Chronic High-Fat Diets Induce Oxide Injuries and Fibrogenesis of Pancreatic Cells in Rats

Zhang, Xiaoli; Cui, Ye-Qing; Li, Fang; Li, Fēi

doi:10.1097/mpa.0b013e3181744b50

Cited by 71 publications

(64 citation statements)

References 23 publications

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“…37 In addition, obesity and pancreatic steatosis have been shown to result in increased cytokine production and fibrosis in the pancreas in studies in which mice were fed a high fat diet. 50, 51 …”

Section: Discussionmentioning

confidence: 99%

Association between novel MRI‐estimated pancreatic fat and liver histology‐determined steatosis and fibrosis in non‐alcoholic fatty liver disease

Patel

Peterson

Brenner

et al. 2013

Aliment Pharmacol Ther

113

112

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SUMMARY Background Ectopic fat deposition in the pancreas and its association with hepatic steatosis have not previously been examined in patients with biopsy-proven non-alcoholic fatty liver disease (NAFLD). Aim To quantify pancreatic fat using a novel magnetic resonance imaging (MRI) technique and determine whether it is associated with hepatic steatosis and/or fibrosis in patients with NAFLD. Methods This is a cross-sectional study including 43 adult patients with biopsy-proven NAFLD who underwent clinical evaluation, biochemical testing and MRI. The liver biopsy assessment was performed using the NASH-CRN histological scoring system, and liver and pancreas fat quantification was performed using a novel, validated MRI biomarker; the proton density fat fraction. Results The average MRI-determined pancreatic fat in patients with NAFLD was 8.5% and did not vary significantly between head, body, and tail of the pancreas. MRI-determined pancreatic fat content increased significantly with increasing histology-determined hepatic steatosis grade; 4.6% in grade 1; 7.7% in grade 2; 13.0% in grade 3 (P = 0.004) respectively. Pancreatic fat content was lower in patients with histology-determined liver fibrosis than in those without fibrosis (11.2% in stage 0 fibrosis vs. 5.8% in stage 1–2 fibrosis, and 6.9% in stage 3–4 fibrosis, P = 0.013). Pancreatic fat did not correlate with age, body mass index or diabetes status. Conclusions In patients with NAFLD, increased pancreatic fat is associated with hepatic steatosis. However, liver fibrosis is inversely associated with pancreatic fat content. Further studies are needed to determine underlying mechanisms to understand if pancreatic steatosis affects progression of NAFLD.

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Section: Discussionmentioning

confidence: 99%

Association between novel MRI‐estimated pancreatic fat and liver histology‐determined steatosis and fibrosis in non‐alcoholic fatty liver disease

Patel

Peterson

Brenner

et al. 2013

Aliment Pharmacol Ther

113

112

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“…Tissue injury and enzyme release in group 3 rats might be due to the elevated level of free radicals formed in EtOH and HFD control rats. Zhang et al [32] reported that HFD feeding increases lipid peroxidation that causes pancreatic injury in rats. The results showed that TQ coadministration reduced the level of lipid peroxidation products in the pancreas, which might have resulted in rescued cell damage.…”

Section: Discussionmentioning

confidence: 99%

Thymoquinone ameliorates NLRP3-mediated inflammation in the pancreas of albino Wistar rats fed ethanol and high-fat diet

Suguna

Geetha

Aruna

et al. 2015

Journal of Basic and Clinical Physiology and Pharmacology

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“…According to animal studies, excessive pancreatic fat infiltration with enhanced production of proinflammatory cytokines and accumulation of free fatty acids induced apoptosis of pancreatic β cells in Zucker diabetic and obese rats and mice 15 16. Chronic exposure to a high-fat diet in rats induced interlobular or intralobular fat accumulation within the pancreas, along with inflammation and fibrosis damaging the cellular architecture of the islets 17. Data from human studies demonstrate that high body mass index (BMI), insulin resistance, metabolic syndrome and liver steatosis are all associated with an increased pancreatic fat content 18–20.…”

Section: Nafpd and Metabolic Riskmentioning

confidence: 99%

Non-alcoholic fatty pancreas disease

Alempijević

Dragašević²,

Zec

et al. 2017

Postgraduate Medical Journal

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Obesity is a growing problem worldwide and disorders associated with excess body fat including the metabolic syndrome, type 2 diabetes mellitus (T2DM), cardiovascular disease and malignant neoplasms are becoming a major cause of morbidity and mortality. Over the past decade, a vast amount of research has furthered our understanding of non-alcoholic fatty liver disease; however, only recently pancreatic fat infiltration is coming to the forefront of investigation. Termed non-alcoholic fatty pancreas disease (NAFPD), it is becoming evident that it has important associations with other diseases of obesity. It appears to arise as obesity progresses and after an initial phase of pancreatic hypertrophy and hyperplasia, fatty infiltration becomes apparent. Various studies have demonstrated that NAFPD may exacerbate the severity of acute pancreatitis, promote pancreatic dysfunction associated with insulin resistance and T2DM, and even have links to the development of pancreatic carcinoma, and therefore, it must be investigated in further detail.

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Chronic High-Fat Diets Induce Oxide Injuries and Fibrogenesis of Pancreatic Cells in Rats

Abstract: The results indicate that chronic HFD increased pancreatic FFA and lipid peroxidation associated with pancreatic injuries and collagen synthesis by activated pancreatic stellate cells in rats.

Cited by 71 publications

References 23 publications

Association between novel MRI‐estimated pancreatic fat and liver histology‐determined steatosis and fibrosis in non‐alcoholic fatty liver disease

Association between novel MRI‐estimated pancreatic fat and liver histology‐determined steatosis and fibrosis in non‐alcoholic fatty liver disease

Thymoquinone ameliorates NLRP3-mediated inflammation in the pancreas of albino Wistar rats fed ethanol and high-fat diet

Non-alcoholic fatty pancreas disease

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