Chronic heat treatment positively impacts metabolic profile of ovariectomized rats: association with heat shock response pathways

Lissarassa, Yana Picinin Sandri; Vincensi, Carolain Felipin; Costa-Beber, Lílian Corrêa; Santos, Analú Bender Dos; Goettems-Fiorin, Pauline Brendler; Santos, Jaíne Borges Dos; Donato, Yohanna Hannnah; Wildner, Guilherme; Júnior, Paulo Ivo Homem de Bittencourt; Frizzo, Matias Nunes; Heck, Thiago Gomes; Ludwig, Mirna Stela

doi:10.1007/s12192-020-01087-z

Cited by 15 publications

(6 citation statements)

References 62 publications

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“…Controlled heat disassembles NLRP3 inflammasome, rescues HuR-SIRT1-HSF1 axis and resumes the resolution of inflammation [ 143 , 144 ]. This explains why chronic heat treatment is effective in relieving atherosclerotic lesions and stopping death in mouse models [ 151 ], while improving metabolic status of ovariectomized rats [ 152 ] and obese mice with insulin resistance [ 94 ]. For this reason, it is intriguing to perceive that, after two decades since the seminal report that 30 min sessions of hot-tub therapy (37.8–41.0 °C) for just 3 weeks is able to reduce plasma glucose and HbA 1c levels in diabetic patients [ 153 ], no clinical trial was conducted to outline the whole scenario of the HSR in diabetic patients under hyperthermic therapy.…”

Section: Bypassing Chronic Suppression Of Hsr and Re-arming The Resolmentioning

confidence: 99%

Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies

et al. 2020

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The major risk factors to fatal outcome in COVID-19 patients, i.e., elderliness and pre-existing metabolic and cardiovascular diseases (CVD), share in common the characteristic of being chronic degenerative diseases of inflammatory nature associated with defective heat shock response (HSR). The molecular components of the HSR, the principal metabolic pathway leading to the physiological resolution of inflammation, is an anti-inflammatory biochemical pathway that involves molecular chaperones of the heat shock protein (HSP) family during homeostasis-threatening stressful situations (e.g., thermal, oxidative and metabolic stresses). The entry of SARS coronaviruses in target cells, on the other hand, aggravates the already-jeopardized HSR of this specific group of patients. In addition, cellular counterattack against virus involves interferon (IFN)-mediated inflammatory responses. Therefore, individuals with impaired HSR cannot resolve virus-induced inflammatory burst physiologically, being susceptible to exacerbated forms of inflammation, which leads to a fatal “cytokine storm”. Interestingly, some species of bats that are natural reservoirs of zoonotic viruses, including SARS-CoV-2, possess an IFN-based antiviral inflammatory response perpetually activated but do not show any sign of disease or cytokine storm. This is possible because bats present a constitutive HSR that is by far (hundreds of times) more intense and rapid than that of human, being associated with a high core temperature. Similarly in humans, fever is a physiological inducer of HSR while antipyretics, which block the initial phase of inflammation, impair the resolution phase of inflammation through the HSR. These findings offer a rationale for the reevaluation of patient care and fever reduction in SARS, including COVID-19.

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Section: Bypassing Chronic Suppression Of Hsr and Re-arming The Resolmentioning

confidence: 99%

Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies

et al. 2020

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“…Some studies had confirmed that estrogen plays a positive role in maintaining a low level of TC. And the loss of the protective effect of estrogen will significantly increase the obesity rate and the risk of dyslipidemia in middle-aged and elderly women [12][13][14]. This indicated that more attention should be paid to the lipids level in this group people.…”

Section: Discussionmentioning

confidence: 99%

Associations of environmental factors with total cholesterol level of middle-aged and elderly people in China

Pei

et al. 2022

BMC Public Health

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Background Dyslipidemia is a key factor causing cardio cerebrovascular diseases, and the total cholesterol (TC) is an important lipid indicator among them. Studies have shown that environmental factors have a strong association with TC levels. Previous studies only focused on the seasonal variation of TC level and the short-term effects of some environmental factors on TC level over time, and few studies explored the geographical distribution of TC level and quantified the impact of environmental factors in space. Methods Based on blood test data which was from China Health and Retirement Longitudinal Study (Charls) database, this study selected the TC level test data of middle-aged and elderly people in China in 2011 and 2015, and collected data from 665 meteorological stations and 1496 air pollutant monitoring stations in China. After pretreatment, the spatial distribution map of TC level was prepared and the regional statistics were made. GeoDetector and geographically weighted regression (GWR) were used to measure the relationship between environmental factors and TC level. Results The TC level of middle-aged and elderly in China was higher in females than in males, and higher in urban areas than in rural areas, showing a clustered distribution. The high values were mainly in South China, Southwest China and North China. Temperature, humidity, PM10 and PM2.5 were significant environmental factors affecting TC level of middle-aged and elderly people. The impact of pollutants was more severe in northern China, and TC level in southern China was mainly affected by meteorological factors. Conclusions There were gender and urban-rural differences in TC levels among the middle-aged and elderly population in China, showing aggregation in geographical distribution. Meteorological factors and air pollutants may be very important control factors, and their influencing mechanism needs further study.

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“…HSP72 plays a fundamental role as a chaperone, anti-inflammatory, antioxidant, and antiapoptotic protein [ 38 ], whose expression is regulated by E2 [ 39 , 40 ]. However, previous studies showed that a short and middle deprivation of E2 does not downregulate HSP72 expression [ 41 , 42 ], which suggests that the cellular response to stress during hypoestrogenism may depend on the time of postmenopause [ 43 ]. We found a curvilinear relationship between eHSP72 levels and the time of menopause, with decreasing values during the first 11 years and increasing values between 12 to 29 years of menopause.…”

Section: Discussionmentioning

confidence: 99%

Oxidative and Cellular Stress Markers in Postmenopause Women with Diabetes: The Impact of Years of Menopause

Anklam

Lissarassa

Santos

et al. 2021

Journal of Diabetes Research

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Women live approximately one-third of their lives in postmenopause. Among postmenopausal women, type 2 diabetes mellitus (DM2) is one of the most prevalent chronic diseases. These conditions promote alterations in the oxidative, metabolic, and immune-inflammatory profiles marked by higher extracellular 72 kDa-heat shock protein (eHSP72). Here, we investigated whether the time of menopause is associated with oxidative cellular stress marker levels in postmenopausal women with DM2. Sixty-four women were recruited ( 56.7 ± 12.6 years old) in the pre- ( n = 22 ) and postmenopause ( n = 42 ) period, with ( n = 19 ) or without DM2 ( n = 45 ), and a fasting blood collection was made for the evaluation of metabolic, oxidative, and inflammatory markers. We found that menopause and DM2 influenced metabolic and oxidative parameters and presented synergistic effects on the plasma lipoperoxidation levels. Also, postmenopausal women had the highest eHSP72 concentration levels associated with the years in postmenopause. We conclude that the time of menopause impacts the markers of cellular stress and increases the risk of oxidative stress, mainly when it is associated with DM2.

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Chronic heat treatment positively impacts metabolic profile of ovariectomized rats: association with heat shock response pathways

Cited by 15 publications

References 62 publications

Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies

Suppressed anti-inflammatory heat shock response in high-risk COVID-19 patients: lessons from basic research (inclusive bats), light on conceivable therapies

Associations of environmental factors with total cholesterol level of middle-aged and elderly people in China

Oxidative and Cellular Stress Markers in Postmenopause Women with Diabetes: The Impact of Years of Menopause

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