Chronic Hepatitis C Virus Infection is Associated with an Increased Risk of Lung Cancer: A Systematic Review and Meta-analysis

Ponvilawan, Ben; Charoenngam, Nipith; Rujirachun, Pongprueth; Wattanachayakul, Phuuwadith; Tornsatitkul, Surapa; Rittiphairoj, Thanitsara; Ungprasert, Patompong

doi:10.1007/s00408-020-00365-y

Cited by 14 publications

(13 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The limitations of this review, due to the paucity of publications, are twofold: the unclear association between specific biological pollutants and lung cancer, and the mechanisms that have not been fully elucidated. In the case of viruses, HCV has been reported to play a role in lung tumorigenesis [ 99 , 100 ]. Some studies have suggested that HCV could inhibit cancer cell apoptosis by interfering with the p53 signaling pathway and downregulating pro-apoptotic proteins, such as caspase-3 and TNF-α [ 101 , 102 ].…”

Section: Discussionmentioning

confidence: 99%

Dark under the Lamp: Neglected Biological Pollutants in the Environment Are Closely Linked to Lung Cancer

Wang,

Chan,

Zhang

et al. 2024

IJMS

View full text Add to dashboard Cite

Environmental pollutants are closely linked to lung cancer. The different types of environmental pollutants can be classified as chemical, physical, and biological. The roles of common chemical and physical pollutants such as PM2.5, smoking, radon, asbestos, and formaldehyde in lung cancer have been extensively studied. Notably, the worldwide COVID-19 pandemic raised awareness of the strong link between biological pollution and human health. Allergens such as house dust mites and pollen, as well as bacteria and viruses, are common biological pollutants. A few biological pollutants have been reported to promote lung cancer via inducing inflammatory cytokines secretion, such as IL-1β, IL-6, and TGF-β, as well as suppressing immunosurveillance by upregulating regulatory T (Treg) cells while dampening the function of CD8+ T cells and dendritic cells. However, the correlation between common biological hazards, such as SARS-CoV-2, human immunodeficiency viruses, Helicobacter pylori, and house dust mites, and lung cancer is not fully elucidated, and the underlying mechanisms are still unclear. Moreover, the majority of studies that have been performed in lung cancer and biological carcinogens were not based on the perspective of biological pollutants, which has challenged the systematicity and coherence in the field of biological pollutants in lung cancer. Here, in addition to reviewing the recent progress made in investigating the roles of allergens, viruses, and bacteria in lung cancer, we summarized the potential mechanisms underlying biological pollutants in lung cancer. Our narrative review can shed light on understanding the significance of biological pollutants in lung cancer, as well as inspire and broaden research ideas on lung cancer etiology.

show abstract

Section: Discussionmentioning

confidence: 99%

Dark under the Lamp: Neglected Biological Pollutants in the Environment Are Closely Linked to Lung Cancer

Wang,

Chan,

Zhang

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Hepatitis B virus (HBV) infection is a critical public health problem globally; nearly 30% of the global population demonstrates serological evidence of current or past HBV infection and that 257,000,000 individuals currently live with chronic HBV infection [ 1 ]. In recent years, aside from hepatocellular carcinoma (HCC), HBV infection has been reported to be associated with the development and progression of various extrahepatic tumors, such as lung cancer [ 2 ], lymphoma [ 3 ], esophageal cancer [ 4 ], colorectal cancer [ 5 ], and gastric cancer (GC) [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Predictive value of hepatitis B serological indicators for mortality among cancer survivors and validation in a gastric cancer cohort

Zhang,

Qu,

Pan

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Hepatitis B virus (HBV) infection has gradually been considered to associate with cancer development and progression. This study aimed to explore the associations of serological indicators of HBV infection with mortality risk among cancer survivors and further validated using a gastric cancer (GC) cohort from China, where HBV infection is endemic. National Center for Health Statistics’ National Health and Nutrition Examination Survey (NHANES) data were used in this study. Individuals with positive results of hepatitis B core antigen (anti-HBc) were considered to have current or past HBV infection. Serological indicators were positive only for hepatitis B surface antibodies (anti-HBs), indicating vaccine-induced immunity, whereas negativity for all serologic indicators was considered to indicate the absence of HBV infection and immunity to HBV. The GC cohort included patients from the First Hospital of Jilin University, China. The median follow-up time of the NHANES was 10 years; during the follow-up, 1505 deaths occurred. The results revealed that anti-HBs-positive cancer survivors had a 39% reduced risk of mortality (hazard ratio [HR] 0.61, 95% confidence interval [CI] 0.44–0.85). Men and individuals aged <65 years old with past exposure to HBV had higher mortality risk (HR 1.52, 95% CI 1.09–2.13; HR 2.07, 95% CI 1.13–3.83). In this GC cohort, individuals who were only anti-HBs-positive showed a reduced risk of mortality (HR 0.77, 95% CI 0.62–0.95). Thus, anti-HBs positivity was a significant factor of decreased mortality among cancer survivors. More rigorous surveillance is necessary for cancer survivors with anti-HBc positivity, particularly men, and younger individuals.

show abstract

“…In addition to hepatocellular carcinoma, both chronic hepatitis B virus (HBV) and chronic hepatitis C virus (HCV) infection have gradually been recognized to associate with the development and progression of multiple extrahepatic malignancies, including colorectal cancer ( 5 ), lung cancer ( 6 ), esophageal cancer ( 7 ), and lymphoma ( 8 ). In recent years, the potential association between chronic hepatitis and GC development has been postulated and achieved special attention.…”

Section: Introductionmentioning

confidence: 99%

Chronic Hepatitis Virus Infection Are Associated With High Risk of Gastric Cancer: A Systematic Review and Cumulative Analysis

Yang

Jiang

Wu³

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

Mounting studies demonstrated both chronic hepatitis B virus (HBV) and chronic hepatitis C virus (HCV) infection might be associated not only with an increased risk of hepatocellular carcinoma but also extrahepatic malignancies, i.e., gastric cancer (GC). However, a quantitative result addressing the association between HBV/HCV infection and GC development is scarce. A systematic search to identify the eligible studies was performed in four databases, including MEDLINE, EMBASE, Cochrane Library, and the PsychINFO. The relationship between HBV/HCV infection and the risk of GC was quantified by calculating the hazard ratio (HR) with a 95% confidence interval (CI). More methodologies of this study were available in the PROSPERO (ID: CRD42021243719). Thirteen included studies involving 7,027,546 individuals (mean age, 42.6-71.9 years) were enrolled in the pooled analyses. Two articles provided the clinical data of both HBV and HCV infections. The proportion of high methodological quality studies was 76.9% (10/13). Synthetic results from 10 eligible studies of HBV showed that HBV infection was associated with a significantly higher risk of GC when compared with the healthy controls without HBV infection (pooled HR, 1.26; 95% CI, 1.08–1.47; P = 0.003; heterogeneity, I2 = 89.3%; P< 0.001). In line with this finding, the combined effect derived from five included studies of HCV also supported a significant positive association between chronic HBV infection and GC development (pooled HR, 1.88; 95% CI, 1.28–2.76; P = 0.001; heterogeneity, I2 = 74.7%; P = 0.003). In conclusion, both chronic HBV and HCV infections were related to a high risk of GC. The plausible mechanisms underlying such association might be correlated to HBV/HCV infection-induced persistent inflammation, immune dysfunction, and cirrhosis.Systematic Review RegistrationPROSPERO (http://www.crd.york.ac.uk/PROSPERO), identifier (CRD42021243719).

show abstract

Chronic Hepatitis C Virus Infection is Associated with an Increased Risk of Lung Cancer: A Systematic Review and Meta-analysis

Cited by 14 publications

References 47 publications

Dark under the Lamp: Neglected Biological Pollutants in the Environment Are Closely Linked to Lung Cancer

Dark under the Lamp: Neglected Biological Pollutants in the Environment Are Closely Linked to Lung Cancer

Predictive value of hepatitis B serological indicators for mortality among cancer survivors and validation in a gastric cancer cohort

Chronic Hepatitis Virus Infection Are Associated With High Risk of Gastric Cancer: A Systematic Review and Cumulative Analysis

Contact Info

Product

Resources

About