Chronic Helicobacter cinaedi cellulitis diagnosed by microbial polymerase chain reaction

Matsumoto, Andrew; Yeh, Iwei; Schwartz, Brian S.; Rosenblum, Michael D.; Schmidt, Timothy H.

doi:10.1016/j.jdcr.2017.05.009

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…Nevertheless, the fact that the bacterium has been recorded in different regions of the globe suggests that this pathogen may be widespread. In addition, publications have repeatedly emphasized that H. cinaedi is difficult to detect by standard methods of analysis because the bacterium is characterized by slow growth and requirements for atmospheric composition ( Kawamura et al, 2014 ; Matsumoto et al, 2017 ; Nukui et al, 2020 ). Thus, in some cases, the presence of H. cinaedi in humans may not have been detected due to the specific culturing conditions required for the bacterium.…”

Section: The History Of Research On the Bacterium Helicobac...mentioning

confidence: 99%

Helicobacter cinaedi bacterium association with atherosclerosis and other diseases

Voronina,

Arapidi

2024

Front. Microbiol.

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Helicobacter is a genus of spiral-shaped Gram-negative enterohepatic bacteria whose members are capable of causing bacteremia in humans. One of the poorly studied members of this genus is the bacterium Helicobacter cinaedi. This microorganism was first isolated from human fecal samples in 1984. Although it was long considered to be associated with only immunocompromised patients, more evidence in recent years has implicated H. cinaedi in causing serious pathologies in immunocompetent populations. In addition, H. cinaedi is also reported to be associated with a few chronic or severe illnesses, such as atherosclerosis, which in turn can lead to the development of other cardiovascular pathologies: one of the leading causes of mortality worldwide. Helicobacter cinaedi often goes unnoticed in standard diagnostic methods due to its slow growth under microaerobic conditions. This often leads to significant underdetection and hence undermines the role of this bacterium in the pathogenesis of various diseases and the extent of its spread in humans. In this review, we have compiled information on pathologies associated with H. cinaedi, the occurrence of the bacterium in humans and animals, and the latest developments in diagnosing the bacterium and treating associated diseases.

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Section: The History Of Research On the Bacterium Helicobac...mentioning

confidence: 99%

Helicobacter cinaedi bacterium association with atherosclerosis and other diseases

Voronina,

Arapidi

2024

Front. Microbiol.

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Helicobacter cinaedi-Associated Refractory Cellulitis in Patients with X-Linked Agammaglobulinemia

et al. 2020

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Genome Sequencing Verifies Relapsed Infection of Helicobacter cinaedi

Sawada

Gotoh

Taniguchi

et al. 2019

Open Forum Infectious Diseases

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Background Recurrent infections of Helicobacter cinaedi are often reported, and long-term antimicrobial treatment is empirically recommended to prevent such infections. However, there have been no studies examining whether recurrent infections are relapses of former infections or reinfections with different clones. Methods A 69-year-old woman presented with recurrent H cinaedi bacteremia-associated cellulitis after a 51-day interval. We isolated 10 colonies from the blood cultures obtained during each of the 2 episodes and subjected them to whole-genome sequencing (WGS). High-confidence single-nucleotide polymorphisms (SNPs) were identified by an assembly based method. Heterogeneous SNP sites were identified by read mapping. The susceptibility of a representative isolate to 14 antimicrobials was also examined. Results Whole-genome sequence analysis revealed only 6 SNP sites among the 20 isolates at the whole-genome level. Based on the 6 SNPs, 5 within-host variants (referred to as genotypes) were identified. All 5 genotypes were detected in the first infection; however, only 2 genotypes were detected in the second infection. Although the H cinaedi clone showed a higher minimum inhibitory concentration to fluoroquinolones and macrolides and responsible mutations were identified, none of the 6 SNPs appeared related to additional resistance. Conclusions The second infection analyzed here was a relapse of the first infection. A certain level of within-host genomic heterogeneity of the H cinaedi clone was already present in the first infection. Our results suggest the importance of longer treatment courses to eradicate H cinaedi for preventing the relapse of its infection.

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Chronic Helicobacter cinaedi cellulitis diagnosed by microbial polymerase chain reaction

Cited by 4 publications

References 8 publications

Helicobacter cinaedi bacterium association with atherosclerosis and other diseases

Helicobacter cinaedi bacterium association with atherosclerosis and other diseases

Helicobacter cinaedi-Associated Refractory Cellulitis in Patients with X-Linked Agammaglobulinemia

Genome Sequencing Verifies Relapsed Infection of Helicobacter cinaedi

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