Chronic Hepatitis B Infection

Tang, Lydia; Covert, Emily; Wilson, Eleanor; Kottilil, Shyam

doi:10.1001/jama.2018.3795

Cited by 558 publications

(529 citation statements)

References 104 publications

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“…They are divided into several subtypes including hepatitis A, B, C, D, and E. Hepatitis C virus (HCV) represents half of the hepatitis mortality and it is the chief cause for liver fibrosis, cirrhosis, and cancer . Hepatitis B virus (HBV) also leads to major complications and if left untreated, 15 to 40 % of the cases progress to liver cirrhosis . Acute hepatitis caused by hepatitis A virus (HAV) represents one of the most common causes of foodborne infection …”

Section: Introductionmentioning

confidence: 99%

“…[6] Hepatitis B virus (HBV) also leads to major complications and if left untreated, 15 to 40 % of the cases progress to liver cirrhosis. [8] Acute hepatitis caused by hepatitis A virus (HAV) represents one of the most common causes of foodborne infection. [9] Natural products were and will always be an empirical source of antimicrobial agents.…”

Section: Introductionmentioning

confidence: 99%

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Breaking Down the Barriers to a Natural Antiviral Agent: Antiviral Activity and Molecular Docking of Erythrina speciosa Extract, Fractions, and the Major Compound

Fahmy

Al‐Sayed

Moghannem

et al. 2020

Chemistry & Biodiversity

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The in vitro cytotoxic activity in Vero cells and the antiviral activity of Erythrina speciosa methanol extract, fractions, and isolated vitexin were studied. The results revealed that E. speciosa leaves ethyl acetate soluble fraction of the methanol extract (ESLE) was the most active against herpes simplex virus type 1 (HSV‐1). Bioactivity‐guided fractionation was performed on ESLE to isolate the bioactive compounds responsible for this activity. One sub‐fraction from ESLE (ESLE IV) showed the highest activity against HSV‐1 and Hepatitis A HAV‐H10 viruses. Vitexin isolated from ESLE VI exhibited a significant antiviral activity (EC50=35±2.7 and 18±3.3 μg/mL against HAV‐H10 and HSV‐1 virus, respectively), which was notably greater than the activity of the extract and the fractions. Molecular docking studies were carried out to explore the molecular interactions of vitexin with different macromolecular targets. Analysis of the in silico data together with the in vitro studies validated the antiviral activity associated with vitexin. These outcomes indicated that vitexin is a potential candidate to be utilized commendably in lead optimization for the development of antiviral agents.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Breaking Down the Barriers to a Natural Antiviral Agent: Antiviral Activity and Molecular Docking of Erythrina speciosa Extract, Fractions, and the Major Compound

Fahmy

Al‐Sayed

Moghannem

et al. 2020

Chemistry & Biodiversity

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“…The prevalence of CHB infection is high in China, with approximately 90 million people living with CHB, (Yu, Wang, Zhu, Leng, & Wangen, ). CHB infection increases the risk of developing severe liver diseases, such as cirrhosis, hepatic decompensation and hepatocellular carcinoma (Tang, Covert, Wilson, & Kottilil, ). Approximately 300,000 people die from CHB‐related diseases every year in China (Leng et al, ).…”

Section: Introductionmentioning

confidence: 99%

Factors for self‐management activities among rural patients with chronic hepatitis B: A cross‐sectional study

Kong

et al. 2019

Journal of Clinical Nursing

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Aims and objectives To assess the self‐management activities among rural patients with chronic hepatitis B (CHB), and the influence of psychosocial and demographic factors on their self‐management activities. Background Chronic hepatitis B is a serious public health concern. Rural patients may have limited access to healthcare services. Although self‐management is important for controlling chronic hepatitis B, few studies focus on the self‐management activities among rural patients with chronic hepatitis B. Understanding self‐management activities and related factors in this population are important to design and implement appropriate intervention strategies. Design A cross‐sectional study. Methods From June–December 2017, totally 236 rural patients with chronic hepatitis B were recruited from hepatology department in two hospitals in Chongqing, China. The questionnaire included demographic characteristics, Chronic Hepatitis B Self‐Management Scale, Self‐Efficacy for Managing Chronic Disease, and Social Support Rating Scale. The study followed the STROBE checklist. Results Rural patients with chronic hepatitis B reported poor self‐management activities for the score indexes of symptom management (57.36%), lifestyle management (54.89%), psychosocial coping (54.84%) and disease information management (53.11%) were all below 60%. Self‐efficacy, objective support, subjective support, gender, education level and marital status showed significant effect on self‐management activities. Conclusion Rural patients with chronic hepatitis B were found to perform insufficient self‐management activities. Self‐efficacy, social support, gender, education level and marital status were identified to influence their self‐management activities. Relevance to clinical practice Self‐management activities should be promoted among rural patients with chronic hepatitis B. The factors that were identified in this study should be addressed when developing interventions to promote the performance of self‐management activities for rural patients with chronic hepatitis B.

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“…With an estimated 240 million chronically infected people worldwide, hepatitis B virus (HBV) infection is a global public health problem (1). HBV infection causes acute and chronic hepatitis and is associated with an elevated risk of developing liver cirrhosis and hepatocellular carcinoma (2).…”

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confidence: 99%

Synaptosomal‐associated protein 29 is required for the autophagic degradation of hepatitis B virus

Lin

Wang

et al. 2019

The FASEB Journal

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Hepatitis B virus (HBV) replication and envelopment is dependent on cellular autophagy. Previously, we have provided evidence for the extensive lysosomal degradation of HBV virions and the hepatitis B surface antigen (HBsAg), which is likely controlled by autophagosome‐lysosome fusion. Synaptosomal‐associated protein 29 (SNAP29) has been identified as a protein specifically mediating autophagosome‐lysosome fusion. Thus, in the present study, we addressed the hypothesis that SNAP29 is required for the autophagic degradation of HBV virions and HBsAg. We found that silencing SNAP29 significantly increased the number of autophagosomes and concomitantly promoted HBV replication and HBsAg production. Conversely, SNAP29 overexpression decreased HBV production. Consistent with this, SNAP29 modulated HBV production by interacting with vesicle‐associated membrane protein 8 (VAMP8) and synergistically regulated HBV replication with Rab7 complexes. Moreover, the production and release of the small HBsAg is strongly regulated by SNAP29 expression, suggesting that its export occurs partly through the autophagic pathway. Our findings provide new evidence, strongly suggesting that autophagic degradation critically determines the production of HBV virions and HBsAg and that this is controlled by the SNAP29‐VAMP8 interaction.—Lin, Y., Wu, C., Wang, X., Liu, S., Kemper, T., Li, F., Squire, A., Zhu, Y., Zhang, J., Chen, X., Lu, M. Synaptosomal‐associated protein 29 is required for the autophagic degradation of hepatitis B virus. FASEB J. 33, 6023–6034 (2019). http://www.fasebj.org

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Chronic Hepatitis B Infection

Cited by 558 publications

References 104 publications

Breaking Down the Barriers to a Natural Antiviral Agent: Antiviral Activity and Molecular Docking of Erythrina speciosa Extract, Fractions, and the Major Compound

Breaking Down the Barriers to a Natural Antiviral Agent: Antiviral Activity and Molecular Docking of Erythrina speciosa Extract, Fractions, and the Major Compound

Factors for self‐management activities among rural patients with chronic hepatitis B: A cross‐sectional study

Synaptosomal‐associated protein 29 is required for the autophagic degradation of hepatitis B virus

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