Chronic high fat diet consumption impairs sensorimotor gating in mice

Labouesse, Marie A.; Stadlbauer, Ulrike; Langhans, Wolfgang; Meyer, Urs

doi:10.1016/j.psyneuen.2013.06.003

Cited by 36 publications

(34 citation statements)

References 51 publications

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“…2). Our data confirmed previous findings that 8 weeks of HFD from a young age (4 weeks old) induced PPI disruption of acoustic startle (Labouesse et al 2013) (Fig. 3a).…”

Section: Discussionsupporting

confidence: 93%

“…These results suggest that the obesity phenotype may be related to schizophrenia-like behavioral abnormalities. However, to our knowledge, HFD-induced PPI disruption (Labouesse et al 2013) has not yet been replicated. Moreover, it is unclear whether the impairment is long-lasting or not.…”

Section: Introductionmentioning

confidence: 83%

“…A recent study reported that expression of tyrosine hydroxylase density in the nucleus accumbens shell was negatively correlated with mean PPI scores and that haloperidol, a typical antipsychotic and D 2 R antagonist, mitigated PPI disruption induced by HFD (Labouesse et al 2013). D 1 R may also play an important role in the disruption of PPI.…”

Section: Introductionmentioning

confidence: 98%

“…HFD also induced cognitive impairments in rats (Pathan et al 2008). Interestingly, a recent study showed that long-term HFD-induced disruption of prepulse inhibition (PPI) in mice (Labouesse et al 2013). Reduced PPI of acoustic startle has been associated with schizophrenia (Braff et al 1978).…”

Section: Introductionmentioning

confidence: 99%

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Possible role of the dopamine D1 receptor in the sensorimotor gating deficits induced by high-fat diet

et al. 2015

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“…2). Our data confirmed previous findings that 8 weeks of HFD from a young age (4 weeks old) induced PPI disruption of acoustic startle (Labouesse et al 2013) (Fig. 3a).…”

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Possible role of the dopamine D1 receptor in the sensorimotor gating deficits induced by high-fat diet

et al. 2015

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“…The stimulus--onset asynchrony of the prepulse and pulse stimuli on all prepulse--plus--pulse trials was 100 ms (onset--to--onset). The protocol used for the PPI test was extensively validated in our laboratory before (e.g., Labouesse et al 2013, Vuillermot et al 2010. A session began with the animals being placed into the Plexiglas enclosure.…”

Section: Animalsmentioning

confidence: 99%

Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice

2015

Self Cite

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Rationale. Multiple lines of evidence suggest that the sex steroid hormone 17--β estradiol (E2) plays a protective role in schizophrenia. Systemic E2 enhances prepulse inhibition (PPI) of the acoustic startle reflex, an operational measure of sensorimotor gating known to be impaired in schizophrenia and related disorders. However, the relative contribution of different estrogen--receptor (ER) isoforms in these associations still awaits examination. Results. Acute pharmacological stimulation and blockade of ER--α, respectively, led to a dose--dependent increase and decrease in basal PPI. In contrast, acute treatment with preferential ER--β modulators spared PPI under basal conditions. Pretreatment with either ER--α or ER--β agonist was, however, effective in blocking amphetamine--induced PPI disruption. Conclusions.Our study demonstrates that activation of either ER isoform is capable of modulating dopamine--dependent PPI levels. At the same time, our results suggest that endogenous ER--α signaling may be more relevant than ER--β in the regulation of sensorimotor gating under basal conditions.

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The impact of junk foods on the adolescent brain

Reichelt

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2017

Birth Defects Research

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Adolescence is a significant period of physical, social, and emotional development, and is characterized by prominent neurobiological changes in the brain. The maturational processes that occur in brain regions responsible for cognitive control and reward seeking may underpin excessive consumption of palatable high fat and high sugar "junk" foods during adolescence. Recent studies have highlighted the negative impact of these foods on brain function, resulting in cognitive impairments and altered reward processing. The increased neuroplasticity during adolescence may render the brain vulnerable to the negative effects of these foods on cognition and behavior. In this review, we describe the mechanisms by which junk food diets influence neurodevelopment during adolescence. Diet can lead to alterations in dopamine-mediated reward signaling, and inhibitory neurotransmission controlled by γ-aminobutyric acid (GABA), two major neurotransmitter systems that are under construction across adolescence. We propose that poor dietary choices may derail the normal adolescent maturation process and influence neurodevelopmental trajectories, which can predispose individuals to dysregulated eating and impulsive behaviors.

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Chronic high fat diet consumption impairs sensorimotor gating in mice

Cited by 36 publications

References 51 publications

Possible role of the dopamine D1 receptor in the sensorimotor gating deficits induced by high-fat diet

Possible role of the dopamine D1 receptor in the sensorimotor gating deficits induced by high-fat diet

Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice

The impact of junk foods on the adolescent brain

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