Chronic Hepatitis Is Common and Often Untreated Among Children with Hepatitis B Infection in the United States and Canada

Ling, Simon C.; Lin, Hsing-Hua; Murray, Karen F.; Rosenthal, Philip; Mogul, Douglas; Rodriguez‐Baez, Norberto; Schwarzenberg, Sarah Jane; Teckman, Jeffrey; Schwarz, Kathleen B.; Li, Hongxia; Anders, Robert A.; Imteyaz, Hejab; Lee, Peter; Oshima, Kiyoko; Kafka, Kim; Islam, N; Riggs, Shannon M.; Nagy, Rosemary A.; Cerkoski, Jacki; Hau, Athena; Cui, Daniel; Rodgers-Augustyniak, Laurie A.; Montanye, Shirley; Feier, Natasha A.; Feier, Joel; Langlois, Camille; Cooper, Kara; Hoofnagle, Jay H.; Sherker, Averell H.; Doo, Edward; Torrance, Rebecca; Hall, Sherry; Averbach, Frani; Haller, Tamara; Hardison, Regina M.; Kelley, Stephanie S.; Lalama, Christina M.; Lawlor, Sharon; Lombardero, M.; Pelesko, Andrew; Stoliker, Donna; Weiner, Melissa; Zadorozny, Ella; Zhao, Qian

doi:10.1016/j.jpeds.2021.05.035

Cited by 15 publications

(17 citation statements)

References 31 publications

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“…Clinical events among the cohort with HBeAg‐negative CHB were infrequent, as previously highlighted in the outcomes among all adult HBRN participants and in the pediatric cohort. [ 17,26 ] ALT flares defined by ALT values greater than 10 times normal occurred in 44 patients at a median of 52 weeks of follow‐up, for a rate of 0.8% per year, a rate lower than reported in the entire HBRN cohort (incidence = 1.51 per 100 PY) but reflective of differences in ALT flare rates between HBeAg‐positive versus HBeAg‐negative CHB. Treatment initiation occurred at a rate of 5.9% in this cohort and was associated with a lower rate of HBsAg loss compared with those who remained untreated.…”

Section: Discussionmentioning

confidence: 95%

Incidence and prediction of HBsAg seroclearance in a prospective multi‐ethnic HBeAg‐negative chronic hepatitis B cohort

Terrault¹,

Wahed²,

Feld³

et al. 2022

Hepatology

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Background and Aims: Achieving HBsAg loss is an important landmark in the natural history of chronic hepatitis B (CHB). A more personalized approach to prediction of HBsAg loss is relevant in counseling patients. This study sought to develop and validate a prediction model for HBsAg loss based on quantitative HBsAg levels (qHBsAg) and other baseline characteristics.Methods: The Hepatitis B Research Network (HBRN) is a prospective cohort including 1240 untreated HBeAg-negative patients (1150 adults, 90 children) with median follow-up of 5.5 years. Incidence rates of HBsAg loss and hepatitis B surface antibody (anti-HBs) acquisition were determined, and a predictor

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Section: Discussionmentioning

confidence: 95%

Incidence and prediction of HBsAg seroclearance in a prospective multi‐ethnic HBeAg‐negative chronic hepatitis B cohort

Terrault¹,

Wahed²,

Feld³

et al. 2022

Hepatology

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“…Como mencionan (Guerrero & Acevedo, 2021) que es importante conocer el efecto de la contaminación en la calidad y salubridad de los productos de consumo humano. Así mismo, en Estados Unidos y Canadá (Ling et al, 2021) debe a la falta de un sistema de gestión de residuos sólidos para la actividad turística.…”

Section: Discussionunclassified

Contaminación por Residuos Sólidos Urbanos: Caso Comunidad de Occochaca, Huanta, Perú, 2021

Marchan-Solier¹,

Zorrilla-Crespo²,

Cardenas-Quispe³

et al. 2021

SRJCIDI

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La contaminación por residuos sólidos urbanos es un problema que afecta a todas las ciudades sobre todo en las zonas rurales de la región de Ayacucho. Por consiguiente, se tuvo como objetivo determinar el nivel de contaminación por residuos sólidos urbanos en la comunidad de Occochaca. La investigación se desarrolló con un enfoque cuantitativo, de tipo descriptivo, diseño no experimental, nivel correlacional causal y de corte transversal. La muestra estuvo conformada por 30 pobladores de 18 a 65 años de la comunidad de Occochaca, mediante un muestreo no probabilístico intencional. Se utilizo un cuestionario como técnica de recolección de datos. Los resultados indicaron que existe una mala gestión de residuos sólidos urbanos en la actividad turística en Occochaca que afecto directamente a la siembra de palta, además el 34% de pobladores tuvo hepatitis B y el 30% sufrió de anemia. Se concluye que los residuos sólidos urbanos como latas, pilas y equipos electrónicos son los principales contaminantes de la zona.

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“…However, a recent study from the USA/Canada Hepatitis B Research Network of hepatitis B in children found that almost all (98%) had acquired HBV through vertical transmission, including 26% of pediatric cases who were born in the USA or Canada. [ 5] Indeed, in some Canadian judications, health policy advisors continue to argue that in a low‐HBV‐endemic region, prenatal screening programs and related interventions can effectively prevent vertical transmission without need for a universal infant vaccination program. This policy is refuted based on results from a recent descriptive study using administrative lab data in Ontario, Canada, which identified inadequate prenatal HBV screening and/or gaps in maternal HBV care and diagnosis of pediatric HBV infection in Canadian‐born children, even before they were actually eligible for the adolescent HBV vaccine program.…”

Section: The Importance Of Universal Birth‐dose Vaccination In the Fi...mentioning

confidence: 99%

The remarkable success of the vaccine for a killer virus: Hepatitis B

Coffin

2022

Hepatology

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Chronic Hepatitis Is Common and Often Untreated Among Children with Hepatitis B Infection in the United States and Canada

Cited by 15 publications

References 31 publications

Incidence and prediction of HBsAg seroclearance in a prospective multi‐ethnic HBeAg‐negative chronic hepatitis B cohort

Incidence and prediction of HBsAg seroclearance in a prospective multi‐ethnic HBeAg‐negative chronic hepatitis B cohort

Contaminación por Residuos Sólidos Urbanos: Caso Comunidad de Occochaca, Huanta, Perú, 2021

The remarkable success of the vaccine for a killer virus: Hepatitis B

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