-γ in human PBMC. Moreover, BA can directly induce IFN-γ production in human CD4+ and CD8+ T cells and NK cells, and activate JAK/STAT-1 signaling pathway. Collectively, BA exhibited anti-influenza virus A (H1N1) activity in vitro and in vivo as a potent inducer of IFN-γ in major IFN-γ producing cells.

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Section: Introductionmentioning

confidence: 99%

Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma

Chu

Zhang

et al. 2015

BioMed Research International

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“…Among the 9 KEGG pathways enriched in both the HT vs LT group and the HT vs NT group, 4 KEGG pathways (influenza A, legionellosis, lnflammatory bowel disease (IBD) and measles) were related to immune and infectious diseases, and 4 KEGG pathways (NOD-like receptor signaling pathway, osteoclast differentiation, plant-pathogen interaction inflammatory bowel disease (IBD) and antigen processing and presentation) were related to the immune system. Considering that heat stress has a negative effect on the inner immune system 30 , 31 , it is no wonder that infection-related pathways (e.g., influenza A) and immune system response pathways (e.g., NOD-like receptor signaling pathway) are activated after stress treatments.…”

Section: Discussionmentioning

confidence: 99%

Deep Transcriptomic Analysis of Black Rockfish (Sebastes schlegelii) Provides New Insights on Responses to Acute Temperature Stress

Lyu

Wen

et al. 2018

Sci Rep

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In the present study, we conducted an RNA-Seq analysis to characterize the genes and pathways involved in acute thermal and cold stress responses in the liver of black rockfish, a viviparous teleost that has the ability to cope with a wide range of temperature changes. A total of 584 annotated differentially expressed genes (DEGs) were identified in all three comparisons (HT vs NT, HT vs LT and LT vs NT). Based on an enrichment analysis, DEGs with a potential role in stress accommodation were classified into several categories, including protein folding, metabolism, immune response, signal transduction, molecule transport, membrane, and cell proliferation/apoptosis. Considering that thermal stress has a greater effect than cold stress in black rockfish, 24 shared DEGs in the intersection of the HT vs LT and HT vs NT groups were enriched in 2 oxidation-related gene ontology (GO) terms. Nine important heat-stress-reducing pathways were significantly identified and classified into 3 classes: immune and infectious diseases, organismal immune system and endocrine system. Eight DEGs (early growth response protein 1, bile salt export pump, abcb11, hsp70a, rtp3, 1,25-dihydroxyvitamin d(3) 24-hydroxylase, apoa4, transcription factor jun-b-like and an uncharacterized gene) were observed among all three comparisons, strongly implying their potentially important roles in temperature stress responses.

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“…Since it is well established that endotoxin (lipopolysaccharide, LPS) is strong inducer of the inflammatory cytokines this study left scope for discovering how this occurs. It is probable that either HS caused immune suppression in the animal ( Meng et al, 2013 ) or LPS was not as high as it appeared due to i) a technical error, ii) structural differences ( Trent et al, 2006 ), iii) differential composition ( Im et al, 2015 ; Lam et al, 2011 ) or iv) binding proteins of LPS ( Lam et al, 2011 ; Im et al, 2015 ). It could well be that HS together with LPS does not induce all pro-inflammatory cytokines and perhaps are linked with specific cytokines such as IL-17 and/or transforming growth factor-β (TGF-β) which are in relation with regulatory T (Treg) and Th17 T cells.…”

Section: Gut Immunity In Pigs Under Various Stressorsmentioning

confidence: 99%

Stress, Nutrition, and Intestinal Immune Responses in Pigs — A Review

Lee

Kye

Kim

et al. 2016

Asian Australas. J. Anim. Sci

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Modern livestock production became highly intensive and large scaled to increase production efficiency. This production environment could add stressors affecting the health and growth of animals. Major stressors can include environment (air quality and temperature), nutrition, and infection. These stressors can reduce growth performance and alter immune systems at systemic and local levels including the gastrointestinal tract. Heat stress increases the permeability, oxidative stress, and inflammatory responses in the gut. Nutritional stress from fasting, antinutritional compounds, and toxins induces the leakage and destruction of the tight junction proteins in the gut. Fasting is shown to suppress pro-inflammatory cytokines, whereas deoxynivalenol increases the recruitment of intestinal pro-inflammatory cytokines and the level of lymphocytes in the gut. Pathogenic and viral infections such as Enterotoxigenic E. coli (ETEC) and porcine epidemic diarrhea virus can lead to loosening the intestinal epithelial barrier. On the other hand, supplementation of Lactobacillus or Saccharaomyces reduced infectious stress by ETEC. It was noted that major stressors altered the permeability of intestinal barriers and profiles of genes and proteins of pro-inflammatory cytokines and chemokines in mucosal system in pigs. However, it is not sufficient to fully explain the mechanism of the gut immune system in pigs under stress conditions. Correlation and interaction of gut and systemic immune system under major stressors should be better defined to overcome aforementioned obstacles.

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Chronic Heat Stress Inhibits Immune Responses to H5N1 Vaccination through Regulating CD4⁺CD25⁺Foxp3⁺Tregs

Cited by 21 publications

References 24 publications

Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma

Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma

Deep Transcriptomic Analysis of Black Rockfish (Sebastes schlegelii) Provides New Insights on Responses to Acute Temperature Stress

Stress, Nutrition, and Intestinal Immune Responses in Pigs — A Review

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