Chronic hypercapnic respiratory failure and non-invasive ventilation in people with chronic obstructive pulmonary disease

Hatipoğlu, Umur; Aboussouan, Loutfi S.

doi:10.1136/bmjmed-2022-000146

Cited by 6 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Non-invasive mechanical ventilation (NIV) is currently used as a long-term home therapy (LTH-NIV) for patients with chronic stable hypercapnic COPD: after the first AHRF episode, long-term NIV can be used for patients with COPD following a life-threatening AHRF episode requiring acute NIV, if hypercapnia persists following this episode [86][87][88].…”

Section: Role Of Non-invasive Ventilation In Preventing Aecopd and Ic...mentioning

confidence: 99%

COPD Exacerbation: Why It Is Important to Avoid ICU Admission

Prediletto

Giancotti

Nava

2023

JCM

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is one of the major causes of morbidity and mortality worldwide. Hospitalization due to acute exacerbations of COPD (AECOPD) is a relevant health problem both for its impact on disease outcomes and on health system resources. Severe AECOPD causing acute respiratory failure (ARF) often requires admission to an intensive care unit (ICU) with endotracheal intubation and invasive mechanical ventilation. AECOPD also acts as comorbidity in critically ill patients; this condition is associated with poorer prognoses. The prevalence reported in the literature on ICU admission rates ranges from 2 to 19% for AECOPD requiring hospitalization, with an in-hospital mortality rate of 20–40% and a re-hospitalization rate for a new severe event being 18% of the AECOPD cases admitted to ICUs. The prevalence of AECOPD in ICUs is not properly known due to an underestimation of COPD diagnoses and COPD misclassifications in administrative data. Non-invasive ventilation in acute and chronic respiratory failure may prevent AECOPD, reducing ICU admissions and disease mortality, especially when associated with a life-threating episode of hypercapnic ARF. In this review, we report on up to date evidence from the literature, showing how improving the knowledge and management of AECOPD is still a current research issue and clinical need.

show abstract

Section: Role Of Non-invasive Ventilation In Preventing Aecopd and Ic...mentioning

confidence: 99%

COPD Exacerbation: Why It Is Important to Avoid ICU Admission

Prediletto

Giancotti

Nava

2023

JCM

View full text Add to dashboard Cite

show abstract

“…Researchers estimate that 1 in 160, or about 2 million people, living in the United States alone have obesity hypoventilation syndrome with an awake Pa co 2 greater than 45 mmHg, 11 and that more than 250,000 people in the United States have severe chronic obstructive pulmonary disease and hypercapnia with Pa co 2 greater than 50 mmHg. 12 In the mirror image of chronic respiratory alkalosis, although very few spend more than a day in the extreme altitude “death zone” above 8,000 m (26,250 feet), 13 more than 80 million people worldwide live in what is a physiologically habitable high-altitude zone between 2,500 and 5,500 m (6,000 to 18,000 feet). 14 However, the largest group of people with chronic respiratory alkalosis likely to receive anesthesia care are women during pregnancy who typically have a Pa co 2 of about 31 mmHg and base-excess of -3.3 mM in the third trimester.…”

mentioning

confidence: 99%